(20 nodes) (2022) Recent Drug Development in the Woodchuck Model of Chronic Hepatitis B. network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EGFR	Receptor protein-tyrosine kinase. (1219 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	GOT1	Aspartate aminotransferase. (403 aa)
	IL6	Uncharacterized protein. (350 aa)
	CGAS	Cyclic GMP-AMP synthase. (545 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (721 aa)
	IL10	Interleukin 10. (177 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	TLR4	Toll like receptor 4. (843 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (423 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
	GOT2	Aspartate aminotransferase. (440 aa)
	IL18	Interleukin-18. (197 aa)
	SORD	Sorbitol dehydrogenase. (344 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	PDCD1	Ig-like domain-containing protein. (396 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (185 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CTLA4	ENSAPLP00000018005	ENSAPLP00000001417	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte associated protein 4.	0.946
CD4	ENSAPLP00000028410	ENSAPLP00000018005	ENSAPLP00000028410	Ig-like domain-containing protein.	Uncharacterized protein.	0.632
CD4	GOT1	ENSAPLP00000018005	ENSAPLP00000021568	Ig-like domain-containing protein.	Aspartate aminotransferase.	0.416
CD4	GOT2	ENSAPLP00000018005	ENSAPLP00000006507	Ig-like domain-containing protein.	Aspartate aminotransferase.	0.412
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL10	ENSAPLP00000018005	ENSAPLP00000015242	Ig-like domain-containing protein.	Interleukin 10.	0.959
CD4	IL18	ENSAPLP00000018005	ENSAPLP00000005562	Ig-like domain-containing protein.	Interleukin-18.	0.648
CD4	IL21	ENSAPLP00000018005	ENSAPLP00000006533	Ig-like domain-containing protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.764
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	IRF7	ENSAPLP00000018005	ENSAPLP00000026565	Ig-like domain-containing protein.	Interferon regulatory factor 7.	0.418
CD4	MX1	ENSAPLP00000018005	ENSAPLP00000015901	Ig-like domain-containing protein.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.437
CD4	PDCD1	ENSAPLP00000018005	ENSAPLP00000003076	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.844
CD4	TLR2	ENSAPLP00000018005	ENSAPLP00000011131	Ig-like domain-containing protein.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.577
CD4	TLR4	ENSAPLP00000018005	ENSAPLP00000012401	Ig-like domain-containing protein.	Toll like receptor 4.	0.837
CD4	TLR7	ENSAPLP00000018005	ENSAPLP00000003630	Ig-like domain-containing protein.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.873
CGAS	ENSAPLP00000028410	ENSAPLP00000018895	ENSAPLP00000028410	Cyclic GMP-AMP synthase.	Uncharacterized protein.	0.507
CGAS	IRF7	ENSAPLP00000018895	ENSAPLP00000026565	Cyclic GMP-AMP synthase.	Interferon regulatory factor 7.	0.504
CGAS	TLR7	ENSAPLP00000018895	ENSAPLP00000003630	Cyclic GMP-AMP synthase.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.465
CTLA4	CD4	ENSAPLP00000001417	ENSAPLP00000018005	Cytotoxic T-lymphocyte associated protein 4.	Ig-like domain-containing protein.	0.946
CTLA4	IFNG	ENSAPLP00000001417	ENSAPLP00000012661	Cytotoxic T-lymphocyte associated protein 4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.751