(18 nodes) (2018) JAK Inhibitors in Rheumatology: Implications for Paediatric Syndromes? network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNFAIP3	TNF alpha induced protein 3. (870 aa)
	MAVS	CARD_2 domain-containing protein. (619 aa)
	IL18	Interleukin-18. (197 aa)
	ADA	Adenosine deaminase. (359 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	POLA1	DNA polymerase. (1490 aa)
	PTPN22	Protein tyrosine phosphatase non-receptor type 22. (803 aa)
	JAK1	Tyrosine-protein kinase. (1152 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	EXO1	Exonuclease 1. (808 aa)
	JAK3	Uncharacterized protein. (501 aa)
	CGAS	Cyclic GMP-AMP synthase. (545 aa)
	IL6	Uncharacterized protein. (350 aa)
	STING1	Transmembrane protein 173. (420 aa)
	STAT4	Signal transducer and activator of transcription. (757 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	EXO1	ENSAPLP00000008441	ENSAPLP00000014890	Adenosine deaminase.	Exonuclease 1.	0.482
ADA	POLA1	ENSAPLP00000008441	ENSAPLP00000008748	Adenosine deaminase.	DNA polymerase.	0.455
CGAS	ENSAPLP00000028410	ENSAPLP00000018895	ENSAPLP00000028410	Cyclic GMP-AMP synthase.	Uncharacterized protein.	0.507
CGAS	IRF7	ENSAPLP00000018895	ENSAPLP00000026565	Cyclic GMP-AMP synthase.	Interferon regulatory factor 7.	0.504
CGAS	MAVS	ENSAPLP00000018895	ENSAPLP00000002790	Cyclic GMP-AMP synthase.	CARD_2 domain-containing protein.	0.681
CGAS	STAT1	ENSAPLP00000018895	ENSAPLP00000013135	Cyclic GMP-AMP synthase.	Signal transducer and activator of transcription.	0.440
CGAS	STING1	ENSAPLP00000018895	ENSAPLP00000021852	Cyclic GMP-AMP synthase.	Transmembrane protein 173.	0.645
CGAS	TLR3	ENSAPLP00000018895	ENSAPLP00000008663	Cyclic GMP-AMP synthase.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.515
ENSAPLP00000028410	CGAS	ENSAPLP00000028410	ENSAPLP00000018895	Uncharacterized protein.	Cyclic GMP-AMP synthase.	0.507
ENSAPLP00000028410	IL18	ENSAPLP00000028410	ENSAPLP00000005562	Uncharacterized protein.	Interleukin-18.	0.517
ENSAPLP00000028410	IL6	ENSAPLP00000028410	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSAPLP00000028410	IRF7	ENSAPLP00000028410	ENSAPLP00000026565	Uncharacterized protein.	Interferon regulatory factor 7.	0.961
ENSAPLP00000028410	JAK1	ENSAPLP00000028410	ENSAPLP00000011906	Uncharacterized protein.	Tyrosine-protein kinase.	0.473
ENSAPLP00000028410	MAVS	ENSAPLP00000028410	ENSAPLP00000002790	Uncharacterized protein.	CARD_2 domain-containing protein.	0.632
ENSAPLP00000028410	STAT1	ENSAPLP00000028410	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.707
ENSAPLP00000028410	STAT4	ENSAPLP00000028410	ENSAPLP00000024437	Uncharacterized protein.	Signal transducer and activator of transcription.	0.566
ENSAPLP00000028410	TLR3	ENSAPLP00000028410	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.795
EXO1	ADA	ENSAPLP00000014890	ENSAPLP00000008441	Exonuclease 1.	Adenosine deaminase.	0.482
EXO1	POLA1	ENSAPLP00000014890	ENSAPLP00000008748	Exonuclease 1.	DNA polymerase.	0.924
EXO1	TLR3	ENSAPLP00000014890	ENSAPLP00000008663	Exonuclease 1.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.438