(23 nodes) (2021) Stem cell therapies for autoimmune hepatitis. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (185 aa)
	IL-17	Uncharacterized protein. (191 aa)
	STAT4	Signal transducer and activator of transcription. (757 aa)
	GOT1	Aspartate aminotransferase. (403 aa)
	IL6	Uncharacterized protein. (350 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	CD34	CD34 molecule. (368 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1151 aa)
	IL10	Interleukin 10. (177 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (306 aa)
	U3J1K3_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1420 aa)
	JAK1	Tyrosine-protein kinase. (1152 aa)
	IL4	Uncharacterized protein. (136 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	IL7	Uncharacterized protein. (144 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	GOT2	Aspartate aminotransferase. (440 aa)
	IL-2	Interleukin; Belongs to the IL-15/IL-21 family. (140 aa)
	HGF	Uncharacterized protein. (183 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CD34	ENSAPLP00000015062	ENSAPLP00000017042	Caspase 3; Belongs to the peptidase C14A family.	CD34 molecule.	0.433
CASP3	CD4	ENSAPLP00000015062	ENSAPLP00000018005	Caspase 3; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.666
CASP3	IFNG	ENSAPLP00000015062	ENSAPLP00000012661	Caspase 3; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.523
CASP3	IL10	ENSAPLP00000015062	ENSAPLP00000015242	Caspase 3; Belongs to the peptidase C14A family.	Interleukin 10.	0.720
CASP3	IL4	ENSAPLP00000015062	ENSAPLP00000011598	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.485
CASP3	IL6	ENSAPLP00000015062	ENSAPLP00000020478	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.788
CASP3	STAT1	ENSAPLP00000015062	ENSAPLP00000013135	Caspase 3; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.523
CASP3	STAT3	ENSAPLP00000015062	ENSAPLP00000007496	Caspase 3; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.721
CD34	CASP3	ENSAPLP00000017042	ENSAPLP00000015062	CD34 molecule.	Caspase 3; Belongs to the peptidase C14A family.	0.433
CD34	CD4	ENSAPLP00000017042	ENSAPLP00000018005	CD34 molecule.	Ig-like domain-containing protein.	0.767
CD34	IFNG	ENSAPLP00000017042	ENSAPLP00000012661	CD34 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.462
CD34	IL10	ENSAPLP00000017042	ENSAPLP00000015242	CD34 molecule.	Interleukin 10.	0.499
CD34	IL4	ENSAPLP00000017042	ENSAPLP00000011598	CD34 molecule.	Uncharacterized protein.	0.511
CD34	IL6	ENSAPLP00000017042	ENSAPLP00000020478	CD34 molecule.	Uncharacterized protein.	0.694
CD34	IL7	ENSAPLP00000017042	ENSAPLP00000008882	CD34 molecule.	Uncharacterized protein.	0.435
CD4	CASP3	ENSAPLP00000018005	ENSAPLP00000015062	Ig-like domain-containing protein.	Caspase 3; Belongs to the peptidase C14A family.	0.666
CD4	CD34	ENSAPLP00000018005	ENSAPLP00000017042	Ig-like domain-containing protein.	CD34 molecule.	0.767
CD4	CTLA4	ENSAPLP00000018005	ENSAPLP00000001417	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte associated protein 4.	0.946
CD4	GOT1	ENSAPLP00000018005	ENSAPLP00000021568	Ig-like domain-containing protein.	Aspartate aminotransferase.	0.416
CD4	GOT2	ENSAPLP00000018005	ENSAPLP00000006507	Ig-like domain-containing protein.	Aspartate aminotransferase.	0.412