(41 nodes) Mitophagy - animal network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATF4	Activating transcription factor 4. (354 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1149 aa)
	USP15	Ubiquitin carboxyl-terminal hydrolase. (961 aa)
	TBC1D15	TBC1 domain family member 15. (667 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (770 aa)
	RHOT2	Ras homolog family member T2. (519 aa)
	PGAM5	PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (140 aa)
	BECN1	Uncharacterized protein. (452 aa)
	OPTN	Optineurin. (556 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	BNIP3	BCL2 interacting protein 3. (188 aa)
	PINK1	PTEN induced kinase 1. (603 aa)
	TBK1	TANK binding kinase 1. (600 aa)
	BCL2L13	BCL2 like 13. (524 aa)
	NRAS	Uncharacterized protein. (189 aa)
	ATG9A	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (851 aa)
	FOXO3	Fork-head domain-containing protein. (665 aa)
	FUNDC1	FUN14 domain containing 1. (170 aa)
	E2F1	E2F transcription factor 1. (388 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
	MFN1	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (743 aa)
	CALCOCO2	Uncharacterized protein. (484 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	RRAS2	RAS related 2. (203 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (315 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	CSNK2A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (386 aa)
	ENSAPLP00000023897	Uncharacterized protein. (208 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (117 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	TAX1BP1	Tax1 binding protein 1. (816 aa)
	BCL2L1	BCL2 like 1. (238 aa)
	PRKN	Parkin RBR E3 ubiquitin protein ligase. (520 aa)
	NBR1	NBR1 autophagy cargo receptor. (996 aa)
	SQSTM1	Uncharacterized protein. (77 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (244 aa)
	RAB7A	RAB7A, member RAS oncogene family. (214 aa)
	CSNK2A2	Casein kinase 2 alpha 2. (396 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	PINK1	ENSAPLP00000001196	ENSAPLP00000007324	Activating transcription factor 4.	PTEN induced kinase 1.	0.449
ATG5	ATG9A	ENSAPLP00000018253	ENSAPLP00000010719	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.776
ATG5	BCL2L1	ENSAPLP00000018253	ENSAPLP00000025626	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 like 1.	0.613
ATG5	BECN1	ENSAPLP00000018253	ENSAPLP00000004076	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.982
ATG5	BNIP3	ENSAPLP00000018253	ENSAPLP00000005538	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 interacting protein 3.	0.586
ATG5	FUNDC1	ENSAPLP00000018253	ENSAPLP00000011818	Autophagy protein 5; Involved in autophagic vesicle formation.	FUN14 domain containing 1.	0.633
ATG5	GABARAPL2	ENSAPLP00000018253	ENSAPLP00000023898	Autophagy protein 5; Involved in autophagic vesicle formation.	GABA type A receptor associated protein like 2.	0.985
ATG5	MFN1	ENSAPLP00000018253	ENSAPLP00000012358	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.733
ATG5	MFN2	ENSAPLP00000018253	ENSAPLP00000012292	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.733
ATG5	NBR1	ENSAPLP00000018253	ENSAPLP00000025901	Autophagy protein 5; Involved in autophagic vesicle formation.	NBR1 autophagy cargo receptor.	0.779
ATG5	PINK1	ENSAPLP00000018253	ENSAPLP00000007324	Autophagy protein 5; Involved in autophagic vesicle formation.	PTEN induced kinase 1.	0.671
ATG5	PRKN	ENSAPLP00000018253	ENSAPLP00000025876	Autophagy protein 5; Involved in autophagic vesicle formation.	Parkin RBR E3 ubiquitin protein ligase.	0.541
ATG5	SQSTM1	ENSAPLP00000018253	ENSAPLP00000028233	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.888
ATG9A	ATG5	ENSAPLP00000010719	ENSAPLP00000018253	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.776
ATG9A	BECN1	ENSAPLP00000010719	ENSAPLP00000004076	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Uncharacterized protein.	0.912
ATG9A	GABARAPL2	ENSAPLP00000010719	ENSAPLP00000023898	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	GABA type A receptor associated protein like 2.	0.509
ATG9A	NBR1	ENSAPLP00000010719	ENSAPLP00000025901	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	NBR1 autophagy cargo receptor.	0.635
ATG9A	SQSTM1	ENSAPLP00000010719	ENSAPLP00000028233	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Uncharacterized protein.	0.652
BCL2L1	ATG5	ENSAPLP00000025626	ENSAPLP00000018253	BCL2 like 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.613
BCL2L1	BECN1	ENSAPLP00000025626	ENSAPLP00000004076	BCL2 like 1.	Uncharacterized protein.	0.997