STRINGSTRING
KDM4D KDM4D XRCC3 XRCC3 RAD21L1 RAD21L1 Mcm8 Mcm8 SWSAP1 SWSAP1 EPC1 EPC1 INO80 INO80 Sem1 Sem1 INTS3 INTS3 RAD21 RAD21 ENSFDAP00000017292 ENSFDAP00000017292 GINS4 GINS4 ENSFDAP00000017776 ENSFDAP00000017776 Slx1a Slx1a Swi5 Swi5 ZFYVE21 ZFYVE21 FBH1 FBH1 EXD2 EXD2 REC8 REC8 ENSFDAP00000019135 ENSFDAP00000019135 KAT5 KAT5 NUCKS1 NUCKS1 FANCM FANCM AUNIP AUNIP MCM9 MCM9 MBTD1 MBTD1 WRN WRN POLN POLN ZFYVE26 ZFYVE26 H920_00078 H920_00078 CDC45 CDC45 SFR1 SFR1 RAD54L RAD54L MRE11 MRE11 RPA1 RPA1 NABP1 NABP1 MEIOB MEIOB RNF138 RNF138 AP5Z1 AP5Z1 REV3L REV3L Tonsl Tonsl XRCC2 XRCC2 RAD52 RAD52 RPA2 RPA2 RECQL4 RECQL4 RAD51 RAD51 RMI2 RMI2 PPP4C PPP4C ENSFDAP00000006648 ENSFDAP00000006648 NBN NBN POLL POLL RAD51AP1 RAD51AP1 RAD51C RAD51C TOP3A TOP3A ENSFDAP00000008979 ENSFDAP00000008979 MMS22L MMS22L MUS81 MUS81 Tm4sf19 Tm4sf19 CDC7 CDC7 CCDC155 CCDC155 RBBP8 RBBP8 H920_07462 H920_07462 ENSFDAP00000010230 ENSFDAP00000010230 HELQ HELQ NIPBL NIPBL GEN1 GEN1 NSMCE1 NSMCE1 MCM2 MCM2 MCM3 MCM3 RPA3 RPA3 MCM4 MCM4 NSMCE2 NSMCE2 H2AX H2AX RECQL RECQL ATM ATM SAMHD1 SAMHD1 Rad54b Rad54b PSMD14 PSMD14 FANCB FANCB RAD51B RAD51B BRCA2 BRCA2 Spidr Spidr GINS2 GINS2 SMC6 SMC6 ENSFDAP00000015308 ENSFDAP00000015308 FAN1 FAN1 MCM6 MCM6 DMC1 DMC1 Mcm7 Mcm7 PALB2 PALB2 RAD51D RAD51D MCMDC2 MCMDC2 NABP2 NABP2 INIP INIP RECQL5 RECQL5 Yy1 Yy1 RMI1 RMI1 AP5S1 AP5S1 XRCC1 XRCC1 BLM BLM ZSWIM7 ZSWIM7 ERCC4 ERCC4 RFWD3 RFWD3 BRCA1 BRCA1 MCM5 MCM5 WDR48 WDR48 HUS1 HUS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDM4DLysine-specific demethylase 4D. (523 aa)
XRCC3DNA repair protein XRCC3. (338 aa)
RAD21L1RAD21 cohesin complex component like 1. (538 aa)
Mcm8DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa)
SWSAP1Uncharacterized protein. (281 aa)
EPC1Enhancer of polycomb homolog. (813 aa)
INO80DNA helicase INO80. (1559 aa)
Sem126S proteasome complex subunit DSS1. (70 aa)
INTS3Integrator complex subunit 3. (1045 aa)
RAD21Double-strand-break repair protein rad21 like protein. (631 aa)
ENSFDAP00000017292annotation not available (27 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
ENSFDAP00000017776annotation not available (72 aa)
Slx1aSulfotransferase; Belongs to the sulfotransferase 1 family. (63 aa)
Swi5DNA repair protein SWI5 like protein. (191 aa)
ZFYVE21Zinc finger FYVE domain-containing protein 21. (188 aa)
FBH1F-box only protein 18. (1042 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (617 aa)
REC8Meiotic recombination protein REC8 like protein. (569 aa)
ENSFDAP00000019135annotation not available (986 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (227 aa)
FANCMFanconi anemia group M protein. (1984 aa)
AUNIPUncharacterized protein. (330 aa)
MCM9DNA replication licensing factor MCM9; Belongs to the MCM family. (1106 aa)
MBTD1MBT domain-containing protein 1. (647 aa)
WRNWerner syndrome ATP-dependent helicase. (1439 aa)
POLNDNA polymerase nu. (825 aa)
ZFYVE26Zinc finger FYVE domain-containing protein 26. (2532 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
CDC45Cell division control protein 45 like protein. (566 aa)
SFR1Swi5-dependent recombination DNA repair protein 1 like protein. (224 aa)
RAD54LDNA repair and recombination protein RAD54-like. (747 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
NABP1SOSS complex subunit B2. (162 aa)
