85 items (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (176 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1142 aa)
	U3I3U9_ANAPP	Uncharacterized protein. (346 aa)
	CALML4	Calmodulin like 4. (195 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2613 aa)
	GNB3	G protein subunit beta 3. (331 aa)
	BECN1	Uncharacterized protein. (452 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	RYR3	Ryanodine receptor 3. (4803 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1212 aa)
	MYL3	Myosin light chain 3. (193 aa)
	ACTA2	Actin alpha 2, smooth muscle. (382 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (553 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	SMAD3	Mothers against decapentaplegic homolog. (426 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1104 aa)
	CCN2	Cellular communication network factor 2. (347 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1225 aa)
	NRAS	Uncharacterized protein. (189 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (273 aa)
	MYLK3	Myosin light chain kinase 3. (782 aa)
	KLF2	Uncharacterized protein. (380 aa)
	GNAI2	G protein subunit alpha i2. (321 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (780 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
	RYR2	Ryanodine receptor 2. (4940 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	GNG13	G protein subunit gamma 13. (67 aa)
	GNB4	G protein subunit beta 4. (343 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (539 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1420 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (916 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1175 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2699 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1372 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (841 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (804 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (397 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1151 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MEF2A	Myocyte enhancer factor 2A. (546 aa)
	RRAS2	RAS related 2. (203 aa)
	GNB5	G protein subunit beta 5. (401 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1110 aa)
	PRKCE	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
	RPS6	Uncharacterized protein. (492 aa)
	CCND1	Cyclin_C domain-containing protein. (153 aa)
	SPHK1	Sphingosine kinase 1. (778 aa)
	MYL4	Uncharacterized protein. (290 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	ENSAPLP00000021377	Protein kinase domain-containing protein. (177 aa)
	ENSAPLP00000022266	Protein kinase domain-containing protein. (369 aa)
	GNG11	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	PDE3B	PDEase domain-containing protein. (177 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (117 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	MYLK4	Myosin light chain kinase family member 4. (714 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2677 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV. (601 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (834 aa)
	TFAM	Transcription factor A, mitochondrial. (379 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	PLIN1	Perilipin 1. (639 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	CALML3	ENSAPLP00000005669	ENSAPLP00000006875	Actin alpha 2, smooth muscle.	Calmodulin like 3; Belongs to the calmodulin family.	0.405
ACTA2	ITPR2	ENSAPLP00000005669	ENSAPLP00000014993	Actin alpha 2, smooth muscle.	Inositol 1,4,5-trisphosphate receptor type 2.	0.410
ACTA2	MYL4	ENSAPLP00000005669	ENSAPLP00000019860	Actin alpha 2, smooth muscle.	Uncharacterized protein.	0.485
ACTA2	PLCB4	ENSAPLP00000005669	ENSAPLP00000013480	Actin alpha 2, smooth muscle.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.460
ADCY1	ADCY2	ENSAPLP00000000524	ENSAPLP00000008372	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.451
ADCY1	ADCY3	ENSAPLP00000000524	ENSAPLP00000028546	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.947
ADCY1	ADCY5	ENSAPLP00000000524	ENSAPLP00000005027	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.559
ADCY1	ADCY7	ENSAPLP00000000524	ENSAPLP00000013771	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.461
ADCY1	ADCY9	ENSAPLP00000000524	ENSAPLP00000015193	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.655
ADCY1	CALM1	ENSAPLP00000000524	ENSAPLP00000020112	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.933
ADCY1	CALML3	ENSAPLP00000000524	ENSAPLP00000006875	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.933
ADCY1	CALML4	ENSAPLP00000000524	ENSAPLP00000002547	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.917
ADCY1	GNAI1	ENSAPLP00000000524	ENSAPLP00000004363	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.943
ADCY1	GNAI2	ENSAPLP00000000524	ENSAPLP00000009642	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.943
ADCY1	GNAI3	ENSAPLP00000000524	ENSAPLP00000020074	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.943
ADCY1	GNB3	ENSAPLP00000000524	ENSAPLP00000002795	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 3.	0.800
ADCY1	GNB4	ENSAPLP00000000524	ENSAPLP00000012022	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 4.	0.803
ADCY1	GNB5	ENSAPLP00000000524	ENSAPLP00000016983	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 5.	0.850
ADCY1	GNG10	ENSAPLP00000000524	ENSAPLP00000031667	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.844
ADCY1	GNG11	ENSAPLP00000000524	ENSAPLP00000022549	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.843