STRINGSTRING
ATG7 ATG7 SOCS1 SOCS1 MAVS MAVS SYK SYK TLR7 TLR7 MAPK12 MAPK12 RSAD2 RSAD2 TLR3 TLR3 IFNAR1 IFNAR1 JAK1 JAK1 STAT1 STAT1 IL6 IL6 IRF7 IRF7 CDK9 CDK9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (735 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
MAVSCARD_2 domain-containing protein. (619 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (345 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (584 aa)
JAK1Tyrosine-protein kinase. (1152 aa)
STAT1Signal transducer and activator of transcription. (869 aa)
IL6Uncharacterized protein. (350 aa)
IRF7Interferon regulatory factor 7. (523 aa)
CDK9Cyclin dependent kinase 9. (403 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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