(18 nodes) (2022) The Role of Viral RNA Degrading Factors in Shutoff of Host Gene Expression. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LARP4	La ribonucleoprotein domain family member 4. (802 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	EIF4H	Eukaryotic translation initiation factor 4H. (251 aa)
	ANKRD17	ANK_REP_REGION domain-containing protein. (2097 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	NUDT21	Nudix hydrolase 21. (272 aa)
	NCL	Uncharacterized protein. (700 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	NUP93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (874 aa)
	CGAS	Cyclic GMP-AMP synthase. (545 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (350 aa)
	RNASEL	Uncharacterized protein. (772 aa)
	STAT4	Signal transducer and activator of transcription. (757 aa)
	IL6	Uncharacterized protein. (350 aa)
	RPL23A	Uncharacterized protein; Belongs to the universal ribosomal protein uL23 family. (70 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (391 aa)
	XRN1	5'-3' exoribonuclease 1. (1152 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGAS	STAT1	ENSAPLP00000018895	ENSAPLP00000013135	Cyclic GMP-AMP synthase.	Signal transducer and activator of transcription.	0.440
CGAS	TLR3	ENSAPLP00000018895	ENSAPLP00000008663	Cyclic GMP-AMP synthase.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.515
IL6	RNASEL	ENSAPLP00000020478	ENSAPLP00000029801	Uncharacterized protein.	Uncharacterized protein.	0.418
IL6	STAT1	ENSAPLP00000020478	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.873
IL6	STAT3	ENSAPLP00000020478	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.969
IL6	STAT4	ENSAPLP00000020478	ENSAPLP00000024437	Uncharacterized protein.	Signal transducer and activator of transcription.	0.771
IL6	TLR2	ENSAPLP00000020478	ENSAPLP00000011131	Uncharacterized protein.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.667
IL6	TLR3	ENSAPLP00000020478	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.869
NCL	RPL23A	ENSAPLP00000012724	ENSAPLP00000000159	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL23 family.	0.429
RNASEL	IL6	ENSAPLP00000029801	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.418
RNASEL	STAT1	ENSAPLP00000029801	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.757
RNASEL	STAT3	ENSAPLP00000029801	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.464
RNASEL	STAT4	ENSAPLP00000029801	ENSAPLP00000024437	Uncharacterized protein.	Signal transducer and activator of transcription.	0.456
RNASEL	TLR3	ENSAPLP00000029801	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.718
RPL23A	NCL	ENSAPLP00000000159	ENSAPLP00000012724	Uncharacterized protein; Belongs to the universal ribosomal protein uL23 family.	Uncharacterized protein.	0.429
RPL23A	XRN1	ENSAPLP00000000159	ENSAPLP00000004481	Uncharacterized protein; Belongs to the universal ribosomal protein uL23 family.	5'-3' exoribonuclease 1.	0.531
STAT1	CGAS	ENSAPLP00000013135	ENSAPLP00000018895	Signal transducer and activator of transcription.	Cyclic GMP-AMP synthase.	0.440
STAT1	IL6	ENSAPLP00000013135	ENSAPLP00000020478	Signal transducer and activator of transcription.	Uncharacterized protein.	0.873
STAT1	RNASEL	ENSAPLP00000013135	ENSAPLP00000029801	Signal transducer and activator of transcription.	Uncharacterized protein.	0.757
STAT1	STAT3	ENSAPLP00000013135	ENSAPLP00000007496	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.961