99 items (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRS4	Insulin receptor substrate 4. (1128 aa)
	TSC1	TSC complex subunit 1. (1158 aa)
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (770 aa)
	SNAP29	Synaptosome associated protein 29. (326 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1077 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1348 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	BECN1	Uncharacterized protein. (452 aa)
	ZFYVE1	Zinc finger FYVE-type containing 1. (782 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	BNIP3	BCL2 interacting protein 3. (188 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (882 aa)
	ATG3	Uncharacterized protein. (158 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	MTMR14	Myotubularin related protein 14. (523 aa)
	ATG14	Autophagy related 14. (515 aa)
	U3IGX0_ANAPP	Uncharacterized protein. (463 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (440 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (958 aa)
	TANK	TRAF family member associated NFKB activator. (481 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (397 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	TBK1	TANK binding kinase 1. (600 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1363 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	LAMP2	Lysosomal associated membrane protein 2. (429 aa)
	NRAS	Uncharacterized protein. (189 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (427 aa)
	RRAGC	Ras related GTP binding C. (395 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (780 aa)
	UVRAG	UV radiation resistance associated. (702 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
	ATG9A	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (851 aa)
	NRBF2	Nuclear receptor binding factor 2. (440 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	VMP1	Vacuole membrane protein 1. (406 aa)
	STX17	Syntaxin 17. (301 aa)
	PIK3R2	Uncharacterized protein. (731 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (539 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	MTMR4	Myotubularin related protein 4. (1141 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
	ATG16L1	WD_REPEATS_REGION domain-containing protein. (608 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CTSL	Uncharacterized protein; Belongs to the peptidase C1 family. (338 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (549 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (489 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	LAMP1	Lysosomal associated membrane protein 1. (415 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (556 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	RRAGD	Ras related GTP binding D. (406 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (397 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	RRAS2	RAS related 2. (203 aa)
	MTMR3	Myotubularin related protein 3. (1218 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (315 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	RRAGB	Ras related GTP binding B. (355 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (735 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	ATG4C	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (459 aa)
	ATG101	Uncharacterized protein. (193 aa)
	RAB39B	RAB39B, member RAS oncogene family. (235 aa)
	SUPT20H	SPT20 homolog, SAGA complex component. (824 aa)
	HMGB1	High mobility group box 1. (281 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (117 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (644 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	ATG2B	Autophagy related 2B. (2077 aa)
	BCL2L1	BCL2 like 1. (238 aa)
	TP53INP2	Tumor protein p53 inducible nuclear protein 2. (263 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2677 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (387 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (167 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	SQSTM1	Uncharacterized protein. (77 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (425 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (621 aa)
	DAPK2	Death associated protein kinase 2. (594 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (217 aa)
	WDR41	WD repeat domain 41. (459 aa)
	RAB7A	RAB7A, member RAS oncogene family. (214 aa)
	RAB1A	RAB1A, member RAS oncogene family. (224 aa)
	RAB33B	RAB33B, member RAS oncogene family. (226 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (481 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	ENSAPLP00000032565	Uncharacterized protein. (427 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSAPLP00000016229	ENSAPLP00000011266	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	INS	ENSAPLP00000016229	ENSAPLP00000012854	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.476
AKT1	MAPK1	ENSAPLP00000016229	ENSAPLP00000005723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
AKT1	MTOR	ENSAPLP00000016229	ENSAPLP00000007032	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.967
AKT1	PDPK1	ENSAPLP00000016229	ENSAPLP00000015587	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.995
AKT1	PIK3CA	ENSAPLP00000016229	ENSAPLP00000012758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.966
AKT1	PIK3CB	ENSAPLP00000016229	ENSAPLP00000003138	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.970
AKT1	PIK3CD	ENSAPLP00000016229	ENSAPLP00000007963	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.948
AKT1	PIK3R1	ENSAPLP00000016229	ENSAPLP00000017936	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.944
AKT1	PIK3R2	ENSAPLP00000016229	ENSAPLP00000011511	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944
AKT1	PPP2CA	ENSAPLP00000016229	ENSAPLP00000014715	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.509
AKT1	PPP2CB	ENSAPLP00000016229	ENSAPLP00000026684	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.509
AKT1	PRKAA1	ENSAPLP00000016229	ENSAPLP00000012543	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.429
AKT1	PRKAA2	ENSAPLP00000016229	ENSAPLP00000007110	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.430
AKT1	PTEN	ENSAPLP00000016229	ENSAPLP00000015564	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.610
AKT1	RHEB	ENSAPLP00000016229	ENSAPLP00000032408	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras homolog, mTORC1 binding.	0.416
AKT1	RPS6KB1	ENSAPLP00000016229	ENSAPLP00000010536	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.560
AKT1	RRAGB	ENSAPLP00000016229	ENSAPLP00000018508	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras related GTP binding B.	0.651
AKT1	RRAGC	ENSAPLP00000016229	ENSAPLP00000009558	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras related GTP binding C.	0.442
AKT1	RRAGD	ENSAPLP00000016229	ENSAPLP00000015930	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras related GTP binding D.	0.442