(26 nodes) (2022) Investigating immunoregulatory effects of myeloid cell autophagy in acute and chronic inflammation. network (Anas platyrhynchos)

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Known Interactions

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Predicted Interactions

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Your Input:
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	IL22	Interleukin 22. (197 aa)
	ENSAPLP00000029472	Uncharacterized protein. (1406 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	IL-17	Uncharacterized protein. (191 aa)
	ALB	Uncharacterized protein. (592 aa)
	RUBCN	Rubicon autophagy regulator. (466 aa)
	BECN1	Uncharacterized protein. (452 aa)
	MIF	Uncharacterized protein. (115 aa)
	IL18	Interleukin-18. (197 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	UVRAG	UV radiation resistance associated. (702 aa)
	TLR4	Toll like receptor 4. (843 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	ATG16L1	WD_REPEATS_REGION domain-containing protein. (608 aa)
	IL6	Uncharacterized protein. (350 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (735 aa)
	MAP1LC3B	Uncharacterized protein. (125 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (315 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	IL10	Interleukin 10. (177 aa)
	LCK	Tyrosine-protein kinase. (507 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (753 aa)
	PXDN	Peroxidasin. (1193 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CD4	ENSAPLP00000025530	ENSAPLP00000018005	Uncharacterized protein.	Ig-like domain-containing protein.	0.792
ALB	ENSAPLP00000029472	ENSAPLP00000025530	ENSAPLP00000029472	Uncharacterized protein.	Uncharacterized protein.	0.913
ALB	IFNG	ENSAPLP00000025530	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.697
ALB	IL-17	ENSAPLP00000025530	ENSAPLP00000026822	Uncharacterized protein.	Uncharacterized protein.	0.595
ALB	IL10	ENSAPLP00000025530	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.720
ALB	IL6	ENSAPLP00000025530	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.803
ALB	PXDN	ENSAPLP00000025530	ENSAPLP00000015658	Uncharacterized protein.	Peroxidasin.	0.913
ALB	TLR4	ENSAPLP00000025530	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.601
ATG16L1	ATG5	ENSAPLP00000013185	ENSAPLP00000018253	WD_REPEATS_REGION domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG16L1	ATG7	ENSAPLP00000013185	ENSAPLP00000019209	WD_REPEATS_REGION domain-containing protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.941
ATG16L1	BECN1	ENSAPLP00000013185	ENSAPLP00000004076	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.930
ATG16L1	MAP1LC3B	ENSAPLP00000013185	ENSAPLP00000018470	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.803
ATG16L1	ULK1	ENSAPLP00000013185	ENSAPLP00000014667	WD_REPEATS_REGION domain-containing protein.	Unc-51 like autophagy activating kinase 1.	0.762
ATG16L1	UVRAG	ENSAPLP00000013185	ENSAPLP00000010379	WD_REPEATS_REGION domain-containing protein.	UV radiation resistance associated.	0.611
ATG5	ATG16L1	ENSAPLP00000018253	ENSAPLP00000013185	Autophagy protein 5; Involved in autophagic vesicle formation.	WD_REPEATS_REGION domain-containing protein.	0.999
ATG5	ATG7	ENSAPLP00000018253	ENSAPLP00000019209	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG5	BECN1	ENSAPLP00000018253	ENSAPLP00000004076	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.982
ATG5	MAP1LC3B	ENSAPLP00000018253	ENSAPLP00000018470	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.883
ATG5	MTOR	ENSAPLP00000018253	ENSAPLP00000007032	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.511
ATG5	ULK1	ENSAPLP00000018253	ENSAPLP00000014667	Autophagy protein 5; Involved in autophagic vesicle formation.	Unc-51 like autophagy activating kinase 1.	0.906