(71 nodes) Regulation of B cell activation network (Anser cygnoides)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLCF1	Cardiotrophin like cytokine factor 1. (228 aa)
	PMS2	Mismatch repair endonuclease PMS2. (912 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog 1 isoform X1. (418 aa)
	XBP1	X box-binding protein 1. (257 aa)
	ENSACDP00005011947	annotation not available (204 aa)
	ENSACDP00005011972	annotation not available (172 aa)
	ENSACDP00005009934	annotation not available (141 aa)
	ENSACDP00005009564	annotation not available (108 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3 isoform X1. (809 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1214 aa)
	STAT6	Signal transducer and activator of transcription 6. (1069 aa)
	MZB1	Marginal zone B and B1 cell specific protein. (221 aa)
	KMT5B	Histone-lysine N-methyltransferase SUV420H1 isoform X1. (857 aa)
	PPP2R3C	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (481 aa)
	SAMSN1	SAM domain-containing protein SAMSN-1. (461 aa)
	MLH1	DNA mismatch repair protein Mlh1 isoform X1. (756 aa)
	THOC1	THO complex subunit 1. (664 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1107 aa)
	NSD2	LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2. (1394 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1260 aa)
	BLK	Tyrosine-protein kinase Blk isoform X1. (526 aa)
	ATM	LOW QUALITY PROTEIN: serine-protein kinase ATM-like. (2818 aa)
	BST1	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1. (315 aa)
	RIF1	Telomere-associated protein RIF1. (2314 aa)
	TNFSF13B	Tumor necrosis factor ligand superfamily member 13B. (302 aa)
	THEMIS2	Protein THEMIS2. (585 aa)
	NDFIP1	NEDD4 family-interacting protein 1. (219 aa)
	ENSACDP00005002149	annotation not available (370 aa)
	IL10	Interleukin 10. (177 aa)
	ATAD5	ATPase family AAA domain-containing protein 5 isoform X1. (1822 aa)
	BANK1	B-cell scaffold protein with ankyrin repeats isoform X1. (737 aa)
	SASH3	SAM and SH3 domain-containing protein 3 isoform X1. (453 aa)
	IL7	Interleukin-7-like. (181 aa)
	ENSACDP00005011948	annotation not available (175 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type 6 isoform X1. (609 aa)
	AKIRIN2	Akirin-2. (194 aa)
	CARD11	Caspase recruitment domain-containing protein 11 isoform X1. (1169 aa)
	SYK	LOW QUALITY PROTEIN: tyrosine-protein kinase SYK. (636 aa)
	TIRAP	Toll/interleukin-1 receptor domain-containing adapter protein isoform X1. (359 aa)
	ENSACDP00005014747	annotation not available (454 aa)
	TNFRSF4	Tumor necrosis factor receptor superfamily member 4 isoform X1. (71 aa)
	ENSACDP00005015381	annotation not available (223 aa)
	ENSACDP00005015382	annotation not available (223 aa)
	ENSACDP00005015401	annotation not available (98 aa)
	ENSACDP00005015407	annotation not available (128 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (153 aa)
	BCL2	BCL2 apoptosis regulator. (359 aa)
	IKZF3	Zinc finger protein Aiolos isoform X1. (559 aa)
	IL21	Interleukin 21. (141 aa)
	ENSACDP00005016250	annotation not available (705 aa)
	TP53BP1	Tumor suppressor p53-binding protein 1. (1785 aa)
	MSH6	DNA mismatch repair protein MSH6. (1298 aa)
	MSH2	DNA mismatch repair protein MSH2. (1059 aa)
	IL6	Interleukin 6. (234 aa)
	BCL6	B-cell lymphoma 6 protein. (709 aa)
	TFRC	Transferrin receptor protein 1. (760 aa)
	TNFRSF21	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 21. (643 aa)
	PCID2	Nuclear mRNA export protein PCID2/THP1. (433 aa)
	LYN	Tyrosine-protein kinase Lyn isoform X1. (513 aa)
	EXOSC3	Exosome complex component RRP40. (264 aa)
	ENSACDP00005022668	B-cell receptor CD22-like. (909 aa)
	CD40	CD40 molecule. (408 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (842 aa)
	HMCES	Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein. (340 aa)
	ENSACDP00005023724	annotation not available (95 aa)
	NFAM1	NFAT activation molecule 1 isoform X1. (354 aa)
	ENSACDP00005024048	annotation not available (357 aa)
	PAWR	PRKC apoptosis WT1 regulator protein. (381 aa)
	GPR183	G-protein coupled receptor 183-like. (368 aa)
	PARP3	poly(ADP-ribose) polymerase family member 3. (481 aa)
	SUPT6H	LOW QUALITY PROTEIN: transcription elongation factor SPT6. (1726 aa)

