(95 nodes) Phagosome network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (818 aa)
	NCF4	Uncharacterized protein. (202 aa)
	TFRC	Transferrin receptor. (775 aa)
	SEC61G	SEC61 translocon gamma subunit. (66 aa)
	ATP6V0D2	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	DYNC1I2	Dynein cytoplasmic 1 intermediate chain 2. (800 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (387 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	STX18	Syntaxin 18. (333 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (1055 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (471 aa)
	U3IA71_ANAPP	MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (189 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
	NCF1	Neutrophil cytosolic factor 1. (387 aa)
	U3ID78_ANAPP	C-type lectin domain-containing protein. (200 aa)
	SEC61A1	SEC61 translocon alpha 1 subunit. (476 aa)
	SEC61A2	SEC61 translocon alpha 2 subunit. (476 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (827 aa)
	THBS4	Uncharacterized protein. (1048 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1044 aa)
	U3IH65_ANAPP	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (453 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (894 aa)
	U3IJ51_ANAPP	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
	TUBA8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
	DYNC2H1	Uncharacterized protein. (1259 aa)
	ATP6V1G3	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (530 aa)
	CYBB	Cytochrome b-245 beta chain. (570 aa)
	LAMP2	Lysosomal associated membrane protein 2. (429 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (1022 aa)
	THBS2	Thrombospondin 2. (1182 aa)
	CANX	Calnexin. (516 aa)
	COMP	Uncharacterized protein. (765 aa)
	U3IQV6_ANAPP	Uncharacterized protein. (724 aa)
	TUBA4A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (430 aa)
	ATP6V1C2	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
	CALR3	Calreticulin. (389 aa)
	EPX	Eosinophil peroxidase. (789 aa)
	SEC61B	SEC61 translocon beta subunit. (193 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (713 aa)
	U3IVN9_ANAPP	Uncharacterized protein. (1460 aa)
	TUBB6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (545 aa)
	U3IXK2_ANAPP	Uncharacterized protein. (1447 aa)
	U3IXS0_ANAPP	Uncharacterized protein. (1425 aa)
	U3IY67_ANAPP	Uncharacterized protein. (1442 aa)
	TLR4	Toll like receptor 4. (843 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (330 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate. (726 aa)
	ATP6V1E1	Uncharacterized protein. (226 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1420 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (835 aa)
	DYNC1LI2	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (625 aa)
	DYNC1H1	Dynein cytoplasmic 1 heavy chain 1. (4809 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2091 aa)
	CTSL	Uncharacterized protein; Belongs to the peptidase C1 family. (338 aa)
	U3J3X4_ANAPP	LRRCT domain-containing protein. (553 aa)
	ATP6AP1	Uncharacterized protein. (481 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (850 aa)
	U3J4H5_ANAPP	IGc1 domain-containing protein. (212 aa)
	ITGB2	Integrin beta. (773 aa)
	NCF2	Neutrophil cytosolic factor 2. (513 aa)
	ATP6V1D	ATPase H+ transporting V1 subunit D. (247 aa)
	TAP2	Uncharacterized protein. (606 aa)
	ATP6V0E1	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	LAMP1	Lysosomal associated membrane protein 1. (415 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
	COLEC12	Collectin subfamily member 12. (744 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (461 aa)
	STX7	Syntaxin 7; Belongs to the syntaxin family. (257 aa)
	TUBB3	Uncharacterized protein; Belongs to the tubulin family. (200 aa)
	MBL2	Mannose binding lectin 2. (256 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1464 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (156 aa)
	ATP6V0D1-2	Uncharacterized protein. (67 aa)
	MARCO	SRCR domain-containing protein. (500 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (141 aa)
	ENSAPLP00000019888	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	MRC2	Uncharacterized protein. (407 aa)
	ENSAPLP00000021209	Uncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (579 aa)
	TUBB4B	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
	THBS1	Thrombospondin 1. (1178 aa)
	ACTB-2	Uncharacterized protein. (376 aa)
	COLEC11	Collectin subfamily member 11. (271 aa)
	RILP	RH1 domain-containing protein. (244 aa)
	M6PR	Uncharacterized protein. (303 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (617 aa)
	ENSAPLP00000026694	Uncharacterized protein. (1391 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (504 aa)
	RAB5A	RAB5A, member RAS oncogene family. (245 aa)
	TUBB1	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	EEA1	Early endosome antigen 1. (1452 aa)
	ATP6V1H	ATPase H+ transporting V1 subunit H. (519 aa)
	RAB7A	RAB7A, member RAS oncogene family. (214 aa)
	ENSAPLP00000031777	Tubulin domain-containing protein. (142 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB-2	CANX	ENSAPLP00000022136	ENSAPLP00000009350	Uncharacterized protein.	Calnexin.	0.574
ACTB-2	DYNC1I2	ENSAPLP00000022136	ENSAPLP00000002800	Uncharacterized protein.	Dynein cytoplasmic 1 intermediate chain 2.	0.478
ACTB-2	EEA1	ENSAPLP00000022136	ENSAPLP00000027486	Uncharacterized protein.	Early endosome antigen 1.	0.518
ACTB-2	ENSAPLP00000021209	ENSAPLP00000022136	ENSAPLP00000021209	Uncharacterized protein.	Uncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.476
ACTB-2	ENSAPLP00000031777	ENSAPLP00000022136	ENSAPLP00000031777	Uncharacterized protein.	Tubulin domain-containing protein.	0.491
ACTB-2	ITGB1	ENSAPLP00000022136	ENSAPLP00000009107	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.554
ACTB-2	ITGB2	ENSAPLP00000022136	ENSAPLP00000014751	Uncharacterized protein.	Integrin beta.	0.616
ACTB-2	ITGB3	ENSAPLP00000022136	ENSAPLP00000004048	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.640
ACTB-2	ITGB5	ENSAPLP00000022136	ENSAPLP00000007149	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.572
ACTB-2	LAMP1	ENSAPLP00000022136	ENSAPLP00000015455	Uncharacterized protein.	Lysosomal associated membrane protein 1.	0.596
ACTB-2	RAC1	ENSAPLP00000022136	ENSAPLP00000003050	Uncharacterized protein.	Rac family small GTPase 1.	0.501
ACTB-2	TFRC	ENSAPLP00000022136	ENSAPLP00000002263	Uncharacterized protein.	Transferrin receptor.	0.603
ACTB-2	TLR4	ENSAPLP00000022136	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.622
ACTB-2	TUBA4A	ENSAPLP00000022136	ENSAPLP00000010045	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.467
ACTB-2	TUBA8	ENSAPLP00000022136	ENSAPLP00000007515	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.477
ACTB-2	TUBB1	ENSAPLP00000022136	ENSAPLP00000027290	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.405
ACTB-2	TUBB3	ENSAPLP00000022136	ENSAPLP00000017055	Uncharacterized protein.	Uncharacterized protein; Belongs to the tubulin family.	0.459
ACTB-2	U3IH65_ANAPP	ENSAPLP00000022136	ENSAPLP00000006587	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.464
ACTB-2	U3IJ51_ANAPP	ENSAPLP00000022136	ENSAPLP00000007273	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.513
ATP6AP1	ATP6V0A1	ENSAPLP00000014215	ENSAPLP00000019118	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.978