(12 nodes) (2023) System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and Pathogenesis. network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
	TKT	Transketolase. (582 aa)
	SERPINC1	Serpin family C member 1; Belongs to the serpin family. (563 aa)
	BMP6	Bone morphogenetic protein 6. (453 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	TLR4	Toll like receptor 4. (843 aa)
	JAK1	Tyrosine-protein kinase. (1152 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (584 aa)
	STAT3	Signal transducer and activator of transcription. (942 aa)
	IL6	Uncharacterized protein. (350 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	IL6	ENSAPLP00000019939	ENSAPLP00000020478	BCL2 apoptosis regulator.	Uncharacterized protein.	0.782
BCL2	STAT1	ENSAPLP00000019939	ENSAPLP00000013135	BCL2 apoptosis regulator.	Signal transducer and activator of transcription.	0.637
BCL2	STAT3	ENSAPLP00000019939	ENSAPLP00000007496	BCL2 apoptosis regulator.	Signal transducer and activator of transcription.	0.830
BCL2	TLR4	ENSAPLP00000019939	ENSAPLP00000012401	BCL2 apoptosis regulator.	Toll like receptor 4.	0.606
IFNAR1	IL6	ENSAPLP00000011065	ENSAPLP00000020478	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.490
IFNAR1	JAK1	ENSAPLP00000011065	ENSAPLP00000011906	Interferon alpha and beta receptor subunit 1.	Tyrosine-protein kinase.	0.994
IFNAR1	JAK2	ENSAPLP00000011065	ENSAPLP00000027035	Interferon alpha and beta receptor subunit 1.	Tyrosine-protein kinase.	0.959
IFNAR1	STAT1	ENSAPLP00000011065	ENSAPLP00000013135	Interferon alpha and beta receptor subunit 1.	Signal transducer and activator of transcription.	0.992
IFNAR1	STAT3	ENSAPLP00000011065	ENSAPLP00000007496	Interferon alpha and beta receptor subunit 1.	Signal transducer and activator of transcription.	0.792
IFNAR1	TLR4	ENSAPLP00000011065	ENSAPLP00000012401	Interferon alpha and beta receptor subunit 1.	Toll like receptor 4.	0.402
IL6	BCL2	ENSAPLP00000020478	ENSAPLP00000019939	Uncharacterized protein.	BCL2 apoptosis regulator.	0.782
IL6	IFNAR1	ENSAPLP00000020478	ENSAPLP00000011065	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.490
IL6	JAK1	ENSAPLP00000020478	ENSAPLP00000011906	Uncharacterized protein.	Tyrosine-protein kinase.	0.839
IL6	JAK2	ENSAPLP00000020478	ENSAPLP00000027035	Uncharacterized protein.	Tyrosine-protein kinase.	0.749
IL6	STAT1	ENSAPLP00000020478	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.873
IL6	STAT3	ENSAPLP00000020478	ENSAPLP00000007496	Uncharacterized protein.	Signal transducer and activator of transcription.	0.969
IL6	TLR4	ENSAPLP00000020478	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.957
JAK1	IFNAR1	ENSAPLP00000011906	ENSAPLP00000011065	Tyrosine-protein kinase.	Interferon alpha and beta receptor subunit 1.	0.994
JAK1	IL6	ENSAPLP00000011906	ENSAPLP00000020478	Tyrosine-protein kinase.	Uncharacterized protein.	0.839
JAK1	JAK2	ENSAPLP00000011906	ENSAPLP00000027035	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.955