(14 nodes) (2021) Tissue-specific activation of Myd88-dependent pathways governs disease severity in primary Sjoegrens syndrome. network (Anas platyrhynchos)

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second shell of interactors

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Your Input:
	DCN	Decorin; May affect the rate of fibrils formation. (360 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	TLR4	Toll like receptor 4. (843 aa)
	IL4	Uncharacterized protein. (136 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (802 aa)
	LYN	Tyrosine-protein kinase. (535 aa)
	IL18	Interleukin-18. (197 aa)
	IL-17	Uncharacterized protein. (191 aa)
	CD86	CD86 molecule. (341 aa)
	IL6	Uncharacterized protein. (350 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	CD44	CD44 molecule (Indian blood group). (645 aa)
	IL10	Interleukin 10. (177 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD44	ENSAPLP00000018005	ENSAPLP00000016839	Ig-like domain-containing protein.	CD44 molecule (Indian blood group).	0.951
CD4	CD86	ENSAPLP00000018005	ENSAPLP00000026026	Ig-like domain-containing protein.	CD86 molecule.	0.966
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL-17	ENSAPLP00000018005	ENSAPLP00000026822	Ig-like domain-containing protein.	Uncharacterized protein.	0.959
CD4	IL10	ENSAPLP00000018005	ENSAPLP00000015242	Ig-like domain-containing protein.	Interleukin 10.	0.959
CD4	IL18	ENSAPLP00000018005	ENSAPLP00000005562	Ig-like domain-containing protein.	Interleukin-18.	0.648
CD4	IL4	ENSAPLP00000018005	ENSAPLP00000011598	Ig-like domain-containing protein.	Uncharacterized protein.	0.957
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	LYN	ENSAPLP00000018005	ENSAPLP00000005775	Ig-like domain-containing protein.	Tyrosine-protein kinase.	0.804
CD4	MYD88	ENSAPLP00000018005	ENSAPLP00000028214	Ig-like domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.801
CD4	TLR4	ENSAPLP00000018005	ENSAPLP00000012401	Ig-like domain-containing protein.	Toll like receptor 4.	0.837
CD44	CD4	ENSAPLP00000016839	ENSAPLP00000018005	CD44 molecule (Indian blood group).	Ig-like domain-containing protein.	0.951
CD44	CD86	ENSAPLP00000016839	ENSAPLP00000026026	CD44 molecule (Indian blood group).	CD86 molecule.	0.812
CD44	IFNG	ENSAPLP00000016839	ENSAPLP00000012661	CD44 molecule (Indian blood group).	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.728
CD44	IL-17	ENSAPLP00000016839	ENSAPLP00000026822	CD44 molecule (Indian blood group).	Uncharacterized protein.	0.763
CD44	IL10	ENSAPLP00000016839	ENSAPLP00000015242	CD44 molecule (Indian blood group).	Interleukin 10.	0.712
CD44	IL4	ENSAPLP00000016839	ENSAPLP00000011598	CD44 molecule (Indian blood group).	Uncharacterized protein.	0.727
CD44	IL6	ENSAPLP00000016839	ENSAPLP00000020478	CD44 molecule (Indian blood group).	Uncharacterized protein.	0.733
CD44	LYN	ENSAPLP00000016839	ENSAPLP00000005775	CD44 molecule (Indian blood group).	Tyrosine-protein kinase.	0.456
CD44	TLR4	ENSAPLP00000016839	ENSAPLP00000012401	CD44 molecule (Indian blood group).	Toll like receptor 4.	0.645