(23 nodes) (2023) Current Knowledge of the Molecular Pathogenesis of Cutaneous Lupus Erythematosus. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PITX1	Homeobox protein. (302 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	ENSAPLP00000027915	Peptidase S1 domain-containing protein. (59 aa)
	IL-17	Uncharacterized protein. (191 aa)
	STAT4	Signal transducer and activator of transcription. (757 aa)
	STING1	Transmembrane protein 173. (420 aa)
	IL6	Uncharacterized protein. (350 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (287 aa)
	C1QA	Complement C1q A chain. (243 aa)
	EXO1	Exonuclease 1. (808 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (573 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	JAK1	Tyrosine-protein kinase. (1152 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	VGLL3	Vestigial like family member 3. (326 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	IRF5	IRF-3 domain-containing protein. (174 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (827 aa)
	C1S	Complement C1s; Belongs to the peptidase S1 family. (690 aa)
	U3I913_ANAPP	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (312 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (185 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1QA	C1R	ENSAPLP00000017046	ENSAPLP00000005746	Complement C1q A chain.	Complement C1r; Belongs to the peptidase S1 family.	0.489
C1QA	C1S	ENSAPLP00000017046	ENSAPLP00000005129	Complement C1q A chain.	Complement C1s; Belongs to the peptidase S1 family.	0.520
C1R	C1QA	ENSAPLP00000005746	ENSAPLP00000017046	Complement C1r; Belongs to the peptidase S1 family.	Complement C1q A chain.	0.489
C1R	C1S	ENSAPLP00000005746	ENSAPLP00000005129	Complement C1r; Belongs to the peptidase S1 family.	Complement C1s; Belongs to the peptidase S1 family.	0.998
C1S	C1QA	ENSAPLP00000005129	ENSAPLP00000017046	Complement C1s; Belongs to the peptidase S1 family.	Complement C1q A chain.	0.520
C1S	C1R	ENSAPLP00000005129	ENSAPLP00000005746	Complement C1s; Belongs to the peptidase S1 family.	Complement C1r; Belongs to the peptidase S1 family.	0.998
CTLA4	ENSAPLP00000027915	ENSAPLP00000001417	ENSAPLP00000027915	Cytotoxic T-lymphocyte associated protein 4.	Peptidase S1 domain-containing protein.	0.550
CTLA4	IFNG	ENSAPLP00000001417	ENSAPLP00000012661	Cytotoxic T-lymphocyte associated protein 4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.751
CTLA4	IL-17	ENSAPLP00000001417	ENSAPLP00000026822	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.675
CTLA4	IL6	ENSAPLP00000001417	ENSAPLP00000020478	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.647
CTLA4	STAT3	ENSAPLP00000001417	ENSAPLP00000007496	Cytotoxic T-lymphocyte associated protein 4.	Signal transducer and activator of transcription.	0.464
ENSAPLP00000027915	CTLA4	ENSAPLP00000027915	ENSAPLP00000001417	Peptidase S1 domain-containing protein.	Cytotoxic T-lymphocyte associated protein 4.	0.550
ENSAPLP00000027915	IFNG	ENSAPLP00000027915	ENSAPLP00000012661	Peptidase S1 domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.564
ENSAPLP00000028410	IFNG	ENSAPLP00000028410	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.970
ENSAPLP00000028410	IL-17	ENSAPLP00000028410	ENSAPLP00000026822	Uncharacterized protein.	Uncharacterized protein.	0.450
ENSAPLP00000028410	IL6	ENSAPLP00000028410	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSAPLP00000028410	IRF5	ENSAPLP00000028410	ENSAPLP00000005791	Uncharacterized protein.	IRF-3 domain-containing protein.	0.463
ENSAPLP00000028410	JAK1	ENSAPLP00000028410	ENSAPLP00000011906	Uncharacterized protein.	Tyrosine-protein kinase.	0.473
ENSAPLP00000028410	STAT1	ENSAPLP00000028410	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.707
ENSAPLP00000028410	STAT3	ENSAPLP00000028410	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.468