(12 nodes) (2023) Preclinical characterization of the Toll-like receptor 78 antagonist MHV370 for lupus therapy. network (Anas platyrhynchos)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	TLR4	Toll like receptor 4. (843 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (914 aa)
	RO60	Ro60, Y RNA binding protein. (538 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (878 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (951 aa)
	IL6	Uncharacterized protein. (350 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000028410	IL6	ENSAPLP00000028410	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSAPLP00000028410	IRF7	ENSAPLP00000028410	ENSAPLP00000026565	Uncharacterized protein.	Interferon regulatory factor 7.	0.961
ENSAPLP00000028410	MYD88	ENSAPLP00000028410	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.498
ENSAPLP00000028410	TLR3	ENSAPLP00000028410	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.795
ENSAPLP00000028410	TLR4	ENSAPLP00000028410	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.519
IL6	ENSAPLP00000028410	ENSAPLP00000020478	ENSAPLP00000028410	Uncharacterized protein.	Uncharacterized protein.	0.807
IL6	INS	ENSAPLP00000020478	ENSAPLP00000012854	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.770
IL6	IRF7	ENSAPLP00000020478	ENSAPLP00000026565	Uncharacterized protein.	Interferon regulatory factor 7.	0.646
IL6	MYD88	ENSAPLP00000020478	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.878
IL6	NOD1	ENSAPLP00000020478	ENSAPLP00000023952	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 1.	0.511
IL6	TLR2	ENSAPLP00000020478	ENSAPLP00000011131	Uncharacterized protein.	Toll like receptor 2; Belongs to the Toll-like receptor family.	0.667
IL6	TLR3	ENSAPLP00000020478	ENSAPLP00000008663	Uncharacterized protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.869
IL6	TLR4	ENSAPLP00000020478	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.957
IL6	TLR5	ENSAPLP00000020478	ENSAPLP00000000694	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.748
IL6	TRAF6	ENSAPLP00000020478	ENSAPLP00000027926	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.753
INS	IL6	ENSAPLP00000012854	ENSAPLP00000020478	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.770
INS	TLR4	ENSAPLP00000012854	ENSAPLP00000012401	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Toll like receptor 4.	0.589
IRF7	ENSAPLP00000028410	ENSAPLP00000026565	ENSAPLP00000028410	Interferon regulatory factor 7.	Uncharacterized protein.	0.961
IRF7	IL6	ENSAPLP00000026565	ENSAPLP00000020478	Interferon regulatory factor 7.	Uncharacterized protein.	0.646
IRF7	MYD88	ENSAPLP00000026565	ENSAPLP00000028214	Interferon regulatory factor 7.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.944