(9 nodes) (2021) Lacticaseibacillus rhamnosus Reduces the Pathogenicity of Escherichia coli in Chickens. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (541 aa)
	IL6	Uncharacterized protein. (350 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
	TLR4	Toll like receptor 4. (843 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1182 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGF	IL6	ENSAPLP00000011666	ENSAPLP00000020478	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Uncharacterized protein.	0.710
EGF	INS	ENSAPLP00000011666	ENSAPLP00000012854	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.939
IL6	EGF	ENSAPLP00000020478	ENSAPLP00000011666	Uncharacterized protein.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.710
IL6	INS	ENSAPLP00000020478	ENSAPLP00000012854	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.770
IL6	IRAK4	ENSAPLP00000020478	ENSAPLP00000023092	Uncharacterized protein.	Interleukin 1 receptor associated kinase 4.	0.513
IL6	MYD88	ENSAPLP00000020478	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.878
IL6	TLR2	ENSAPLP00000020478	ENSAPLP00000011131	Uncharacterized protein.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.667
IL6	TLR3	ENSAPLP00000020478	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.869
IL6	TLR4	ENSAPLP00000020478	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.957
IL6	TLR7	ENSAPLP00000020478	ENSAPLP00000003630	Uncharacterized protein.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.855
INS	EGF	ENSAPLP00000012854	ENSAPLP00000011666	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.939
INS	IL6	ENSAPLP00000012854	ENSAPLP00000020478	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.770
INS	TLR4	ENSAPLP00000012854	ENSAPLP00000012401	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Toll like receptor 4.	0.589
IRAK4	IL6	ENSAPLP00000023092	ENSAPLP00000020478	Interleukin 1 receptor associated kinase 4.	Uncharacterized protein.	0.513
IRAK4	MYD88	ENSAPLP00000023092	ENSAPLP00000028214	Interleukin 1 receptor associated kinase 4.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999
IRAK4	TLR2	ENSAPLP00000023092	ENSAPLP00000011131	Interleukin 1 receptor associated kinase 4.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.463
IRAK4	TLR3	ENSAPLP00000023092	ENSAPLP00000008663	Interleukin 1 receptor associated kinase 4.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.794
IRAK4	TLR4	ENSAPLP00000023092	ENSAPLP00000012401	Interleukin 1 receptor associated kinase 4.	Toll like receptor 4.	0.899
IRAK4	TLR7	ENSAPLP00000023092	ENSAPLP00000003630	Interleukin 1 receptor associated kinase 4.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.760
MYD88	IL6	ENSAPLP00000028214	ENSAPLP00000020478	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Uncharacterized protein.	0.878