(10 nodes) (2019) Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling. network (Anas platyrhynchos)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	HMGB1	High mobility group box 1. (281 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TLR4	Toll like receptor 4. (843 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	IL10	Interleukin 10. (177 aa)
	PRKCE	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
	IL6	Uncharacterized protein. (350 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (535 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	SIRT1	Sirtuin 1. (777 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HMGB1	IL10	ENSAPLP00000023852	ENSAPLP00000015242	High mobility group box 1.	Interleukin 10.	0.511
HMGB1	IL6	ENSAPLP00000023852	ENSAPLP00000020478	High mobility group box 1.	Uncharacterized protein.	0.738
HMGB1	MYD88	ENSAPLP00000023852	ENSAPLP00000028214	High mobility group box 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.627
HMGB1	TLR2	ENSAPLP00000023852	ENSAPLP00000011131	High mobility group box 1.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.660
HMGB1	TLR4	ENSAPLP00000023852	ENSAPLP00000012401	High mobility group box 1.	Toll like receptor 4.	0.985
IL10	HMGB1	ENSAPLP00000015242	ENSAPLP00000023852	Interleukin 10.	High mobility group box 1.	0.511
IL10	IL6	ENSAPLP00000015242	ENSAPLP00000020478	Interleukin 10.	Uncharacterized protein.	0.975
IL10	MYD88	ENSAPLP00000015242	ENSAPLP00000028214	Interleukin 10.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.784
IL10	STAT1	ENSAPLP00000015242	ENSAPLP00000013135	Interleukin 10.	Signal transducer and activator of transcription.	0.823
IL10	TLR2	ENSAPLP00000015242	ENSAPLP00000011131	Interleukin 10.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.607
IL10	TLR4	ENSAPLP00000015242	ENSAPLP00000012401	Interleukin 10.	Toll like receptor 4.	0.937
IL6	HMGB1	ENSAPLP00000020478	ENSAPLP00000023852	Uncharacterized protein.	High mobility group box 1.	0.738
IL6	IL10	ENSAPLP00000020478	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.975
IL6	MYD88	ENSAPLP00000020478	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.878
IL6	SIRT1	ENSAPLP00000020478	ENSAPLP00000030709	Uncharacterized protein.	Sirtuin 1.	0.530
IL6	STAT1	ENSAPLP00000020478	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.873
IL6	TLR2	ENSAPLP00000020478	ENSAPLP00000011131	Uncharacterized protein.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.667
IL6	TLR4	ENSAPLP00000020478	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.957
MYD88	HMGB1	ENSAPLP00000028214	ENSAPLP00000023852	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	High mobility group box 1.	0.627
MYD88	IL10	ENSAPLP00000028214	ENSAPLP00000015242	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Interleukin 10.	0.784