(17 nodes) (2021) Licorice (Glycyrrhiza glabra) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review. network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	HMGB1	High mobility group box 1. (281 aa)
	IL6	Uncharacterized protein. (350 aa)
	HSD11B2	Hydroxysteroid 11-beta dehydrogenase 2. (624 aa)
	SKP2	S-phase kinase associated protein 2. (671 aa)
	CCL5	C-C motif chemokine. (90 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1151 aa)
	IL10	Interleukin 10. (177 aa)
	ACE2	Angiotensin-converting enzyme. (653 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1420 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	TLR4	Toll like receptor 4. (843 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	BECN1	Uncharacterized protein. (452 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (820 aa)
	IL18	Interleukin-18. (197 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	IFNG	ENSAPLP00000014389	ENSAPLP00000012661	Angiotensin-converting enzyme.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.427
ACE2	IL10	ENSAPLP00000014389	ENSAPLP00000015242	Angiotensin-converting enzyme.	Interleukin 10.	0.673
ACE2	IL6	ENSAPLP00000014389	ENSAPLP00000020478	Angiotensin-converting enzyme.	Uncharacterized protein.	0.815
BECN1	HMGB1	ENSAPLP00000004076	ENSAPLP00000023852	Uncharacterized protein.	High mobility group box 1.	0.942
BECN1	IL18	ENSAPLP00000004076	ENSAPLP00000005562	Uncharacterized protein.	Interleukin-18.	0.415
CCL5	ENSAPLP00000028410	ENSAPLP00000017309	ENSAPLP00000028410	C-C motif chemokine.	Uncharacterized protein.	0.456
CCL5	IFNG	ENSAPLP00000017309	ENSAPLP00000012661	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.748
CCL5	IL10	ENSAPLP00000017309	ENSAPLP00000015242	C-C motif chemokine.	Interleukin 10.	0.826
CCL5	IL18	ENSAPLP00000017309	ENSAPLP00000005562	C-C motif chemokine.	Interleukin-18.	0.529
CCL5	IL6	ENSAPLP00000017309	ENSAPLP00000020478	C-C motif chemokine.	Uncharacterized protein.	0.860
CCL5	STAT1	ENSAPLP00000017309	ENSAPLP00000013135	C-C motif chemokine.	Signal transducer and activator of transcription.	0.542
CCL5	STAT3	ENSAPLP00000017309	ENSAPLP00000007496	C-C motif chemokine.	Signal transducer and activator of transcription.	0.555
CCL5	TLR4	ENSAPLP00000017309	ENSAPLP00000012401	C-C motif chemokine.	Toll like receptor 4.	0.511
ENSAPLP00000028410	CCL5	ENSAPLP00000028410	ENSAPLP00000017309	Uncharacterized protein.	C-C motif chemokine.	0.456
ENSAPLP00000028410	IFNG	ENSAPLP00000028410	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.970
ENSAPLP00000028410	IL10	ENSAPLP00000028410	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.672
ENSAPLP00000028410	IL18	ENSAPLP00000028410	ENSAPLP00000005562	Uncharacterized protein.	Interleukin-18.	0.517
ENSAPLP00000028410	IL6	ENSAPLP00000028410	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSAPLP00000028410	STAT1	ENSAPLP00000028410	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.707
ENSAPLP00000028410	STAT3	ENSAPLP00000028410	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.468