(8 nodes) (2020) Targeted Knockout of MDA5 and TLR3 in the DF-1 Chicken Fibroblast Cell Line Impairs Innate Immune Response Against RNA Ligands. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	ACTB	Actin beta. (332 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (721 aa)
	ACTB-2	Uncharacterized protein. (376 aa)
	ALB	Uncharacterized protein. (592 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSAPLP00000009880	ENSAPLP00000025530	Actin beta.	Uncharacterized protein.	0.614
ACTB	TLR3	ENSAPLP00000009880	ENSAPLP00000008663	Actin beta.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.472
ACTB-2	ALB	ENSAPLP00000022136	ENSAPLP00000025530	Uncharacterized protein.	Uncharacterized protein.	0.614
ACTB-2	TLR3	ENSAPLP00000022136	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.472
ALB	ACTB	ENSAPLP00000025530	ENSAPLP00000009880	Uncharacterized protein.	Actin beta.	0.614
ALB	ACTB-2	ENSAPLP00000025530	ENSAPLP00000022136	Uncharacterized protein.	Uncharacterized protein.	0.614
ENSAPLP00000028410	IRF7	ENSAPLP00000028410	ENSAPLP00000026565	Uncharacterized protein.	Interferon regulatory factor 7.	0.961
ENSAPLP00000028410	MX1	ENSAPLP00000028410	ENSAPLP00000015901	Uncharacterized protein.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.622
ENSAPLP00000028410	TLR3	ENSAPLP00000028410	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.795
ENSAPLP00000028410	TLR7	ENSAPLP00000028410	ENSAPLP00000003630	Uncharacterized protein.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.698
IRF7	ENSAPLP00000028410	ENSAPLP00000026565	ENSAPLP00000028410	Interferon regulatory factor 7.	Uncharacterized protein.	0.961
IRF7	MX1	ENSAPLP00000026565	ENSAPLP00000015901	Interferon regulatory factor 7.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.737
IRF7	TLR3	ENSAPLP00000026565	ENSAPLP00000008663	Interferon regulatory factor 7.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.810
IRF7	TLR7	ENSAPLP00000026565	ENSAPLP00000003630	Interferon regulatory factor 7.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.729
MX1	ENSAPLP00000028410	ENSAPLP00000015901	ENSAPLP00000028410	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Uncharacterized protein.	0.622
MX1	IRF7	ENSAPLP00000015901	ENSAPLP00000026565	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Interferon regulatory factor 7.	0.737
MX1	TLR3	ENSAPLP00000015901	ENSAPLP00000008663	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.766
MX1	TLR7	ENSAPLP00000015901	ENSAPLP00000003630	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.565
TLR3	ACTB	ENSAPLP00000008663	ENSAPLP00000009880	Toll like receptor 3; Belongs to the Toll-like receptor family.	Actin beta.	0.472
TLR3	ACTB-2	ENSAPLP00000008663	ENSAPLP00000022136	Toll like receptor 3; Belongs to the Toll-like receptor family.	Uncharacterized protein.	0.472