(24 nodes) (2019) SLAMF6 in health and disease: Implications for therapeutic targeting. network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LYN	Tyrosine-protein kinase. (535 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (237 aa)
	CD180	CD180 molecule. (660 aa)
	BECN1	Uncharacterized protein. (452 aa)
	ZAP70	Tyrosine-protein kinase. (607 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	EOMES	Eomesodermin. (746 aa)
	GRB2	Growth factor receptor bound protein 2. (203 aa)
	CD81	Tetraspanin. (467 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	XIAP	X-linked inhibitor of apoptosis. (493 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	IL6	Uncharacterized protein. (350 aa)
	KLRG1	Killer cell lectin like receptor G1. (173 aa)
	CD40	TNFR-Cys domain-containing protein. (214 aa)
	CXCL12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (165 aa)
	FYN	Tyrosine-protein kinase. (534 aa)
	LCK	Tyrosine-protein kinase. (507 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	TLR4	Toll like receptor 4. (843 aa)
	IL4	Uncharacterized protein. (136 aa)
	PLCG2	Phosphoinositide phospholipase C. (1086 aa)
	UVRAG	UV radiation resistance associated. (702 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BECN1	MYD88	ENSAPLP00000004076	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.753
BECN1	UVRAG	ENSAPLP00000004076	ENSAPLP00000010379	Uncharacterized protein.	UV radiation resistance associated.	0.999
BECN1	XIAP	ENSAPLP00000004076	ENSAPLP00000024710	Uncharacterized protein.	X-linked inhibitor of apoptosis.	0.547
CD180	TLR4	ENSAPLP00000004226	ENSAPLP00000012401	CD180 molecule.	Toll like receptor 4.	0.534
CD4	CD40	ENSAPLP00000018005	ENSAPLP00000016411	Ig-like domain-containing protein.	TNFR-Cys domain-containing protein.	0.938
CD4	CD81	ENSAPLP00000018005	ENSAPLP00000029304	Ig-like domain-containing protein.	Tetraspanin.	0.604
CD4	CXCL12	ENSAPLP00000018005	ENSAPLP00000015191	Ig-like domain-containing protein.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.714
CD4	EOMES	ENSAPLP00000018005	ENSAPLP00000030390	Ig-like domain-containing protein.	Eomesodermin.	0.611
CD4	FASLG	ENSAPLP00000018005	ENSAPLP00000004898	Ig-like domain-containing protein.	Fas ligand; Belongs to the tumor necrosis factor family.	0.468
CD4	FYN	ENSAPLP00000018005	ENSAPLP00000014801	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.694
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL4	ENSAPLP00000018005	ENSAPLP00000011598	Ig-like domain-containing protein.	Uncharacterized protein.	0.957
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	KLRG1	ENSAPLP00000018005	ENSAPLP00000016716	Ig-like domain-containing protein.	Killer cell lectin like receptor G1.	0.441
CD4	LCK	ENSAPLP00000018005	ENSAPLP00000013699	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.996
CD4	LYN	ENSAPLP00000018005	ENSAPLP00000005775	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.804
CD4	MYD88	ENSAPLP00000018005	ENSAPLP00000028214	Ig-like domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.801
CD4	SYK	ENSAPLP00000018005	ENSAPLP00000003149	Ig-like domain-containing protein.	Spleen associated tyrosine kinase.	0.683
CD4	TLR4	ENSAPLP00000018005	ENSAPLP00000012401	Ig-like domain-containing protein.	Toll like receptor 4.	0.837
CD4	ZAP70	ENSAPLP00000018005	ENSAPLP00000001899	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.891