(43 nodes) VEGF signaling pathway network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PLA2G4F	PLA2c domain-containing protein. (530 aa)
	MAPK13	Mitogen-activated protein kinase 13. (158 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	MAPK12	Mitogen-activated protein kinase. (361 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (510 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	U3IGX0_ANAPP	Uncharacterized protein. (463 aa)
	PLCG1	Phosphoinositide phospholipase C. (502 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	U3IN59_ANAPP	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1295 aa)
	PLA2G4B	Phospholipase A2. (911 aa)
	NRAS	Uncharacterized protein. (189 aa)
	PLCG2	Phosphoinositide phospholipase C. (1086 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PIK3R2	Uncharacterized protein. (731 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (603 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (397 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	RAC3	Rac family small GTPase 3. (189 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	SHC2	Uncharacterized protein. (781 aa)
	PTK2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (507 aa)
	SPHK1	Sphingosine kinase 1. (778 aa)
	PRKCA	Protein kinase C. (649 aa)
	CDC42	Cell division cycle 42. (282 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (387 aa)
	NFATC2	Nuclear factor of activated T cells 2. (930 aa)
	PXN-2	Uncharacterized protein. (636 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
	PPP3R1	Uncharacterized protein. (170 aa)
	HSPB1	SHSP domain-containing protein. (517 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSAPLP00000016229	ENSAPLP00000011266	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CASP9	ENSAPLP00000016229	ENSAPLP00000008534	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.959
AKT1	HSPB1	ENSAPLP00000016229	ENSAPLP00000029845	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SHSP domain-containing protein.	0.404
AKT1	MAPK1	ENSAPLP00000016229	ENSAPLP00000005723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
AKT1	PIK3CA	ENSAPLP00000016229	ENSAPLP00000012758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.966
AKT1	PIK3CB	ENSAPLP00000016229	ENSAPLP00000003138	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.970
AKT1	PIK3CD	ENSAPLP00000016229	ENSAPLP00000007963	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.948
AKT1	PIK3R1	ENSAPLP00000016229	ENSAPLP00000017936	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.944
AKT1	PIK3R2	ENSAPLP00000016229	ENSAPLP00000011511	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944
AKT1	U3IGX0_ANAPP	ENSAPLP00000016229	ENSAPLP00000006492	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944
AKT3	AKT1	ENSAPLP00000011266	ENSAPLP00000016229	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT3	CASP9	ENSAPLP00000011266	ENSAPLP00000008534	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.951
AKT3	CDC42	ENSAPLP00000011266	ENSAPLP00000021122	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division cycle 42.	0.552
AKT3	HSPB1	ENSAPLP00000011266	ENSAPLP00000029845	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SHSP domain-containing protein.	0.404
AKT3	MAPK1	ENSAPLP00000011266	ENSAPLP00000005723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
AKT3	PIK3CA	ENSAPLP00000011266	ENSAPLP00000012758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.976
AKT3	PIK3CB	ENSAPLP00000011266	ENSAPLP00000003138	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.948
AKT3	PIK3CD	ENSAPLP00000011266	ENSAPLP00000007963	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.948
AKT3	PIK3R1	ENSAPLP00000011266	ENSAPLP00000017936	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.945
AKT3	PIK3R2	ENSAPLP00000011266	ENSAPLP00000011511	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.944