(8 nodes) (2021) Rheumatic Manifestations and Diseases From Immune Checkpoint Inhibitors in Cancer Immunotherapy. network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	U3IQV6_ANAPP	Uncharacterized protein. (724 aa)
	EPX	Eosinophil peroxidase. (789 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	IL6	Uncharacterized protein. (350 aa)
	CKB	Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
	IL-17	Uncharacterized protein. (191 aa)
	CD81	Tetraspanin. (467 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (185 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD81	ENSAPLP00000018005	ENSAPLP00000029304	Ig-like domain-containing protein.	Tetraspanin.	0.604
CD4	CTLA4	ENSAPLP00000018005	ENSAPLP00000001417	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte associated protein 4.	0.946
CD4	IL-17	ENSAPLP00000018005	ENSAPLP00000026822	Ig-like domain-containing protein.	Uncharacterized protein.	0.959
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD81	CD4	ENSAPLP00000029304	ENSAPLP00000018005	Tetraspanin.	Ig-like domain-containing protein.	0.604
CTLA4	CD4	ENSAPLP00000001417	ENSAPLP00000018005	Cytotoxic T-lymphocyte associated protein 4.	Ig-like domain-containing protein.	0.946
CTLA4	IL-17	ENSAPLP00000001417	ENSAPLP00000026822	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.675
CTLA4	IL6	ENSAPLP00000001417	ENSAPLP00000020478	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.647
EPX	IL6	ENSAPLP00000010607	ENSAPLP00000020478	Eosinophil peroxidase.	Uncharacterized protein.	0.591
EPX	U3IQV6_ANAPP	ENSAPLP00000010607	ENSAPLP00000009629	Eosinophil peroxidase.	Uncharacterized protein.	0.902
IL-17	CD4	ENSAPLP00000026822	ENSAPLP00000018005	Uncharacterized protein.	Ig-like domain-containing protein.	0.959
IL-17	CTLA4	ENSAPLP00000026822	ENSAPLP00000001417	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.675
IL-17	IL6	ENSAPLP00000026822	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.959
IL-17	U3IQV6_ANAPP	ENSAPLP00000026822	ENSAPLP00000009629	Uncharacterized protein.	Uncharacterized protein.	0.545
IL6	CD4	ENSAPLP00000020478	ENSAPLP00000018005	Uncharacterized protein.	Ig-like domain-containing protein.	0.961
IL6	CTLA4	ENSAPLP00000020478	ENSAPLP00000001417	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.647
IL6	EPX	ENSAPLP00000020478	ENSAPLP00000010607	Uncharacterized protein.	Eosinophil peroxidase.	0.591
IL6	IL-17	ENSAPLP00000020478	ENSAPLP00000026822	Uncharacterized protein.	Uncharacterized protein.	0.959
IL6	U3IQV6_ANAPP	ENSAPLP00000020478	ENSAPLP00000009629	Uncharacterized protein.	Uncharacterized protein.	0.751
U3IQV6_ANAPP	EPX	ENSAPLP00000009629	ENSAPLP00000010607	Uncharacterized protein.	Eosinophil peroxidase.	0.902