STRINGSTRING
IRS4 IRS4 RBL2 RBL2 S1PR4 S1PR4 MAPK13 MAPK13 NLK NLK PCK1 PCK1 CCND2 CCND2 EGFR EGFR PIK3CB PIK3CB FOXO1 FOXO1 MAPK12 MAPK12 MAPK11 MAPK11 PRKAG2 PRKAG2 HOMER2 HOMER2 SOD2 SOD2 PLK2 PLK2 MAPK10 MAPK10 BNIP3 BNIP3 MAPK1 MAPK1 U3IGX0_ANAPP U3IGX0_ANAPP STK11 STK11 SETD7 SETD7 SMAD3 SMAD3 PRKAA2 PRKAA2 STAT3 STAT3 HOMER1 HOMER1 HOMER3 HOMER3 PIK3CD PIK3CD IGF1R IGF1R U3INX3_ANAPP U3INX3_ANAPP PLK4 PLK4 NRAS NRAS PRKAB1 PRKAB1 KLF2 KLF2 TGFBR1 TGFBR1 SOS1 SOS1 EP300 EP300 PLK1 PLK1 IGF1 IGF1 G6PC2 G6PC2 CCNG2 CCNG2 MDM2 MDM2 FOXO3 FOXO3 AKT3 AKT3 TGFB2 TGFB2 RAG1 RAG1 RAG2 RAG2 PIK3R2 PIK3R2 BCL2L11 BCL2L11 EGF EGF CCNB2 CCNB2 TGFB3 TGFB3 HRAS HRAS FBXO25 FBXO25 PRKAA1 PRKAA1 ATM ATM PIK3CA PIK3CA INS INS MAPK9 MAPK9 RAF1 RAF1 FOXO4 FOXO4 U3J4W3_ANAPP U3J4W3_ANAPP SGK3 SGK3 IL10 IL10 MAP2K1 MAP2K1 PTEN PTEN PDPK1 PDPK1 KRAS KRAS PRKAB2 PRKAB2 AKT1 AKT1 TNFSF10 TNFSF10 GRM1 GRM1 SGK1 SGK1 SKP2 SKP2 PIK3R1 PIK3R1 BCL6 BCL6 MAPK8 MAPK8 TGFBR2 TGFBR2 CCND1 CCND1 CREBBP CREBBP IL6 IL6 USP7 USP7 IL7R IL7R SOS2 SOS2 GABARAPL2 GABARAPL2 INSR INSR ENSAPLP00000025322 ENSAPLP00000025322 FOXO6 FOXO6 CAT CAT CDKN1B CDKN1B IKBKB IKBKB FBXO32 FBXO32 ATG12 ATG12 SIRT1 SIRT1 GADD45G GADD45G G6PC G6PC GRB2 GRB2 CDKN1A-2 CDKN1A-2 GADD45B GADD45B FOXG1 FOXG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRS4Insulin receptor substrate 4. (1128 aa)
RBL2RB transcriptional corepressor like 2. (1176 aa)
S1PR4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (408 aa)
MAPK13Mitogen-activated protein kinase 13. (158 aa)
NLKMitogen-activated protein kinase. (435 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (344 aa)
EGFRReceptor protein-tyrosine kinase. (1219 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
FOXO1Forkhead box O1. (678 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
HOMER2Homer scaffold protein 2. (356 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
PLK2Serine/threonine-protein kinase PLK. (665 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
BNIP3BCL2 interacting protein 3. (188 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
U3IGX0_ANAPPUncharacterized protein. (463 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (440 aa)
SETD7SET domain containing 7, histone lysine methyltransferase. (332 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
STAT3Signal transducer and activator of transcription. (942 aa)
HOMER1Homer scaffold protein 1. (355 aa)
HOMER3WH1 domain-containing protein. (340 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
U3INX3_ANAPPTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PLK4Polo like kinase 4. (1013 aa)
NRASUncharacterized protein. (189 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (273 aa)
KLF2Uncharacterized protein. (380 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1323 aa)
EP300E1A binding protein p300. (2355 aa)
PLK1Serine/threonine-protein kinase PLK. (596 aa)
IGF1Insulin like growth factor 1. (153 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (340 aa)
MDM2Uncharacterized protein. (423 aa)
FOXO3Fork-head domain-containing protein. (665 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1041 aa)
RAG2Recombination activating 2. (542 aa)
PIK3R2Uncharacterized protein. (731 aa)
BCL2L11BCL2 like 11. (159 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1182 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (392 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FBXO25F-box protein 25. (369 aa)
PRKAA1Non-specific serine/threonine protein kinase. (539 aa)
ATMNon-specific serine/threonine protein kinase. (2967 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
FOXO4Forkhead box O4. (455 aa)
U3J4W3_ANAPPUncharacterized protein. (164 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
IL10Interleukin 10. (177 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TNFSF10TNF superfamily member 10; Belongs to the tumor necrosis factor family. (295 aa)
GRM1ANF_receptor domain-containing protein. (338 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
SKP2S-phase kinase associated protein 2. (671 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BCL6Uncharacterized protein. (709 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (575 aa)
CCND1Cyclin_C domain-containing protein. (153 aa)
CREBBPCREB binding protein. (2396 aa)
IL6Uncharacterized protein. (350 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1083 aa)
IL7RInterleukin 7 receptor. (528 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
INSRTyrosine-protein kinase receptor. (1353 aa)
ENSAPLP00000025322ANK_REP_REGION domain-containing protein. (136 aa)
FOXO6Forkhead box O6. (491 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (362 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (778 aa)
FBXO32F-box protein 32. (224 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (217 aa)
SIRT1Sirtuin 1. (777 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (238 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (358 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
CDKN1A-2Uncharacterized protein. (182 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (350 aa)
FOXG1Forkhead box G1. (458 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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