(92 nodes) Insulin signaling pathway network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	IRS4	Insulin receptor substrate 4. (1128 aa)
	SOCS2	Suppressor of cytokine signaling 2. (143 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (338 aa)
	TSC1	TSC complex subunit 1. (1158 aa)
	FASN	Fatty acid synthase. (2513 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	CALML4	Calmodulin like 4. (195 aa)
	EXOC7	Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (711 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	FOXO1	Forkhead box O1. (678 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
	SHC4	SHC adaptor protein 4. (631 aa)
	PHKA1	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1210 aa)
	MAPK10	Mitogen-activated protein kinase. (384 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (400 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (301 aa)
	U3IGX0_ANAPP	Uncharacterized protein. (463 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (440 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	CRK	CRK proto-oncogene, adaptor protein. (306 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (436 aa)
	SHC1	SHC adaptor protein 1. (616 aa)
	NRAS	Uncharacterized protein. (189 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (273 aa)
	HK1	Hexokinase 1. (925 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
	PYGB	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1323 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	SOCS4	Suppressor of cytokine signaling 4. (436 aa)
	HKDC1	Hexokinase domain containing 1. (917 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (301 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PIK3R2	Uncharacterized protein. (731 aa)
	CBLB	Cbl proto-oncogene B. (971 aa)
	SOCS3	Suppressor of cytokine signaling 3. (209 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (539 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (141 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CBL	Cbl proto-oncogene. (814 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit 3D. (307 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (773 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (556 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (100 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (331 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (230 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (320 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (397 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
	GYS2	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (689 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	SHC2	Uncharacterized protein. (781 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	RPS6	Uncharacterized protein. (492 aa)
	FBP2	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (340 aa)
	PPP1R3E	Protein phosphatase 1 regulatory subunit 3E. (328 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1142 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (421 aa)
	PDE3B	PDEase domain-containing protein. (177 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
	MKNK2	MAPK interacting serine/threonine kinase 2. (286 aa)
	INSR	Tyrosine-protein kinase receptor. (1353 aa)
	HK3	Hexokinase 3. (758 aa)
	RHOQ	Ras homolog family member Q. (205 aa)
	MKNK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (438 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2444 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	PHKA2	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1221 aa)
	PHKG1	Protein kinase domain-containing protein. (189 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (778 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (834 aa)
	SREBF1	Uncharacterized protein. (322 aa)
	G6PC	Glucose-6-phosphatase catalytic subunit. (358 aa)
	GRB2	Growth factor receptor bound protein 2. (203 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	PHKB	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1130 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	FASN	ENSAPLP00000025863	ENSAPLP00000002286	Acetyl-CoA carboxylase alpha.	Fatty acid synthase.	0.982
ACACA	PRKAA1	ENSAPLP00000025863	ENSAPLP00000012543	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.925
ACACA	PRKAA2	ENSAPLP00000025863	ENSAPLP00000007110	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.934
ACACA	PRKAB1	ENSAPLP00000025863	ENSAPLP00000009214	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit beta 1.	0.908
ACACA	PRKAB2	ENSAPLP00000025863	ENSAPLP00000016162	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.922
ACACA	PRKAG2	ENSAPLP00000025863	ENSAPLP00000004149	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.921
ACACA	SREBF1	ENSAPLP00000025863	ENSAPLP00000031412	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.711
AKT1	AKT3	ENSAPLP00000016229	ENSAPLP00000011266	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	FOXO1	ENSAPLP00000016229	ENSAPLP00000003516	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.972
AKT1	GSK3B	ENSAPLP00000016229	ENSAPLP00000026002	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.956
AKT1	IKBKB	ENSAPLP00000016229	ENSAPLP00000029764	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.956
AKT1	INS	ENSAPLP00000016229	ENSAPLP00000012854	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.476
AKT1	MAPK1	ENSAPLP00000016229	ENSAPLP00000005723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.925
AKT1	MTOR	ENSAPLP00000016229	ENSAPLP00000007032	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.967
AKT1	PDE3B	ENSAPLP00000016229	ENSAPLP00000022576	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PDEase domain-containing protein.	0.915
AKT1	PDPK1	ENSAPLP00000016229	ENSAPLP00000015587	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.995
AKT1	PIK3CA	ENSAPLP00000016229	ENSAPLP00000012758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.966
AKT1	PIK3CB	ENSAPLP00000016229	ENSAPLP00000003138	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.970
AKT1	PIK3CD	ENSAPLP00000016229	ENSAPLP00000007963	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.948
AKT1	PIK3R1	ENSAPLP00000016229	ENSAPLP00000017936	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.944