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| | RPA2 | Replication protein A 32 kDa subunit. (270 aa) |
| | POLK | DNA polymerase kappa. (862 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa) |
| | Rad50 | DNA repair protein RAD50. (1312 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (817 aa) |
| | Mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | RFC5 | Replication factor C subunit 5. (338 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1161 aa) |
| | TDRD3 | Tudor domain-containing protein 3. (731 aa) |
| | ORC3 | Origin recognition complex subunit 3. (720 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1526 aa) |
| | RAD51D | DNA repair protein RAD51 like protein 4. (329 aa) |
| | GINS1 | DNA replication complex GINS protein PSF1. (196 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | DNA2 | DNA2-like helicase. (1059 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (967 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa) |
| | BLM | Bloom syndrome protein. (1348 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (854 aa) |
| | ENSFDAP00000003677 | annotation not available (171 aa) |
| | WDHD1 | WD repeat and HMG-box DNA-binding protein 1. (1126 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (678 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (332 aa) |
| | GMNN | Geminin. (208 aa) |
| | RAD52 | DNA repair protein RAD52 like protein. (294 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1197 aa) |
| | RHNO1 | Uncharacterized protein. (235 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1317 aa) |
| | ATAD5 | ATPase family AAA domain-containing protein 5. (1822 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa) |
| | CDT1 | DNA replication factor Cdt1. (542 aa) |
| | ATRIP | ATR-interacting protein. (720 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | ANKRD31 | Ankyrin repeat domain-containing protein 31. (1857 aa) |
| | MCM10 | Protein MCM10 like protein. (874 aa) |
| | RFC1 | Replication factor C subunit 1. (1141 aa) |
| | H920_03785 | Chromosome transmission fidelity protein 18 like protein. (125 aa) |
| | DBF4 | Protein DBF4 like protein A. (636 aa) |
| | RAD51AP1 | RAD51-associated protein 1. (335 aa) |
| | RAD51C | DNA repair protein RAD51 like protein 3. (367 aa) |
| | Msh5 | MutS protein like protein 5. (827 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa) |
| | TIMELESS | Protein timeless like protein. (1207 aa) |
| | Tm4sf19 | Transmembrane 4 L6 family member 19. (181 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase. (571 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (901 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | ENSFDAP00000010230 | annotation not available (709 aa) |
| | POLA1 | DNA polymerase. (1462 aa) |
| | RFC2 | Replication factor C subunit 2. (316 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (122 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | H920_13460 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (74 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | CLSPN | Claspin. (1338 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | Fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa) |
| | Pold4 | DNA polymerase delta subunit 4. (107 aa) |
| | RAD51B | DNA repair protein RAD51 like protein 2. (258 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1248 aa) |
| | PIEZO1 | Protein PIEZO1. (2427 aa) |
| | TP53BP1 | Tumor suppressor p53-binding protein 1. (1958 aa) |
| | DDX11 | DEAD/H-box helicase 11. (772 aa) |
| | MLH1 | DNA mismatch repair protein Mlh1. (767 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3134 aa) |
| | H920_01336 | DNA mismatch repair protein Msh3. (395 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (162 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (786 aa) |
| | DMC1 | DNA meiotic recombinase 1. (340 aa) |
| | SLF1 | Ankyrin repeat domain-containing protein 32. (1057 aa) |
| | Pms2 | PMS1 homolog 2, mismatch repair system component. (461 aa) |
| | POLI | DNA polymerase iota. (698 aa) |
| | RFC4 | Replication factor C subunit 4. (333 aa) |
| | XRCC3 | DNA repair protein XRCC3. (338 aa) |
| | Mcm8 | DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | PMS1 | PMS1 protein like protein 1. (931 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2. (549 aa) |
| | ENSFDAP00000017292 | annotation not available (27 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (672 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (147 aa) |
| | Prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | FBH1 | F-box only protein 18. (1042 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (617 aa) |
| | SASS6 | SAS-6 centriolar assembly protein. (657 aa) |
| | POLD1 | DNA polymerase delta 1, catalytic subunit. (933 aa) |
| | Pold3 | DNA polymerase delta subunit 3. (465 aa) |
| | MCM9 | DNA replication licensing factor MCM9; Belongs to the MCM family. (1106 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1439 aa) |
| | ENSFDAP00000020651 | annotation not available (191 aa) |
| | LIG1 | DNA ligase. (916 aa) |
| | MLH3 | DNA mismatch repair protein Mlh3. (1446 aa) |
| | CDC45 | Cell division control protein 45 like protein. (566 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | MRE11 | MRE11 homolog, double strand break repair nuclease. (708 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa) |
| | MEIOB | CDC24_OB3 domain-containing protein. (471 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (714 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | ORC2 | Origin recognition complex subunit 2. (599 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (469 aa) |
| | Pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | REV3L | DNA polymerase zeta catalytic subunit. (3013 aa) |
| | XRCC2 | Actin related protein 3B. (231 aa) |
| | MCMBP | Mini-chromosome maintenance complex-binding protein. (622 aa) |
