STRINGSTRING
TLR5 TLR5 TLR4 TLR4 JAK1 JAK1 SOCS3 SOCS3 IFNAR1 IFNAR1 TLR-15 TLR-15 TLR3 TLR3 POFUT1 POFUT1 KIF3B KIF3B TLR7 TLR7 XKR7 XKR7 MAVS MAVS IFNG IFNG SOCS1 SOCS1 JUN JUN DUSP8 DUSP8 PKP3 PKP3 RNASEL RNASEL JAK2 JAK2 IL6 IL6 ATF2 ATF2 DDX41 DDX41 IL10 IL10 IFITM5 IFITM5 STAT1 STAT1 PNPLA2 PNPLA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (878 aa)
TLR4Toll like receptor 4. (843 aa)
JAK1Tyrosine-protein kinase. (1152 aa)
SOCS3Suppressor of cytokine signaling 3. (209 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (584 aa)
TLR-15TIR domain-containing protein. (863 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
POFUT1Protein O-fucosyltransferase 1. (386 aa)
KIF3BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (739 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
XKR7XK-related protein. (501 aa)
MAVSCARD_2 domain-containing protein. (619 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit. (276 aa)
DUSP8Dual specificity phosphatase 8. (664 aa)
PKP3Plakophilin 3. (725 aa)
RNASELUncharacterized protein. (772 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
IL6Uncharacterized protein. (350 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (487 aa)
DDX41DEAD-box helicase 41. (437 aa)
IL10Interleukin 10. (177 aa)
IFITM5Interferon induced transmembrane protein 5. (134 aa)
STAT1Signal transducer and activator of transcription. (869 aa)
PNPLA2Patatin like phospholipase domain containing 2. (479 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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