STRINGSTRING
JAK2 JAK2 HES4 HES4 SIRT3 SIRT3 STAT3 STAT3 HMOX1 HMOX1 CASP9 CASP9 PPARG PPARG RYR2 RYR2 HK2 HK2 FUNDC1 FUNDC1 U3IXC3_ANAPP U3IXC3_ANAPP U3IXI7_ANAPP U3IXI7_ANAPP MFN2 MFN2 TLR4 TLR4 CASP8 CASP8 CASP3 CASP3 U3J6D9_ANAPP U3J6D9_ANAPP VDAC1 VDAC1 IL10 IL10 PTEN PTEN BCL2 BCL2 IL6 IL6 PRKD1 PRKD1 BDNF BDNF MCL1 MCL1 SIRT1 SIRT1 CRYZ CRYZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK2Tyrosine-protein kinase. (1130 aa)
HES4Hes family bHLH transcription factor 4. (317 aa)
SIRT3Sirtuin 3. (439 aa)
STAT3Signal transducer and activator of transcription. (942 aa)
HMOX1Heme oxygenase 1. (296 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (446 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (450 aa)
RYR2Ryanodine receptor 2. (4940 aa)
HK2Hexokinase 2. (744 aa)
FUNDC1FUN14 domain containing 1. (170 aa)
U3IXC3_ANAPPSERPIN domain-containing protein; Belongs to the serpin family. (423 aa)
U3IXI7_ANAPPSERPIN domain-containing protein; Belongs to the serpin family. (422 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
TLR4Toll like receptor 4. (843 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (466 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (306 aa)
U3J6D9_ANAPPUncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
IL10Interleukin 10. (177 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
IL6Uncharacterized protein. (350 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (897 aa)
BDNFBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (263 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (325 aa)
SIRT1Sirtuin 1. (777 aa)
CRYZCrystallin zeta. (331 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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