(13 nodes) (2023) Determining the Protective Efficacy of Toll-Like Receptor Ligands to Minimize H9N2 Avian Influenza Virus Transmission in Chickens. network (Anas platyrhynchos)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	IL18	Interleukin-18. (197 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	TLR-15	TIR domain-containing protein. (863 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TLR4	Toll like receptor 4. (843 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	IL6	Uncharacterized protein. (350 aa)
	IL-17	Uncharacterized protein. (191 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (878 aa)
	MAVS	CARD_2 domain-containing protein. (619 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	ENSAPLP00000028410	ENSAPLP00000018005	ENSAPLP00000028410	Ig-like domain-containing protein.	Uncharacterized protein.	0.632
CD4	IFNG	ENSAPLP00000018005	ENSAPLP00000012661	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.958
CD4	IL-17	ENSAPLP00000018005	ENSAPLP00000026822	Ig-like domain-containing protein.	Uncharacterized protein.	0.959
CD4	IL18	ENSAPLP00000018005	ENSAPLP00000005562	Ig-like domain-containing protein.	Interleukin-18.	0.648
CD4	IL6	ENSAPLP00000018005	ENSAPLP00000020478	Ig-like domain-containing protein.	Uncharacterized protein.	0.961
CD4	TLR2	ENSAPLP00000018005	ENSAPLP00000011131	Ig-like domain-containing protein.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.577
CD4	TLR3	ENSAPLP00000018005	ENSAPLP00000008663	Ig-like domain-containing protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.811
CD4	TLR4	ENSAPLP00000018005	ENSAPLP00000012401	Ig-like domain-containing protein.	Toll like receptor 4.	0.837
CD4	TLR5	ENSAPLP00000018005	ENSAPLP00000000694	Ig-like domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.727
CD4	TLR7	ENSAPLP00000018005	ENSAPLP00000003630	Ig-like domain-containing protein.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.873
ENSAPLP00000028410	CD4	ENSAPLP00000028410	ENSAPLP00000018005	Uncharacterized protein.	Ig-like domain-containing protein.	0.632
ENSAPLP00000028410	IFNG	ENSAPLP00000028410	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.970
ENSAPLP00000028410	IL-17	ENSAPLP00000028410	ENSAPLP00000026822	Uncharacterized protein.	Uncharacterized protein.	0.450
ENSAPLP00000028410	IL18	ENSAPLP00000028410	ENSAPLP00000005562	Uncharacterized protein.	Interleukin-18.	0.517
ENSAPLP00000028410	IL6	ENSAPLP00000028410	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSAPLP00000028410	MAVS	ENSAPLP00000028410	ENSAPLP00000002790	Uncharacterized protein.	CARD_2 domain-containing protein.	0.632
ENSAPLP00000028410	TLR3	ENSAPLP00000028410	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.795
ENSAPLP00000028410	TLR4	ENSAPLP00000028410	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.519
ENSAPLP00000028410	TLR7	ENSAPLP00000028410	ENSAPLP00000003630	Uncharacterized protein.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.698
IFNG	CD4	ENSAPLP00000012661	ENSAPLP00000018005	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Ig-like domain-containing protein.	0.958