Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD31 | ATM | ENSFDAP00000007395 | ENSFDAP00000012956 | Ankyrin repeat domain-containing protein 31. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.704 |
| ANKRD31 | ATR | ENSFDAP00000007395 | ENSFDAP00000011959 | Ankyrin repeat domain-containing protein 31. | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.562 |
| ANKRD31 | BARD1 | ENSFDAP00000007395 | ENSFDAP00000018225 | Ankyrin repeat domain-containing protein 31. | BRCA1-associated RING domain protein 1. | 0.486 |
| ANKRD31 | BRCA1 | ENSFDAP00000007395 | ENSFDAP00000004478 | Ankyrin repeat domain-containing protein 31. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.987 |
| ANKRD31 | BRIP1 | ENSFDAP00000007395 | ENSFDAP00000001602 | Ankyrin repeat domain-containing protein 31. | Fanconi anemia group J protein. | 0.815 |
| ANKRD31 | CHEK2 | ENSFDAP00000007395 | ENSFDAP00000017179 | Ankyrin repeat domain-containing protein 31. | Serine/threonine-protein kinase Chk2. | 0.674 |
| ANKRD31 | MRE11 | ENSFDAP00000007395 | ENSFDAP00000021345 | Ankyrin repeat domain-containing protein 31. | MRE11 homolog, double strand break repair nuclease. | 0.945 |
| ANKRD31 | NBN | ENSFDAP00000007395 | ENSFDAP00000006798 | Ankyrin repeat domain-containing protein 31. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.940 |
| ANKRD31 | RBBP8 | ENSFDAP00000007395 | ENSFDAP00000009663 | Ankyrin repeat domain-containing protein 31. | RB binding protein 8, endonuclease. | 0.967 |
| ANKRD31 | Rad50 | ENSFDAP00000007395 | ENSFDAP00000001036 | Ankyrin repeat domain-containing protein 31. | DNA repair protein RAD50. | 0.852 |
| ANKRD31 | TOPBP1 | ENSFDAP00000007395 | ENSFDAP00000001903 | Ankyrin repeat domain-containing protein 31. | DNA topoisomerase 2-binding protein 1. | 0.945 |
| ANKRD31 | TP53BP1 | ENSFDAP00000007395 | ENSFDAP00000014604 | Ankyrin repeat domain-containing protein 31. | Tumor suppressor p53-binding protein 1. | 0.684 |
| ANKRD31 | WRN | ENSFDAP00000007395 | ENSFDAP00000020164 | Ankyrin repeat domain-containing protein 31. | Werner syndrome ATP-dependent helicase. | 0.643 |
| ATM | ANKRD31 | ENSFDAP00000012956 | ENSFDAP00000007395 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ankyrin repeat domain-containing protein 31. | 0.704 |
| ATM | ATR | ENSFDAP00000012956 | ENSFDAP00000011959 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.999 |
| ATM | BARD1 | ENSFDAP00000012956 | ENSFDAP00000018225 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA1-associated RING domain protein 1. | 0.996 |
| ATM | BRCA1 | ENSFDAP00000012956 | ENSFDAP00000004478 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.985 |
| ATM | BRIP1 | ENSFDAP00000012956 | ENSFDAP00000001602 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Fanconi anemia group J protein. | 0.785 |
| ATM | CHEK2 | ENSFDAP00000012956 | ENSFDAP00000017179 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Serine/threonine-protein kinase Chk2. | 0.992 |
| ATM | MRE11 | ENSFDAP00000012956 | ENSFDAP00000021345 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | MRE11 homolog, double strand break repair nuclease. | 0.996 |
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