(13 nodes) (2021) Natural Sulfurs Inhibit LPS-Induced Inflammatory Responses through NF-kappaB Signaling in CCD-986Sk Skin Fibroblasts. network (Anas platyrhynchos)

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Your Input:
	JAK2	Tyrosine-protein kinase. (1130 aa)
	IL6	Uncharacterized protein. (350 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	PXDN	Peroxidasin. (1193 aa)
	IL10	Interleukin 10. (177 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	TBP	TATA-box binding protein. (302 aa)
	TLR4	Toll like receptor 4. (843 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	CHEK2	Checkpoint kinase 2. (524 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (450 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (605 aa)
	ENSAPLP00000029472	Uncharacterized protein. (1406 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHEK2	MYD88	ENSAPLP00000009352	ENSAPLP00000028214	Checkpoint kinase 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.424
ENSAPLP00000029472	IFNG	ENSAPLP00000029472	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.676
ENSAPLP00000029472	IL10	ENSAPLP00000029472	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.703
ENSAPLP00000029472	IL6	ENSAPLP00000029472	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.758
ENSAPLP00000029472	PXDN	ENSAPLP00000029472	ENSAPLP00000015658	Uncharacterized protein.	Peroxidasin.	0.616
IFNG	ENSAPLP00000029472	ENSAPLP00000012661	ENSAPLP00000029472	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.676
IFNG	IL10	ENSAPLP00000012661	ENSAPLP00000015242	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin 10.	0.974
IFNG	IL6	ENSAPLP00000012661	ENSAPLP00000020478	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.959
IFNG	JAK2	ENSAPLP00000012661	ENSAPLP00000027035	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.666
IFNG	MYD88	ENSAPLP00000012661	ENSAPLP00000028214	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.702
IFNG	PPARG	ENSAPLP00000012661	ENSAPLP00000008758	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.404
IFNG	PXDN	ENSAPLP00000012661	ENSAPLP00000015658	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Peroxidasin.	0.676
IFNG	TLR2	ENSAPLP00000012661	ENSAPLP00000011131	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.495
IFNG	TLR4	ENSAPLP00000012661	ENSAPLP00000012401	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Toll like receptor 4.	0.783
IL10	ENSAPLP00000029472	ENSAPLP00000015242	ENSAPLP00000029472	Interleukin 10.	Uncharacterized protein.	0.703
IL10	IFNG	ENSAPLP00000015242	ENSAPLP00000012661	Interleukin 10.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.974
IL10	IL6	ENSAPLP00000015242	ENSAPLP00000020478	Interleukin 10.	Uncharacterized protein.	0.975
IL10	MYD88	ENSAPLP00000015242	ENSAPLP00000028214	Interleukin 10.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.784
IL10	PPARG	ENSAPLP00000015242	ENSAPLP00000008758	Interleukin 10.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.682
IL10	PXDN	ENSAPLP00000015242	ENSAPLP00000015658	Interleukin 10.	Peroxidasin.	0.701