(14 nodes) (2023) Infection and innate immune mechanism of goose astrovirus. network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MAVS	CARD_2 domain-containing protein. (619 aa)
	ADA	Adenosine deaminase. (359 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1420 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	IL10	Interleukin 10. (177 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (721 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1151 aa)
	IL6	Uncharacterized protein. (350 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	ENSAPLP00000027088	Serine protease; Belongs to the peptidase S1B family. (348 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	CD81	Tetraspanin. (467 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNG	IL10	ENSAPLP00000012661	ENSAPLP00000015242	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin 10.	0.974
IFNG	IL6	ENSAPLP00000012661	ENSAPLP00000020478	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.959
IFNG	IRF7	ENSAPLP00000012661	ENSAPLP00000026565	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interferon regulatory factor 7.	0.521
IFNG	MX1	ENSAPLP00000012661	ENSAPLP00000015901	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.554
IFNG	MYD88	ENSAPLP00000012661	ENSAPLP00000028214	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.702
IFNG	NOS2	ENSAPLP00000012661	ENSAPLP00000016156	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Nitric oxide synthase; Produces nitric oxide (NO).	0.611
IFNG	TLR3	ENSAPLP00000012661	ENSAPLP00000008663	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.680
IL10	IFNG	ENSAPLP00000015242	ENSAPLP00000012661	Interleukin 10.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.974
IL10	IL6	ENSAPLP00000015242	ENSAPLP00000020478	Interleukin 10.	Uncharacterized protein.	0.975
IL10	IRF7	ENSAPLP00000015242	ENSAPLP00000026565	Interleukin 10.	Interferon regulatory factor 7.	0.429
IL10	MX1	ENSAPLP00000015242	ENSAPLP00000015901	Interleukin 10.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.447
IL10	MYD88	ENSAPLP00000015242	ENSAPLP00000028214	Interleukin 10.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.784
IL10	NOS2	ENSAPLP00000015242	ENSAPLP00000016156	Interleukin 10.	Nitric oxide synthase; Produces nitric oxide (NO).	0.636
IL10	TLR3	ENSAPLP00000015242	ENSAPLP00000008663	Interleukin 10.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.785
IL6	IFNG	ENSAPLP00000020478	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.959
IL6	IL10	ENSAPLP00000020478	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.975
IL6	IRF7	ENSAPLP00000020478	ENSAPLP00000026565	Uncharacterized protein.	Interferon regulatory factor 7.	0.646
IL6	MAVS	ENSAPLP00000020478	ENSAPLP00000002790	Uncharacterized protein.	CARD_2 domain-containing protein.	0.432
IL6	MX1	ENSAPLP00000020478	ENSAPLP00000015901	Uncharacterized protein.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.681
IL6	MYD88	ENSAPLP00000020478	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.878