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KDM4D | Lysine-specific demethylase 4D. (523 aa) | ||||
XRCC3 | DNA repair protein XRCC3. (338 aa) | ||||
RAD21L1 | RAD21 cohesin complex component like 1. (538 aa) | ||||
Mcm8 | DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa) | ||||
SWSAP1 | Uncharacterized protein. (281 aa) | ||||
EPC1 | Enhancer of polycomb homolog. (813 aa) | ||||
INO80 | DNA helicase INO80. (1559 aa) | ||||
Sem1 | 26S proteasome complex subunit DSS1. (70 aa) | ||||
INTS3 | Integrator complex subunit 3. (1045 aa) | ||||
RAD21 | Double-strand-break repair protein rad21 like protein. (631 aa) | ||||
ENSFDAP00000017292 | annotation not available (27 aa) | ||||
GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) | ||||
ENSFDAP00000017776 | annotation not available (72 aa) | ||||
Slx1a | Sulfotransferase; Belongs to the sulfotransferase 1 family. (63 aa) | ||||
Swi5 | DNA repair protein SWI5 like protein. (191 aa) | ||||
ZFYVE21 | Zinc finger FYVE domain-containing protein 21. (188 aa) | ||||
FBH1 | F-box only protein 18. (1042 aa) | ||||
EXD2 | Exonuclease 3'-5' domain-containing protein 2. (617 aa) | ||||
REC8 | Meiotic recombination protein REC8 like protein. (569 aa) | ||||
ENSFDAP00000019135 | annotation not available (986 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) | ||||
NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (227 aa) | ||||
FANCM | Fanconi anemia group M protein. (1984 aa) | ||||
AUNIP | Uncharacterized protein. (330 aa) | ||||
MCM9 | DNA replication licensing factor MCM9; Belongs to the MCM family. (1106 aa) | ||||
MBTD1 | MBT domain-containing protein 1. (647 aa) | ||||
WRN | Werner syndrome ATP-dependent helicase. (1439 aa) | ||||
POLN | DNA polymerase nu. (825 aa) | ||||
ZFYVE26 | Zinc finger FYVE domain-containing protein 26. (2532 aa) | ||||
H920_00078 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa) | ||||
CDC45 | Cell division control protein 45 like protein. (566 aa) | ||||
SFR1 | Swi5-dependent recombination DNA repair protein 1 like protein. (224 aa) | ||||
RAD54L | DNA repair and recombination protein RAD54-like. (747 aa) | ||||
MRE11 | MRE11 homolog, double strand break repair nuclease. (708 aa) | ||||
RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa) | ||||
NABP1 | SOSS complex subunit B2. (162 aa) | ||||
MEIOB | CDC24_OB3 domain-containing protein. (471 aa) | ||||
RNF138 | E3 ubiquitin-protein ligase RNF138. (208 aa) | ||||
AP5Z1 | Protein KIAA0415. (806 aa) | ||||
REV3L | DNA polymerase zeta catalytic subunit. (3013 aa) | ||||
Tonsl | Tonsoku-like protein. (64 aa) | ||||
XRCC2 | Actin related protein 3B. (231 aa) | ||||
RAD52 | DNA repair protein RAD52 like protein. (294 aa) | ||||
RPA2 | Replication protein A 32 kDa subunit. (270 aa) | ||||
RECQL4 | ATP-dependent DNA helicase Q4. (1197 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
RMI2 | RecQ mediated genome instability 2. (89 aa) | ||||
PPP4C | Serine/threonine-protein phosphatase. (307 aa) | ||||
ENSFDAP00000006648 | annotation not available (129 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa) | ||||
POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (572 aa) | ||||
RAD51AP1 | RAD51-associated protein 1. (335 aa) | ||||
RAD51C | DNA repair protein RAD51 like protein 3. (367 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa) | ||||
ENSFDAP00000008979 | annotation not available (180 aa) | ||||
MMS22L | Protein MMS22-like. (1240 aa) | ||||
MUS81 | Crossover junction endonuclease MUS81. (539 aa) | ||||
Tm4sf19 | Transmembrane 4 L6 family member 19. (181 aa) | ||||
CDC7 | Cell division cycle 7-related protein kinase. (571 aa) | ||||
CCDC155 | Coiled-coil domain-containing protein 155. (598 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (901 aa) | ||||
H920_07462 | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa) | ||||
ENSFDAP00000010230 | annotation not available (709 aa) | ||||
HELQ | Helicase POLQ-like. (987 aa) | ||||
NIPBL | Nipped-B protein. (2804 aa) | ||||
GEN1 | GEN1 Holliday junction 5' flap endonuclease. (869 aa) | ||||
NSMCE1 | Non-structural maintenance of chromosomes element 1 like protein. (266 aa) | ||||
MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) | ||||
MCM3 | DNA helicase; Belongs to the MCM family. (817 aa) | ||||
RPA3 | Replication protein A 14 kDa subunit. (122 aa) | ||||
MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) | ||||
NSMCE2 | E3 SUMO-protein ligase NSE2. (247 aa) | ||||
H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) | ||||
RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (648 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa) | ||||
SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (618 aa) | ||||
Rad54b | DNA repair and recombination protein RAD54B. (908 aa) | ||||
PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) | ||||
FANCB | Fanconi anemia group B protein. (715 aa) | ||||
RAD51B | DNA repair protein RAD51 like protein 2. (258 aa) | ||||
BRCA2 | Breast cancer type 2 susceptibility protein. (3134 aa) | ||||
Spidr | Uncharacterized protein. (552 aa) | ||||
GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (162 aa) | ||||
SMC6 | Structural maintenance of chromosomes protein 6. (1096 aa) | ||||
ENSFDAP00000015308 | annotation not available (503 aa) | ||||
FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1021 aa) | ||||
MCM6 | DNA helicase; Belongs to the MCM family. (786 aa) | ||||
DMC1 | DNA meiotic recombinase 1. (340 aa) | ||||
Mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) | ||||
PALB2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (1185 aa) | ||||
RAD51D | DNA repair protein RAD51 like protein 4. (329 aa) | ||||
MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) | ||||
NABP2 | Nucleic acid binding protein 2. (227 aa) | ||||
INIP | SOSS complex subunit C. (105 aa) | ||||
RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (967 aa) | ||||
Yy1 | YY1 transcription factor. (189 aa) | ||||
RMI1 | RecQ-mediated genome instability protein 1. (607 aa) | ||||
AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) | ||||
XRCC1 | DNA repair protein XRCC1. (628 aa) | ||||
BLM | Bloom syndrome protein. (1348 aa) | ||||
ZSWIM7 | Zinc finger SWIM-type containing 7. (136 aa) | ||||
ERCC4 | DNA repair endonuclease XPF. (917 aa) | ||||
RFWD3 | Ring finger and WD repeat domain 3. (765 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa) | ||||
MCM5 | DNA helicase; Belongs to the MCM family. (678 aa) | ||||
WDR48 | WD repeat-containing protein 48. (677 aa) | ||||
HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |