(23 nodes) (2019) AIRE expression controls the peripheral selection of autoreactive B cells. network (Anas platyrhynchos)

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second shell of interactors

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Predicted Interactions

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Your Input:
	TNFRSF13B	TACI-CRD2 domain-containing protein. (363 aa)
	GAD1	Glutamate decarboxylase 1. (563 aa)
	GAD2	Glutamate decarboxylase 2. (585 aa)
	ADA	Adenosine deaminase. (359 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1280 aa)
	IL7	Uncharacterized protein. (144 aa)
	CD3E	CD3e molecule. (187 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1041 aa)
	IL17B	Interleukin 17B. (166 aa)
	IL4	Uncharacterized protein. (136 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
	AICDA	Activation induced cytidine deaminase. (203 aa)
	IL10	Interleukin 10. (177 aa)
	TPO	Thyroid peroxidase. (846 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	IL6	Uncharacterized protein. (350 aa)
	DOCK8	DUF3398 domain-containing protein. (503 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (541 aa)
	CD86	CD86 molecule. (341 aa)
	BMP4	Bone morphogenetic protein 4. (407 aa)
	IL22	Interleukin 22. (197 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	CD4	ENSAPLP00000013772	ENSAPLP00000018005	Activation induced cytidine deaminase.	Ig-like domain-containing protein.	0.514
AICDA	CD86	ENSAPLP00000013772	ENSAPLP00000026026	Activation induced cytidine deaminase.	CD86 molecule.	0.411
AICDA	IL4	ENSAPLP00000013772	ENSAPLP00000011598	Activation induced cytidine deaminase.	Uncharacterized protein.	0.718
AICDA	RAG1	ENSAPLP00000013772	ENSAPLP00000011498	Activation induced cytidine deaminase.	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]	0.514
BMP4	INS	ENSAPLP00000029585	ENSAPLP00000012854	Bone morphogenetic protein 4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.687
CCR6	CD4	ENSAPLP00000018429	ENSAPLP00000018005	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Ig-like domain-containing protein.	0.797
CCR6	CD86	ENSAPLP00000018429	ENSAPLP00000026026	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	CD86 molecule.	0.505
CCR6	IFNG	ENSAPLP00000018429	ENSAPLP00000012661	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.478
CCR6	IL10	ENSAPLP00000018429	ENSAPLP00000015242	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Interleukin 10.	0.544
CCR6	IL22	ENSAPLP00000018429	ENSAPLP00000032710	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Interleukin 22.	0.689
CCR6	IL4	ENSAPLP00000018429	ENSAPLP00000011598	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.504
CCR6	IL6	ENSAPLP00000018429	ENSAPLP00000020478	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.485
CD3E	CD4	ENSAPLP00000010440	ENSAPLP00000018005	CD3e molecule.	Ig-like domain-containing protein.	0.910
CD3E	CD86	ENSAPLP00000010440	ENSAPLP00000026026	CD3e molecule.	CD86 molecule.	0.476
CD3E	IFNG	ENSAPLP00000010440	ENSAPLP00000012661	CD3e molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.568
CD3E	IL10	ENSAPLP00000010440	ENSAPLP00000015242	CD3e molecule.	Interleukin 10.	0.492
CD3E	IL4	ENSAPLP00000010440	ENSAPLP00000011598	CD3e molecule.	Uncharacterized protein.	0.416
CD4	AICDA	ENSAPLP00000018005	ENSAPLP00000013772	Ig-like domain-containing protein.	Activation induced cytidine deaminase.	0.514
CD4	CCR6	ENSAPLP00000018005	ENSAPLP00000018429	Ig-like domain-containing protein.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.797
CD4	CD3E	ENSAPLP00000018005	ENSAPLP00000010440	Ig-like domain-containing protein.	CD3e molecule.	0.910