(12 nodes) Mixed, incl. AP-2 adaptor complex, and Protein of unknown function (DUF1681) network (Fukomys damarensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NECAP1	Adaptin ear-binding coat-associated protein 1. (269 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (976 aa)
	AP1B1	AP-1 complex subunit beta-1. (912 aa)
	ITSN1	Intersectin-1. (1716 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (185 aa)
	Ap2b1	AP complex subunit beta. (951 aa)
	NECAP2	NECAP endocytosis associated 2. (268 aa)
	EPS15	Epidermal growth factor receptor substrate 15. (926 aa)
	AP2M1	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (435 aa)
	ITSN2	Intersectin-2. (1602 aa)
	STON2	Stonin-2; Belongs to the Stoned B family. (894 aa)
	EPS15L1	Epidermal growth factor receptor substrate 15-like 1. (795 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1B1	AP2A1	ENSFDAP00000007742	ENSFDAP00000007595	AP-1 complex subunit beta-1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.979
AP1B1	AP2M1	ENSFDAP00000007742	ENSFDAP00000018487	AP-1 complex subunit beta-1.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.988
AP1B1	AP2S1	ENSFDAP00000007742	ENSFDAP00000010366	AP-1 complex subunit beta-1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.982
AP1B1	Ap2b1	ENSFDAP00000007742	ENSFDAP00000014198	AP-1 complex subunit beta-1.	AP complex subunit beta.	0.589
AP1B1	EPS15	ENSFDAP00000007742	ENSFDAP00000018093	AP-1 complex subunit beta-1.	Epidermal growth factor receptor substrate 15.	0.816
AP1B1	EPS15L1	ENSFDAP00000007742	ENSFDAP00000022988	AP-1 complex subunit beta-1.	Epidermal growth factor receptor substrate 15-like 1.	0.816
AP1B1	ITSN1	ENSFDAP00000007742	ENSFDAP00000010299	AP-1 complex subunit beta-1.	Intersectin-1.	0.998
AP1B1	ITSN2	ENSFDAP00000007742	ENSFDAP00000020518	AP-1 complex subunit beta-1.	Intersectin-2.	0.999
AP1B1	NECAP1	ENSFDAP00000007742	ENSFDAP00000000546	AP-1 complex subunit beta-1.	Adaptin ear-binding coat-associated protein 1.	0.804
AP1B1	NECAP2	ENSFDAP00000007742	ENSFDAP00000017923	AP-1 complex subunit beta-1.	NECAP endocytosis associated 2.	0.856
AP1B1	STON2	ENSFDAP00000007742	ENSFDAP00000021253	AP-1 complex subunit beta-1.	Stonin-2; Belongs to the Stoned B family.	0.759
AP2A1	AP1B1	ENSFDAP00000007595	ENSFDAP00000007742	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-1 complex subunit beta-1.	0.979
AP2A1	AP2M1	ENSFDAP00000007595	ENSFDAP00000018487	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.999
AP2A1	AP2S1	ENSFDAP00000007595	ENSFDAP00000010366	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2A1	Ap2b1	ENSFDAP00000007595	ENSFDAP00000014198	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit beta.	0.983
AP2A1	EPS15	ENSFDAP00000007595	ENSFDAP00000018093	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Epidermal growth factor receptor substrate 15.	0.974
AP2A1	EPS15L1	ENSFDAP00000007595	ENSFDAP00000022988	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Epidermal growth factor receptor substrate 15-like 1.	0.972
AP2A1	ITSN1	ENSFDAP00000007595	ENSFDAP00000010299	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Intersectin-1.	0.994
AP2A1	ITSN2	ENSFDAP00000007595	ENSFDAP00000020518	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Intersectin-2.	0.994
AP2A1	NECAP1	ENSFDAP00000007595	ENSFDAP00000000546	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Adaptin ear-binding coat-associated protein 1.	0.908