STRINGSTRING
TRAF3 TRAF3 CHRM2 CHRM2 RNASEL RNASEL CALR CALR CHRM5 CHRM5 SOCS1 SOCS1 CHRM4 CHRM4 TRIM8 TRIM8 RO60 RO60 C1S C1S C1R C1R IL-2 IL-2 STAT3 STAT3 TLR3 TLR3 PPARG PPARG TRIM23 TRIM23 IRF8 IRF8 TYRO3 TYRO3 CALR3 CALR3 IFIH1 IFIH1 TGFB2 TGFB2 SOCS3 SOCS3 TLR4 TLR4 IFNG IFNG INS INS STAT1 STAT1 GAS6 GAS6 RXFP1 RXFP1 SAMHD1 SAMHD1 DDX58 DDX58 PTEN PTEN CD40 CD40 CD4 CD4 CD93 CD93 TRIM25 TRIM25 CHRM3 CHRM3 BCL2 BCL2 IL6 IL6 VAV2 VAV2 CD59 CD59 MSN MSN VAV3 VAV3 IRF7 IRF7 IL-17 IL-17 TRAF6 TRAF6 ENSAPLP00000028410 ENSAPLP00000028410 MERTK MERTK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (143 aa)
RNASELUncharacterized protein. (772 aa)
CALRCalreticulin. (531 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (528 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (490 aa)
TRIM8Tripartite motif containing 8. (360 aa)
RO60Ro60, Y RNA binding protein. (538 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (690 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (827 aa)
IL-2Interleukin; Belongs to the IL-15/IL-21 family. (140 aa)
STAT3Signal transducer and activator of transcription. (942 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (450 aa)
TRIM23Tripartite motif containing 23. (582 aa)
IRF8IRF-3 domain-containing protein. (306 aa)
TYRO3TYRO3 protein tyrosine kinase. (960 aa)
CALR3Calreticulin. (389 aa)
IFIH1Interferon induced with helicase C domain 1. (1003 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SOCS3Suppressor of cytokine signaling 3. (209 aa)
TLR4Toll like receptor 4. (843 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
STAT1Signal transducer and activator of transcription. (869 aa)
GAS6Growth arrest specific 6. (724 aa)
RXFP1Relaxin family peptide receptor 1. (698 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (573 aa)
DDX58DExD/H-box helicase 58. (880 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CD40TNFR-Cys domain-containing protein. (214 aa)
CD4Ig-like domain-containing protein. (264 aa)
CD93CD93 molecule. (508 aa)
TRIM25Tripartite motif containing 25. (648 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (639 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IL6Uncharacterized protein. (350 aa)
VAV2Vav guanine nucleotide exchange factor 2. (854 aa)
CD59UPAR/Ly6 domain-containing protein. (123 aa)
MSNMoesin. (615 aa)
VAV3Vav guanine nucleotide exchange factor 3. (790 aa)
IRF7Interferon regulatory factor 7. (523 aa)
IL-17Uncharacterized protein. (191 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
ENSAPLP00000028410Uncharacterized protein. (157 aa)
MERTKUncharacterized protein. (233 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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