(17 nodes) (2018) GLK-IKKbeta signaling induces dimerization and translocation of the AhR-RORgammat complex in IL-17A induction and autoimmune disease. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
	ENSAPLP00000032061	Uncharacterized protein. (900 aa)
	IRF4	Interferon regulatory factor 4. (446 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	AHR	Uncharacterized protein. (834 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (126 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	LCK	Tyrosine-protein kinase. (507 aa)
	SGK1	Non-specific serine/threonine protein kinase. (526 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	IL6	Uncharacterized protein. (350 aa)
	ENSAPLP00000023999	PAS domain-containing protein. (956 aa)
	ALB	Uncharacterized protein. (592 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	KLF4	Kruppel like factor 4. (463 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CD4	ENSAPLP00000025530	ENSAPLP00000018005	Uncharacterized protein.	Ig-like domain-containing protein.	0.792
ALB	IFNG	ENSAPLP00000025530	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.697
ALB	IL6	ENSAPLP00000025530	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.803
ALB	STAT3	ENSAPLP00000025530	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.426
BATF	IRF4	ENSAPLP00000027804	ENSAPLP00000030637	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.640
BATF	STAT3	ENSAPLP00000027804	ENSAPLP00000007496	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.568
CD4	ALB	ENSAPLP00000018005	ENSAPLP00000025530	Ig-like domain-containing protein.	Uncharacterized protein.	0.792
CD4	ENSAPLP00000028410	ENSAPLP00000018005	ENSAPLP00000028410	Ig-like domain-containing protein.	Uncharacterized protein.	0.632
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	IRF4	ENSAPLP00000018005	ENSAPLP00000030637	Ig-like domain-containing protein.	Interferon regulatory factor 4.	0.520
CD4	LCK	ENSAPLP00000018005	ENSAPLP00000013699	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.996
CD4	STAT1	ENSAPLP00000018005	ENSAPLP00000013135	Ig-like domain-containing protein.	Signal transducer and activator of transcription.	0.806
CD4	STAT3	ENSAPLP00000018005	ENSAPLP00000007496	Ig-like domain-containing protein.	Signal transducer and activator of transcription.	0.800
ENSAPLP00000028410	CD4	ENSAPLP00000028410	ENSAPLP00000018005	Uncharacterized protein.	Ig-like domain-containing protein.	0.632
ENSAPLP00000028410	IFNG	ENSAPLP00000028410	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.970
ENSAPLP00000028410	IL6	ENSAPLP00000028410	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSAPLP00000028410	STAT1	ENSAPLP00000028410	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.707
ENSAPLP00000028410	STAT3	ENSAPLP00000028410	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.468
IFNG	ALB	ENSAPLP00000012661	ENSAPLP00000025530	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.697