MEIOBCDC24_OB3 domain-containing protein. (471 aa)
RNF138E3 ubiquitin-protein ligase RNF138. (208 aa)
AP5Z1Protein KIAA0415. (806 aa)
REV3LDNA polymerase zeta catalytic subunit. (3013 aa)
TonslTonsoku-like protein. (64 aa)
XRCC2Actin related protein 3B. (231 aa)
RAD52DNA repair protein RAD52 like protein. (294 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
RECQL4ATP-dependent DNA helicase Q4. (1197 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RMI2RecQ mediated genome instability 2. (89 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
ENSFDAP00000006648annotation not available (129 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (572 aa)
RAD51AP1RAD51-associated protein 1. (335 aa)
RAD51CDNA repair protein RAD51 like protein 3. (367 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa)
ENSFDAP00000008979annotation not available (180 aa)
MMS22LProtein MMS22-like. (1240 aa)
MUS81Crossover junction endonuclease MUS81. (539 aa)
Tm4sf19Transmembrane 4 L6 family member 19. (181 aa)
CDC7Cell division cycle 7-related protein kinase. (571 aa)
CCDC155Coiled-coil domain-containing protein 155. (598 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
ENSFDAP00000010230annotation not available (709 aa)
HELQHelicase POLQ-like. (987 aa)
NIPBLNipped-B protein. (2804 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (869 aa)
NSMCE1Non-structural maintenance of chromosomes element 1 like protein. (266 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
MCM3DNA helicase; Belongs to the MCM family. (817 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (247 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (648 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (618 aa)
Rad54bDNA repair and recombination protein RAD54B. (908 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
FANCBFanconi anemia group B protein. (715 aa)
RAD51BDNA repair protein RAD51 like protein 2. (258 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3134 aa)
SpidrUncharacterized protein. (552 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (162 aa)
SMC6Structural maintenance of chromosomes protein 6. (1096 aa)
ENSFDAP00000015308annotation not available (503 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1021 aa)
MCM6DNA helicase; Belongs to the MCM family. (786 aa)
DMC1DNA meiotic recombinase 1. (340 aa)
Mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PALB2Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (1185 aa)
RAD51DDNA repair protein RAD51 like protein 4. (329 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
NABP2Nucleic acid binding protein 2. (227 aa)
INIPSOSS complex subunit C. (105 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (967 aa)
Yy1YY1 transcription factor. (189 aa)
RMI1RecQ-mediated genome instability protein 1. (607 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
XRCC1DNA repair protein XRCC1. (628 aa)
BLMBloom syndrome protein. (1348 aa)
ZSWIM7Zinc finger SWIM-type containing 7. (136 aa)
ERCC4DNA repair endonuclease XPF. (917 aa)
RFWD3Ring finger and WD repeat domain 3. (765 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
MCM5DNA helicase; Belongs to the MCM family. (678 aa)
WDR48WD repeat-containing protein 48. (677 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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