(62 nodes) ErbB signaling pathway network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EGFR	Receptor protein-tyrosine kinase. (1219 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	PAK6	Non-specific serine/threonine protein kinase. (693 aa)
	SHC4	SHC adaptor protein 4. (631 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (301 aa)
	U3IGX0_ANAPP	Uncharacterized protein. (463 aa)
	PLCG1	Phosphoinositide phospholipase C. (502 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	CRK	CRK proto-oncogene, adaptor protein. (306 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	SHC1	SHC adaptor protein 1. (616 aa)
	U3IN59_ANAPP	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1295 aa)
	NRAS	Uncharacterized protein. (189 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1323 aa)
	PLCG2	Phosphoinositide phospholipase C. (1086 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PIK3R2	Uncharacterized protein. (731 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1182 aa)
	CBLB	Cbl proto-oncogene B. (971 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	EREG	Epiregulin. (148 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (409 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CBL	Cbl proto-oncogene. (814 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
	PAK5	CRIB domain-containing protein. (344 aa)
	HBEGF	Heparin binding EGF like growth factor. (378 aa)
	PAK2	CRIB domain-containing protein. (161 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (100 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	SHC2	Uncharacterized protein. (781 aa)
	PAK4	P21 (RAC1) activated kinase 4. (639 aa)
	NRG1	Neuregulin 1. (685 aa)
	PTK2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	PRKCA	Protein kinase C. (649 aa)
	PAK1	CRIB domain-containing protein. (170 aa)
	ABL2	Tyrosine-protein kinase. (1135 aa)
	NRG3	Neuregulin 3. (346 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
	ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase. (610 aa)
	AREG	Amphiregulin. (212 aa)
	PAK3	Non-specific serine/threonine protein kinase. (562 aa)
	ENSAPLP00000024738	Uncharacterized protein. (257 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	BTC	EGF-like domain-containing protein. (417 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (362 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1317 aa)
	NRG4	Neuregulin 4. (115 aa)
	GRB2	Growth factor receptor bound protein 2. (203 aa)
	CDKN1A-2	Uncharacterized protein. (182 aa)
	CAMK2D	Protein kinase domain-containing protein. (355 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSAPLP00000022843	ENSAPLP00000020556	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Tyrosine-protein kinase.	0.900
ABL1	CBL	ENSAPLP00000022843	ENSAPLP00000013414	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Cbl proto-oncogene.	0.447
ABL1	CBLB	ENSAPLP00000022843	ENSAPLP00000011670	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Cbl proto-oncogene B.	0.447
ABL1	CRK	ENSAPLP00000022843	ENSAPLP00000007163	ABL proto-oncogene 1, non-receptor tyrosine kinase.	CRK proto-oncogene, adaptor protein.	0.964
ABL1	CRKL	ENSAPLP00000022843	ENSAPLP00000006274	ABL proto-oncogene 1, non-receptor tyrosine kinase.	CRK like proto-oncogene, adaptor protein.	0.951
ABL1	GRB2	ENSAPLP00000022843	ENSAPLP00000031733	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Growth factor receptor bound protein 2.	0.509
ABL1	MAPK1	ENSAPLP00000022843	ENSAPLP00000005723	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.407
ABL2	ABL1	ENSAPLP00000020556	ENSAPLP00000022843	Tyrosine-protein kinase.	ABL proto-oncogene 1, non-receptor tyrosine kinase.	0.900
ABL2	CBL	ENSAPLP00000020556	ENSAPLP00000013414	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.447
ABL2	CBLB	ENSAPLP00000020556	ENSAPLP00000011670	Tyrosine-protein kinase.	Cbl proto-oncogene B.	0.447
ABL2	CRK	ENSAPLP00000020556	ENSAPLP00000007163	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.964
ABL2	CRKL	ENSAPLP00000020556	ENSAPLP00000006274	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.951
ABL2	GRB2	ENSAPLP00000020556	ENSAPLP00000031733	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.509
ABL2	MAPK1	ENSAPLP00000020556	ENSAPLP00000005723	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.407
AKT1	AKT3	ENSAPLP00000016229	ENSAPLP00000011266	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CDKN1A-2	ENSAPLP00000016229	ENSAPLP00000031755	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944
AKT1	CDKN1B	ENSAPLP00000016229	ENSAPLP00000028790	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.959
AKT1	GSK3B	ENSAPLP00000016229	ENSAPLP00000026002	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.956
AKT1	MAP2K4	ENSAPLP00000016229	ENSAPLP00000012899	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.917
AKT1	MAPK1	ENSAPLP00000016229	ENSAPLP00000005723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925