(57 nodes) Inositol phosphate metabolism network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTM1	Myotubularin 1. (607 aa)
	PI4KB	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (851 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2123 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	MTMR8	Myotubularin related protein 8. (629 aa)
	PIP4K2B	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (357 aa)
	MTMR2	Myotubularin related protein 2. (645 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (365 aa)
	IPPK	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (163 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (581 aa)
	IMPA1	Inositol-1-monophosphatase. (278 aa)
	MTMR14	Myotubularin related protein 14. (523 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	INPP5E	Inositol polyphosphate-5-phosphatase E. (639 aa)
	PLCG1	Phosphoinositide phospholipase C. (502 aa)
	PLCD1	Phosphoinositide phospholipase C. (779 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	U3IN59_ANAPP	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1295 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1476 aa)
	PLCG2	Phosphoinositide phospholipase C. (1086 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1700 aa)
	IPMK	Kinase; Belongs to the inositol phosphokinase (IPK) family. (380 aa)
	MTMR6	Myotubularin related protein 6. (580 aa)
	INPP5J	IPPc domain-containing protein. (353 aa)
	ITPKA	Kinase; Belongs to the inositol phosphokinase (IPK) family. (465 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	MTMR4	Myotubularin related protein 4. (1141 aa)
	FIG4	FIG4 phosphoinositide 5-phosphatase. (908 aa)
	PLCE1	Phosphoinositide phospholipase C. (1847 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (609 aa)
	OCRL	IPPc domain-containing protein. (692 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2091 aa)
	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (636 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (864 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	PIP5K1B	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (556 aa)
	IMPA2	Inositol-1-monophosphatase. (374 aa)
	MTMR3	Myotubularin related protein 3. (1218 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (681 aa)
	INPP5F	SAC domain-containing protein. (246 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (421 aa)
	INPP4A	Inositol polyphosphate-4-phosphatase type I A. (981 aa)
	INPP5D	SH2 domain-containing protein. (1260 aa)
	ISYNA1	Uncharacterized protein. (146 aa)
	MTMR1	Uncharacterized protein. (260 aa)
	PLCZ1	Phosphoinositide phospholipase C. (646 aa)
	SACM1L	SAC1 like phosphatidylinositide phosphatase. (490 aa)
	PLCH1	Phosphoinositide phospholipase C. (1704 aa)
	ENSAPLP00000029349	PLCXc domain-containing protein. (341 aa)
	MTMR7	Myotubularin related protein 7. (695 aa)
	INPP4B	Inositol polyphosphate-4-phosphatase type II B. (1090 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (257 aa)
	MINPP1	Multiple inositol-polyphosphate phosphatase 1; Belongs to the histidine acid phosphatase family. (421 aa)
	SYNJ2	Synaptojanin 2. (1521 aa)
	PLCH2	Phosphoinositide phospholipase C. (1581 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000029349	IMPA1	ENSAPLP00000029349	ENSAPLP00000005372	PLCXc domain-containing protein.	Inositol-1-monophosphatase.	0.900
ENSAPLP00000029349	IMPA2	ENSAPLP00000029349	ENSAPLP00000017163	PLCXc domain-containing protein.	Inositol-1-monophosphatase.	0.900
ENSAPLP00000029349	INPP5F	ENSAPLP00000029349	ENSAPLP00000020788	PLCXc domain-containing protein.	SAC domain-containing protein.	0.900
ENSAPLP00000029349	MTM1	ENSAPLP00000029349	ENSAPLP00000001870	PLCXc domain-containing protein.	Myotubularin 1.	0.900
ENSAPLP00000029349	MTMR1	ENSAPLP00000029349	ENSAPLP00000026504	PLCXc domain-containing protein.	Uncharacterized protein.	0.900
ENSAPLP00000029349	MTMR14	ENSAPLP00000029349	ENSAPLP00000006050	PLCXc domain-containing protein.	Myotubularin related protein 14.	0.900
ENSAPLP00000029349	MTMR2	ENSAPLP00000029349	ENSAPLP00000003625	PLCXc domain-containing protein.	Myotubularin related protein 2.	0.900
ENSAPLP00000029349	MTMR3	ENSAPLP00000029349	ENSAPLP00000017906	PLCXc domain-containing protein.	Myotubularin related protein 3.	0.900
ENSAPLP00000029349	MTMR4	ENSAPLP00000029349	ENSAPLP00000012805	PLCXc domain-containing protein.	Myotubularin related protein 4.	0.900
ENSAPLP00000029349	MTMR6	ENSAPLP00000029349	ENSAPLP00000011358	PLCXc domain-containing protein.	Myotubularin related protein 6.	0.900
ENSAPLP00000029349	MTMR7	ENSAPLP00000029349	ENSAPLP00000029442	PLCXc domain-containing protein.	Myotubularin related protein 7.	0.900
ENSAPLP00000029349	MTMR8	ENSAPLP00000029349	ENSAPLP00000003396	PLCXc domain-containing protein.	Myotubularin related protein 8.	0.900
ENSAPLP00000029349	PI4KA	ENSAPLP00000029349	ENSAPLP00000002665	PLCXc domain-containing protein.	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.900
ENSAPLP00000029349	PI4KB	ENSAPLP00000029349	ENSAPLP00000001897	PLCXc domain-containing protein.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.900
ENSAPLP00000029349	PIK3C3	ENSAPLP00000029349	ENSAPLP00000012571	PLCXc domain-containing protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.900
ENSAPLP00000029349	SACM1L	ENSAPLP00000029349	ENSAPLP00000028685	PLCXc domain-containing protein.	SAC1 like phosphatidylinositide phosphatase.	0.900
FIG4	INPP4A	ENSAPLP00000013114	ENSAPLP00000022456	FIG4 phosphoinositide 5-phosphatase.	Inositol polyphosphate-4-phosphatase type I A.	0.906
FIG4	INPP4B	ENSAPLP00000013114	ENSAPLP00000029717	FIG4 phosphoinositide 5-phosphatase.	Inositol polyphosphate-4-phosphatase type II B.	0.906
FIG4	MTM1	ENSAPLP00000013114	ENSAPLP00000001870	FIG4 phosphoinositide 5-phosphatase.	Myotubularin 1.	0.927
FIG4	MTMR1	ENSAPLP00000013114	ENSAPLP00000026504	FIG4 phosphoinositide 5-phosphatase.	Uncharacterized protein.	0.955