Your Current Organism:

Anser cygnoides

NCBI taxonomy Id: 8845
Other names: A. cygnoides, Chinese goose, Swan goose, white Chinese goose

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ATM	ENSACDP00005001441	ENSACDP00005004127	ATPase family AAA domain-containing protein 5 isoform X1.	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	0.540
ATAD5	MSH6	ENSACDP00005001441	ENSACDP00005017920	ATPase family AAA domain-containing protein 5 isoform X1.	DNA mismatch repair protein MSH6.	0.419
ATM	ATAD5	ENSACDP00005004127	ENSACDP00005001441	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	ATPase family AAA domain-containing protein 5 isoform X1.	0.540
ATM	MLH1	ENSACDP00005004127	ENSACDP00005007193	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	DNA mismatch repair protein Mlh1 isoform X1.	0.869
ATM	MSH2	ENSACDP00005004127	ENSACDP00005017952	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	DNA mismatch repair protein MSH2.	0.876
ATM	MSH6	ENSACDP00005004127	ENSACDP00005017920	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	DNA mismatch repair protein MSH6.	0.883
ATM	NSD2	ENSACDP00005004127	ENSACDP00005005247	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2.	0.612
ATM	PMS2	ENSACDP00005004127	ENSACDP00005011274	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	Mismatch repair endonuclease PMS2.	0.833
ATM	RIF1	ENSACDP00005004127	ENSACDP00005003919	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	Telomere-associated protein RIF1.	0.706
ATM	TP53BP1	ENSACDP00005004127	ENSACDP00005016405	LOW QUALITY PROTEIN: serine-protein kinase ATM-like.	Tumor suppressor p53-binding protein 1.	0.968
BANK1	BLK	ENSACDP00005001210	ENSACDP00005004281	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase Blk isoform X1.	0.536
BANK1	LYN	ENSACDP00005001210	ENSACDP00005022071	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase Lyn isoform X1.	0.414
BCL2	BCL6	ENSACDP00005015579	ENSACDP00005019772	BCL2 apoptosis regulator.	B-cell lymphoma 6 protein.	0.560
BCL2	ENSACDP00005016250	ENSACDP00005015579	ENSACDP00005016250	BCL2 apoptosis regulator.	annotation not available	0.610
BCL2	IL10	ENSACDP00005015579	ENSACDP00005002008	BCL2 apoptosis regulator.	Interleukin 10.	0.610
BCL2	IL6	ENSACDP00005015579	ENSACDP00005018189	BCL2 apoptosis regulator.	Interleukin 6.	0.801
BCL2	IL7	ENSACDP00005015579	ENSACDP00005000715	BCL2 apoptosis regulator.	Interleukin-7-like.	0.401
BCL2	XBP1	ENSACDP00005015579	ENSACDP00005011852	BCL2 apoptosis regulator.	X box-binding protein 1.	0.597
BCL6	BCL2	ENSACDP00005019772	ENSACDP00005015579	B-cell lymphoma 6 protein.	BCL2 apoptosis regulator.	0.560
BCL6	ENSACDP00005016250	ENSACDP00005019772	ENSACDP00005016250	B-cell lymphoma 6 protein.	annotation not available	0.444