(23 nodes) (2022) Multiple early factors anticipate post-acute COVID-19 sequelae. network (Anas platyrhynchos)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

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Your Input:
	CXCR5	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (116 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (223 aa)
	CD79B	CD79b molecule. (220 aa)
	IL18	Interleukin-18. (197 aa)
	LEF1	Uncharacterized protein. (415 aa)
	IL7	Uncharacterized protein. (144 aa)
	IL4	Uncharacterized protein. (136 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1182 aa)
	ATM	Non-specific serine/threonine protein kinase. (2967 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	CTSL	Uncharacterized protein; Belongs to the peptidase C1 family. (338 aa)
	ACE2	Angiotensin-converting enzyme. (653 aa)
	IL10	Interleukin 10. (177 aa)
	PXDN	Peroxidasin. (1193 aa)
	SST	Somatostatin domain-containing protein. (116 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (721 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	IL6	Uncharacterized protein. (350 aa)
	RORC	RAR related orphan receptor C. (658 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	ENSAPLP00000029472	Uncharacterized protein. (1406 aa)
	TCF7	Transcription factor 7. (439 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CD4	ENSAPLP00000014389	ENSAPLP00000018005	Angiotensin-converting enzyme.	Ig-like domain-containing protein.	0.682
ACE2	CTSL	ENSAPLP00000014389	ENSAPLP00000014121	Angiotensin-converting enzyme.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.765
ACE2	IFNG	ENSAPLP00000014389	ENSAPLP00000012661	Angiotensin-converting enzyme.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.427
ACE2	IL10	ENSAPLP00000014389	ENSAPLP00000015242	Angiotensin-converting enzyme.	Interleukin 10.	0.673
ACE2	IL6	ENSAPLP00000014389	ENSAPLP00000020478	Angiotensin-converting enzyme.	Uncharacterized protein.	0.815
ACE2	IL7	ENSAPLP00000014389	ENSAPLP00000008882	Angiotensin-converting enzyme.	Uncharacterized protein.	0.433
CD4	ACE2	ENSAPLP00000018005	ENSAPLP00000014389	Ig-like domain-containing protein.	Angiotensin-converting enzyme.	0.682
CD4	CD79B	ENSAPLP00000018005	ENSAPLP00000004424	Ig-like domain-containing protein.	CD79b molecule.	0.500
CD4	CXCR5	ENSAPLP00000018005	ENSAPLP00000000175	Ig-like domain-containing protein.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.870
CD4	ENSAPLP00000029472	ENSAPLP00000018005	ENSAPLP00000029472	Ig-like domain-containing protein.	Uncharacterized protein.	0.752
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL10	ENSAPLP00000018005	ENSAPLP00000015242	Ig-like domain-containing protein.	Interleukin 10.	0.959
CD4	IL15	ENSAPLP00000018005	ENSAPLP00000004404	Ig-like domain-containing protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.811
CD4	IL18	ENSAPLP00000018005	ENSAPLP00000005562	Ig-like domain-containing protein.	Interleukin-18.	0.648
CD4	IL4	ENSAPLP00000018005	ENSAPLP00000011598	Ig-like domain-containing protein.	Uncharacterized protein.	0.957
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	IL7	ENSAPLP00000018005	ENSAPLP00000008882	Ig-like domain-containing protein.	Uncharacterized protein.	0.782
CD4	MX1	ENSAPLP00000018005	ENSAPLP00000015901	Ig-like domain-containing protein.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.437
CD4	PXDN	ENSAPLP00000018005	ENSAPLP00000015658	Ig-like domain-containing protein.	Peroxidasin.	0.749
CD4	TRAF6	ENSAPLP00000018005	ENSAPLP00000027926	Ig-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.438