(23 nodes) Intestinal immune network for IgA production network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD28	CD28 molecule. (222 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (338 aa)
	CCR9	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (944 aa)
	IL-2	Interleukin; Belongs to the IL-15/IL-21 family. (140 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (306 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (998 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (324 aa)
	AICDA	Activation induced cytidine deaminase. (203 aa)
	U3J4H5_ANAPP	IGc1 domain-containing protein. (212 aa)
	CXCL12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (165 aa)
	IL10	Interleukin 10. (177 aa)
	PIGR	Uncharacterized protein. (714 aa)
	CD40	TNFR-Cys domain-containing protein. (214 aa)
	ENSAPLP00000018531	DUF1968 domain-containing protein. (178 aa)
	ENSAPLP00000018850	Ig-like domain-containing protein. (376 aa)
	MADCAM1	Uncharacterized protein. (556 aa)
	ENSAPLP00000020285	IGv domain-containing protein. (231 aa)
	IL6	Uncharacterized protein. (350 aa)
	ICOSLG	Uncharacterized protein. (316 aa)
	CD86	CD86 molecule. (341 aa)
	CCR10	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	TNFRSF13B	TACI-CRD2 domain-containing protein. (363 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	CD40	ENSAPLP00000013772	ENSAPLP00000016411	Activation induced cytidine deaminase.	TNFR-Cys domain-containing protein.	0.755
AICDA	CD40LG	ENSAPLP00000013772	ENSAPLP00000012063	Activation induced cytidine deaminase.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.704
AICDA	CD86	ENSAPLP00000013772	ENSAPLP00000026026	Activation induced cytidine deaminase.	CD86 molecule.	0.411
AICDA	CXCR4	ENSAPLP00000013772	ENSAPLP00000001302	Activation induced cytidine deaminase.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.484
AICDA	TNFSF13B	ENSAPLP00000013772	ENSAPLP00000008380	Activation induced cytidine deaminase.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.587
CCR10	CCR9	ENSAPLP00000028709	ENSAPLP00000001406	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.417
CCR10	CXCL12	ENSAPLP00000028709	ENSAPLP00000015191	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.679
CCR10	CXCR4	ENSAPLP00000028709	ENSAPLP00000001302	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.553
CCR9	CCR10	ENSAPLP00000001406	ENSAPLP00000028709	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.417
CCR9	CD86	ENSAPLP00000001406	ENSAPLP00000026026	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	CD86 molecule.	0.411
CCR9	CXCL12	ENSAPLP00000001406	ENSAPLP00000015191	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.733
CCR9	CXCR4	ENSAPLP00000001406	ENSAPLP00000001302	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.557
CCR9	IL10	ENSAPLP00000001406	ENSAPLP00000015242	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	Interleukin 10.	0.464
CCR9	PIGR	ENSAPLP00000001406	ENSAPLP00000015483	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.477
CD28	CD40	ENSAPLP00000001220	ENSAPLP00000016411	CD28 molecule.	TNFR-Cys domain-containing protein.	0.487
CD28	CD40LG	ENSAPLP00000001220	ENSAPLP00000012063	CD28 molecule.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.627
CD28	CD86	ENSAPLP00000001220	ENSAPLP00000026026	CD28 molecule.	CD86 molecule.	0.995
CD28	ENSAPLP00000020285	ENSAPLP00000001220	ENSAPLP00000020285	CD28 molecule.	IGv domain-containing protein.	0.557
CD28	ICOSLG	ENSAPLP00000001220	ENSAPLP00000023627	CD28 molecule.	Uncharacterized protein.	0.900
CD28	IL-2	ENSAPLP00000001220	ENSAPLP00000006460	CD28 molecule.	Interleukin; Belongs to the IL-15/IL-21 family.	0.748