(43 nodes) (2023) Dysregulated MicroRNAs in the Pathogenesis of Systemic Lupus Erythematosus: A Comprehensive Review. network (Anas platyrhynchos)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAPLP00000030066	IRF-3 domain-containing protein. (225 aa)
	BDH2	3-hydroxybutyrate dehydrogenase 2. (245 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1397 aa)
	CALML4	Calmodulin like 4. (195 aa)
	PDCD4	Programmed cell death 4. (467 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	U3I8R2_ANAPP	Uncharacterized protein. (1687 aa)
	DGCR8	DGCR8 microprocessor complex subunit. (775 aa)
	KLF5	Kruppel like factor 5. (446 aa)
	LYN	Tyrosine-protein kinase. (535 aa)
	RASGRP1	RAS guanyl releasing protein 1. (857 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (301 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	API5	Apoptosis inhibitor 5. (513 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1280 aa)
	IL7	Uncharacterized protein. (144 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1225 aa)
	IRF8	IRF-3 domain-containing protein. (306 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	IL4	Uncharacterized protein. (136 aa)
	EZR	Ezrin. (585 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	LCK	Tyrosine-protein kinase. (507 aa)
	RHOA	Ras homolog family member A. (193 aa)
	IL10	Interleukin 10. (177 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	CD44	CD44 molecule (Indian blood group). (645 aa)
	CD4	Ig-like domain-containing protein. (264 aa)
	BCL6	Uncharacterized protein. (709 aa)
	RDX	Radixin. (604 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	IL6	Uncharacterized protein. (350 aa)
	MSN	Moesin. (615 aa)
	IL-17	Uncharacterized protein. (191 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	XPO5	Exportin 5. (1004 aa)
	IRF4	Interferon regulatory factor 4. (446 aa)
	CREM	cAMP responsive element modulator. (368 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CD4	ENSAPLP00000018321	ENSAPLP00000018005	Uncharacterized protein.	Ig-like domain-containing protein.	0.752
BCL6	CD44	ENSAPLP00000018321	ENSAPLP00000016839	Uncharacterized protein.	CD44 molecule (Indian blood group).	0.644
BCL6	ENSAPLP00000030066	ENSAPLP00000018321	ENSAPLP00000030066	Uncharacterized protein.	IRF-3 domain-containing protein.	0.460
BCL6	IFNG	ENSAPLP00000018321	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.504
BCL6	IL-17	ENSAPLP00000018321	ENSAPLP00000026822	Uncharacterized protein.	Uncharacterized protein.	0.541
BCL6	IL10	ENSAPLP00000018321	ENSAPLP00000015242	Uncharacterized protein.	Interleukin 10.	0.429
BCL6	IL4	ENSAPLP00000018321	ENSAPLP00000011598	Uncharacterized protein.	Uncharacterized protein.	0.766
BCL6	IL6	ENSAPLP00000018321	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.509
BCL6	IRF4	ENSAPLP00000018321	ENSAPLP00000030637	Uncharacterized protein.	Interferon regulatory factor 4.	0.638
BCL6	STAT3	ENSAPLP00000018321	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.545
BCL6	TLR7	ENSAPLP00000018321	ENSAPLP00000003630	Uncharacterized protein.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.482
BCR	RHOA	ENSAPLP00000008835	ENSAPLP00000014536	BCR activator of RhoGEF and GTPase.	Ras homolog family member A.	0.468
CALM1	CALML3	ENSAPLP00000020112	ENSAPLP00000006875	Calmodulin 1; Belongs to the calmodulin family.	Calmodulin like 3; Belongs to the calmodulin family.	0.911
CALM1	CALML4	ENSAPLP00000020112	ENSAPLP00000002547	Calmodulin 1; Belongs to the calmodulin family.	Calmodulin like 4.	0.914
CALML3	CALM1	ENSAPLP00000006875	ENSAPLP00000020112	Calmodulin like 3; Belongs to the calmodulin family.	Calmodulin 1; Belongs to the calmodulin family.	0.911
CALML3	CALML4	ENSAPLP00000006875	ENSAPLP00000002547	Calmodulin like 3; Belongs to the calmodulin family.	Calmodulin like 4.	0.905
CALML3	RDX	ENSAPLP00000006875	ENSAPLP00000018411	Calmodulin like 3; Belongs to the calmodulin family.	Radixin.	0.498
CALML3	RHOA	ENSAPLP00000006875	ENSAPLP00000014536	Calmodulin like 3; Belongs to the calmodulin family.	Ras homolog family member A.	0.460
CALML4	CALM1	ENSAPLP00000002547	ENSAPLP00000020112	Calmodulin like 4.	Calmodulin 1; Belongs to the calmodulin family.	0.914
CALML4	CALML3	ENSAPLP00000002547	ENSAPLP00000006875	Calmodulin like 4.	Calmodulin like 3; Belongs to the calmodulin family.	0.905