60 items (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	FGFR3	Fibroblast growth factor receptor. (833 aa)
	HOXD11	Homeobox D11. (280 aa)
	FZD5	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (682 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
	CRABP1	Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
	SMAD7	Mothers against decapentaplegic homolog. (369 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (319 aa)
	MGP	Matrix Gla protein. (103 aa)
	SMAD4	Mothers against decapentaplegic homolog. (551 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
	DKK2	Dickkopf_N domain-containing protein. (348 aa)
	DVL1	Dishevelled segment polarity protein 1. (712 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (105 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
	HOXC10	Homeobox C10. (353 aa)
	SHH	Sonic hedgehog signaling molecule. (391 aa)
	HOXC13	Homeobox C13. (203 aa)
	LEF1	Uncharacterized protein. (415 aa)
	FMOD	Fibromodulin. (380 aa)
	TBX4	T-box transcription factor 4. (495 aa)
	HOXD10	Homeobox D10. (339 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (276 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	AXIN2	DIX domain-containing protein. (274 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	PDGFC	Platelet derived growth factor C. (345 aa)
	PTCH1	Patched 1. (1412 aa)
	WIF1	WNT inhibitory factor 1. (467 aa)
	HOXB8	Homeobox B8. (242 aa)
	HOXB6	Homeobox B6. (233 aa)
	HOXB5	Homeobox B5. (264 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	PITX2	Homeobox protein. (334 aa)
	FGFR1	Fibroblast growth factor receptor. (813 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	EDAR	Ectodysplasin A receptor. (447 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
	HOXB3	Homeobox B3. (399 aa)
	HOXB2	Homeobox B2. (381 aa)
	HHIP	Hedgehog interacting protein. (697 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (271 aa)
	HOXB4	Homeobox B4. (347 aa)
	HOXC8	Homeobox C8. (242 aa)
	TCF7L1	Uncharacterized protein. (415 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	PTCH2	SSD domain-containing protein. (888 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSAPLP00000010867	ENSAPLP00000029585	DIX domain-containing protein.	Bone morphogenetic protein 4.	0.526
AXIN2	DKK1	ENSAPLP00000010867	ENSAPLP00000021199	DIX domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 1.	0.720
AXIN2	DKK2	ENSAPLP00000010867	ENSAPLP00000005731	DIX domain-containing protein.	Dickkopf_N domain-containing protein.	0.428
AXIN2	DVL1	ENSAPLP00000010867	ENSAPLP00000005878	DIX domain-containing protein.	Dishevelled segment polarity protein 1.	0.976
AXIN2	EDAR	ENSAPLP00000010867	ENSAPLP00000015865	DIX domain-containing protein.	Ectodysplasin A receptor.	0.447
AXIN2	FGF1	ENSAPLP00000010867	ENSAPLP00000006395	DIX domain-containing protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.413
AXIN2	FGF12	ENSAPLP00000010867	ENSAPLP00000028915	DIX domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
AXIN2	FGF14	ENSAPLP00000010867	ENSAPLP00000024343	DIX domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
AXIN2	FGF18	ENSAPLP00000010867	ENSAPLP00000009824	DIX domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.456
AXIN2	FGF9	ENSAPLP00000010867	ENSAPLP00000010581	DIX domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.456
AXIN2	FZD1	ENSAPLP00000010867	ENSAPLP00000006131	DIX domain-containing protein.	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.582
AXIN2	FZD2	ENSAPLP00000010867	ENSAPLP00000001604	DIX domain-containing protein.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.566
AXIN2	FZD3	ENSAPLP00000010867	ENSAPLP00000014510	DIX domain-containing protein.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.444
AXIN2	FZD4	ENSAPLP00000010867	ENSAPLP00000031545	DIX domain-containing protein.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.519
AXIN2	FZD5	ENSAPLP00000010867	ENSAPLP00000032188	DIX domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.507
AXIN2	FZD7	ENSAPLP00000010867	ENSAPLP00000001053	DIX domain-containing protein.	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	0.575
AXIN2	FZD8	ENSAPLP00000010867	ENSAPLP00000030062	DIX domain-containing protein.	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.539
AXIN2	LEF1	ENSAPLP00000010867	ENSAPLP00000007165	DIX domain-containing protein.	Uncharacterized protein.	0.731
AXIN2	SHH	ENSAPLP00000010867	ENSAPLP00000006846	DIX domain-containing protein.	Sonic hedgehog signaling molecule.	0.457
AXIN2	TCF7L1	ENSAPLP00000010867	ENSAPLP00000021808	DIX domain-containing protein.	Uncharacterized protein.	0.526