STRINGSTRING
LAMTOR2 LAMTOR2 FZD7 FZD7 FZD2 FZD2 TSC1 TSC1 MIOS MIOS MAPKAP1 MAPKAP1 WNT2 WNT2 ULK2 ULK2 ATP6V1C1 ATP6V1C1 PIK3CB PIK3CB SEC13 SEC13 FLCN FLCN WDR24 WDR24 WNT9B WNT9B CASTOR2 CASTOR2 WNT5B WNT5B LPIN3 LPIN3 SEH1L SEH1L MAPK1 MAPK1 DVL1 DVL1 TELO2 TELO2 FZD1 FZD1 U3IGX0_ANAPP U3IGX0_ANAPP STK11 STK11 DEPDC5 DEPDC5 MTOR MTOR PRKAA2 PRKAA2 FZD9 FZD9 DEPTOR DEPTOR RPS6KA6 RPS6KA6 PIK3CD PIK3CD LRP5 LRP5 IGF1R IGF1R ATP6V1G3 ATP6V1G3 CAB39L CAB39L NRAS NRAS RRAGC RRAGC WNT11 WNT11 SOS1 SOS1 ATP6V1C2 ATP6V1C2 WNT7B WNT7B IGF1 IGF1 RPS6KB1 RPS6KB1 RPS6KA2 RPS6KA2 AKT3 AKT3 PIK3R2 PIK3R2 WNT5A WNT5A LRP6 LRP6 HRAS HRAS ATP6V1E1 ATP6V1E1 PRKAA1 PRKAA1 PIK3CA PIK3CA INS INS PRR5 PRR5 WNT8A WNT8A WNT7A WNT7A RPS6KA3 RPS6KA3 RAF1 RAF1 WNT2B WNT2B FZD3 FZD3 STRADB STRADB RHOA RHOA NPRL2 NPRL2 FNIP2 FNIP2 ATP6V1D ATP6V1D U3J6Z6_ANAPP U3J6Z6_ANAPP U3J721_ANAPP U3J721_ANAPP MAP2K1 MAP2K1 WNT8B WNT8B PTEN PTEN PDPK1 PDPK1 WDR59 WDR59 EIF4EBP1 EIF4EBP1 EIF4E EIF4E KRAS KRAS RRAGD RRAGD EIF4E2 EIF4E2 ATP6V1B2 ATP6V1B2 AKT1 AKT1 WNT3 WNT3 WNT4 WNT4 SGK1 SGK1 WNT10A WNT10A TBC1D7 TBC1D7 SKP2 SKP2 PIK3R1 PIK3R1 RPS6 RPS6 RRAGB RRAGB FNIP1 FNIP1 PRKCA PRKCA LPIN1 LPIN1 LPIN2 LPIN2 SLC38A9 SLC38A9 RPS6KA1 RPS6KA1 GRB10 GRB10 SOS2 SOS2 DVL3 DVL3 SLC7A5 SLC7A5 INSR INSR CAB39 CAB39 ATP6V1A ATP6V1A CASTOR1 CASTOR1 WNT16 WNT16 GSK3B GSK3B RNF152 RNF152 PRKCB PRKCB LAMTOR3 LAMTOR3 FZD6 FZD6 IKBKB IKBKB FZD8 FZD8 ATP6V1H ATP6V1H STRADA STRADA FZD4 FZD4 GRB2 GRB2 FZD5 FZD5 TTI1 TTI1 RHEB RHEB ENSAPLP00000032565 ENSAPLP00000032565 NPRL3 NPRL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
TSC1TSC complex subunit 1. (1158 aa)
MIOSMeiosis regulator for oocyte development. (877 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (319 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1077 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (387 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
WDR24WD repeat domain 24. (813 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CASTOR2Uncharacterized protein. (329 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
LPIN3Lipin 3. (900 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (419 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
DVL1Dishevelled segment polarity protein 1. (712 aa)
TELO2Telomere maintenance 2. (815 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
U3IGX0_ANAPPUncharacterized protein. (463 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (440 aa)
DEPDC5DEP domain-containing protein. (870 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
DEPTORDEP domain containing MTOR interacting protein. (397 aa)
RPS6KA6Ribosomal protein S6 kinase. (746 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
LRP5Uncharacterized protein. (471 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
NRASUncharacterized protein. (189 aa)
RRAGCRas related GTP binding C. (395 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1323 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
IGF1Insulin like growth factor 1. (153 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R2Uncharacterized protein. (731 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1603 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ATP6V1E1Uncharacterized protein. (226 aa)
PRKAA1Non-specific serine/threonine protein kinase. (539 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
PRR5Proline rich 5. (413 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (711 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
STRADBSTE20 related adaptor beta. (416 aa)
RHOARas homolog family member A. (193 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (378 aa)
FNIP2Folliculin interacting protein 2. (1163 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
U3J6Z6_ANAPPUncharacterized protein. (427 aa)
U3J721_ANAPPProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
WDR59WD repeat domain 59. (849 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (100 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (230 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RRAGDRas related GTP binding D. (406 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (320 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (109 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
TBC1D7Uncharacterized protein. (76 aa)
SKP2S-phase kinase associated protein 2. (671 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RPS6Uncharacterized protein. (492 aa)
RRAGBRas related GTP binding B. (355 aa)
FNIP1Folliculin interacting protein 1. (1222 aa)
PRKCAProtein kinase C. (649 aa)
LPIN1Lipin 1. (1002 aa)
LPIN2Lipin 2. (918 aa)
SLC38A9Solute carrier family 38 member 9. (698 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (892 aa)
GRB10Growth factor receptor bound protein 10. (615 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
DVL3Dishevelled segment polarity protein 3. (901 aa)
SLC7A5Solute carrier family 7 member 5. (532 aa)
INSRTyrosine-protein kinase receptor. (1353 aa)
CAB39Calcium binding protein 39. (341 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (397 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
RNF152Ring finger protein 152. (203 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
LAMTOR3Uncharacterized protein. (142 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (890 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (778 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (682 aa)
ATP6V1HATPase H+ transporting V1 subunit H. (519 aa)
STRADASTE20 related adaptor alpha. (181 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
FZD5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
TTI1TELO2 interacting protein 1. (1190 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
ENSAPLP00000032565Uncharacterized protein. (427 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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