(96 nodes) Influenza A network (Anas platyrhynchos)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFNGR1	Interferon gamma receptor 1. (438 aa)
	U3I3J8_ANAPP	Uncharacterized protein. (207 aa)
	BAK1	BCL2 antagonist/killer 1. (306 aa)
	RAE1	Ribonucleic acid export 1. (228 aa)
	MAVS	CARD_2 domain-containing protein. (619 aa)
	U3I6M6_ANAPP	Uncharacterized protein. (184 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	XPO1	CRM1_C domain-containing protein. (564 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1089 aa)
	U3I9W7_ANAPP	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
	KPNA1	Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
	FADD	Uncharacterized protein. (195 aa)
	IL18	Interleukin-18. (197 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (368 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (214 aa)
	U3IGX0_ANAPP	Uncharacterized protein. (463 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	TBK1	TANK binding kinase 1. (600 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (446 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	ADAR	Adenosine deaminase RNA specific. (1164 aa)
	U3IRD8_ANAPP	Uncharacterized protein. (934 aa)
	KPNA2	Importin subunit alpha; Belongs to the importin alpha family. (529 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1247 aa)
	EP300	E1A binding protein p300. (2355 aa)
	U3ITT3_ANAPP	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1003 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (318 aa)
	RAB11B	Uncharacterized protein. (211 aa)
	IFNGR2	Interferon gamma receptor 2. (338 aa)
	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (584 aa)
	IFNAR2	Uncharacterized protein. (532 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PIK3R2	Uncharacterized protein. (731 aa)
	SOCS3	Suppressor of cytokine signaling 3. (209 aa)
	JAK1	Tyrosine-protein kinase. (1152 aa)
	TLR4	Toll like receptor 4. (843 aa)
	CXCL8-3	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	STAT1	Signal transducer and activator of transcription. (869 aa)
	CALCOCO2	Uncharacterized protein. (484 aa)
	U3J1K3_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	NLRX1	NLR family member X1. (973 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (725 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (676 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (466 aa)
	RAB11A	RAB11A, member RAS oncogene family. (401 aa)
	U3J6D9_ANAPP	Uncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	U3J6Z6_ANAPP	Uncharacterized protein. (427 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (721 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	TNFSF10	TNF superfamily member 10; Belongs to the tumor necrosis factor family. (295 aa)
	CCL5	C-C motif chemokine. (90 aa)
	KPNA5	Karyopherin subunit alpha 5. (614 aa)
	ENSAPLP00000017420	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (485 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (998 aa)
	FAS	Uncharacterized protein. (461 aa)
	PRKCA	Protein kinase C. (649 aa)
	CREBBP	CREB binding protein. (2396 aa)
	IL6	Uncharacterized protein. (350 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (371 aa)
	ENSAPLP00000021652	Uncharacterized protein. (243 aa)
	ACTB-2	Uncharacterized protein. (376 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (541 aa)
	TRADD	TNFRSF1A associated via death domain. (429 aa)
	CXCL8-5	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (277 aa)
	CXCL8-6	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (155 aa)
	IRF7	Interferon regulatory factor 7. (523 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	SLC25A4	Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (455 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (167 aa)
	PABPN1L	Poly(A) binding protein nuclear 1 like, cytoplasmic. (315 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (311 aa)
	ENSAPLP00000028410	Uncharacterized protein. (157 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	CIITA	NACHT domain-containing protein. (1109 aa)
	SLC25A5	Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (442 aa)
	SLC25A6	Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (331 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (778 aa)
	RNASEL	Uncharacterized protein. (772 aa)
	CPSF4	Cleavage and polyadenylation specific factor 4. (243 aa)
	ENSAPLP00000030796	Uncharacterized protein. (1090 aa)
	ENSAPLP00000030826	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (121 aa)
	TICAM1	TRIF-NTD domain-containing protein. (507 aa)
	CCND3	Cyclin_C domain-containing protein; Belongs to the cyclin family. (321 aa)
	ENSAPLP00000032274	Protein kinase domain-containing protein. (192 aa)
	NXT2	Nuclear transport factor 2 like export factor 2. (113 aa)
	KPNA7-2	IBB domain-containing protein. (77 aa)

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB-2	CASP8	ENSAPLP00000022136	ENSAPLP00000014720	Uncharacterized protein.	Caspase 8; Belongs to the peptidase C14A family.	0.592
ACTB-2	CASP9	ENSAPLP00000022136	ENSAPLP00000008534	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.621
ACTB-2	CDK6	ENSAPLP00000022136	ENSAPLP00000021367	Uncharacterized protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.420
ACTB-2	ENSAPLP00000030826	ENSAPLP00000022136	ENSAPLP00000030826	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.480
ACTB-2	IFNG	ENSAPLP00000022136	ENSAPLP00000012661	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.596
ACTB-2	IL6	ENSAPLP00000022136	ENSAPLP00000020478	Uncharacterized protein.	Uncharacterized protein.	0.611
ACTB-2	MYD88	ENSAPLP00000022136	ENSAPLP00000028214	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.598
ACTB-2	NFKBIA	ENSAPLP00000022136	ENSAPLP00000010772	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.640
ACTB-2	STAT1	ENSAPLP00000022136	ENSAPLP00000013135	Uncharacterized protein.	Signal transducer and activator of transcription.	0.499
ACTB-2	TBK1	ENSAPLP00000022136	ENSAPLP00000008155	Uncharacterized protein.	TANK binding kinase 1.	0.413
ACTB-2	TLR4	ENSAPLP00000022136	ENSAPLP00000012401	Uncharacterized protein.	Toll like receptor 4.	0.622
ACTB-2	U3ITT3_ANAPP	ENSAPLP00000022136	ENSAPLP00000010656	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.480
ACTB-2	U3J1K3_ANAPP	ENSAPLP00000022136	ENSAPLP00000013380	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.467
ACTB-2	U3J6D9_ANAPP	ENSAPLP00000022136	ENSAPLP00000015066	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.594
ADAR	IFIH1	ENSAPLP00000009404	ENSAPLP00000010681	Adenosine deaminase RNA specific.	Interferon induced with helicase C domain 1.	0.646
ADAR	RNASEL	ENSAPLP00000009404	ENSAPLP00000029801	Adenosine deaminase RNA specific.	Uncharacterized protein.	0.659
AKT1	AKT3	ENSAPLP00000016229	ENSAPLP00000011266	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CASP9	ENSAPLP00000016229	ENSAPLP00000008534	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.959
AKT1	IKBKB	ENSAPLP00000016229	ENSAPLP00000029764	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.956
AKT1	IKBKE	ENSAPLP00000016229	ENSAPLP00000014214	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.461