STRINGSTRING
UBE2Q1 UBE2Q1 ACE2 ACE2 COMT COMT CRHBP CRHBP ARID1A ARID1A RARA RARA CTSB CTSB PLA2G6 PLA2G6 CNR1 CNR1 H920_10419 H920_10419 SLC38A2 SLC38A2 Cbs Cbs AR AR OXTR OXTR Gip Gip FOSB FOSB HSD11B2 HSD11B2 H920_14430 H920_14430 EPOR EPOR IGFBP2 IGFBP2 DEDD DEDD ANGPT2 ANGPT2 H920_19890 H920_19890 MST1 MST1 PLA2G4A PLA2G4A Itgb3 Itgb3 IGFBP5 IGFBP5 MMP2 MMP2 CDH1 CDH1 BSG BSG MTOR MTOR PTN PTN PPARD PPARD LDOC1 LDOC1 RGS2 RGS2 PGR PGR ADCY7 ADCY7 MEN1 MEN1 H920_10416 H920_10416 ADIPOR2 ADIPOR2 ITGA5 ITGA5 AGT AGT VDR VDR H920_10421 H920_10421 TGFBR2 TGFBR2 FBLN1 FBLN1 H920_16725 H920_16725 EPO EPO HPGD HPGD TEAD4 TEAD4 PTGS2 PTGS2 CSMD2 CSMD2 AKT1 AKT1 H920_10413 H920_10413 PGF PGF FUT7 FUT7 ABCC8 ABCC8 TCF23 TCF23 PAPPA PAPPA UCP2 UCP2 PRDM1 PRDM1 LEP LEP CD38 CD38 MAGED2 MAGED2 SLC38A3 SLC38A3 CYP27B1 CYP27B1 AGRP AGRP LIF LIF JUNB JUNB NODAL NODAL H920_19062 H920_19062 LOC104854599 LOC104854599 H920_10412 H920_10412 RXRB RXRB RXRA RXRA H920_03777 H920_03777 H920_10420 H920_10420 STC1 STC1 CALCA CALCA CORIN CORIN HSF1 HSF1 EXOC1 EXOC1 STS STS TPPP3 TPPP3 FKBP4 FKBP4 WNT4 WNT4 LOC104874161 LOC104874161 ENSFDAP00000009051 ENSFDAP00000009051 PCSK5 PCSK5 SLC2A1 SLC2A1 SP1 SP1 ACSL4 ACSL4 LOC104858299 LOC104858299 LOC104870649 LOC104870649 ITGA3 ITGA3 MED1 MED1 LOC104875780 LOC104875780 CRH CRH SP3 SP3 H920_04845 H920_04845 ACOD1 ACOD1 CAPN2 CAPN2 STOX2 STOX2 ENDOU ENDOU A1CF A1CF ATR ATR GHSR GHSR H920_00001 H920_00001 Stat5b Stat5b Prl Prl ATP7A ATP7A Ggn Ggn LOC104870650 LOC104870650 CTSV CTSV TGFB3 TGFB3 RECK RECK SLC38A1 SLC38A1 FOSL1 FOSL1 LOC104872504 LOC104872504 DAZAP1 DAZAP1 PRDM14 PRDM14 EMP2 EMP2 PAM PAM PRDX3 PRDX3 STC2 STC2 MAPK3 MAPK3 UMPS UMPS H920_06994 H920_06994 MAPK1 MAPK1 SOD1 SOD1 MMP9 MMP9 Trim28 Trim28 H920_10422 H920_10422 PTGIS PTGIS ITGB4 ITGB4 DDR1 DDR1 ENSFDAP00000022738 ENSFDAP00000022738 CITED2 CITED2 POLR1B POLR1B SPHK2 SPHK2 ITGA2 ITGA2 VMP1 VMP1 IHH IHH ASH1L ASH1L TMED2 TMED2 H920_06990 H920_06990 ARG1 ARG1 BMPR2 BMPR2 NDP NDP Adra2c Adra2c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (253 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (263 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
ARID1AAT-rich interactive domain-containing protein 1A. (1900 aa)
RARARetinoic acid receptor alpha. (421 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (340 aa)
PLA2G685 kDa calcium-independent phospholipase A2. (806 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
H920_10419Prolactin. (233 aa)
SLC38A2Sodium-coupled neutral amino acid transporter 2. (506 aa)
CbsCystathionine beta-synthase. (515 aa)
ARAndrogen receptor. (899 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (386 aa)
GipGastric inhibitory polypeptide. (119 aa)
FOSBProtein fosB. (340 aa)
HSD11B2Corticosteroid 11-beta-dehydrogenase isozyme 2. (387 aa)
H920_14430Histone H3.3. (187 aa)
EPORErythropoietin receptor. (378 aa)
IGFBP2Insulin-like growth factor-binding protein 2. (217 aa)
DEDDDeath effector domain-containing protein. (318 aa)
ANGPT2Angiopoietin 2. (494 aa)
H920_19890Histone H3.3 type 2. (158 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
PLA2G4APhospholipase A2. (749 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (761 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (271 aa)
MMP2Matrix metallopeptidase 2. (644 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (895 aa)
BSGBasigin. (364 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
PTNPleiotrophin. (168 aa)
PPARDPeroxisome proliferator-activated receptor delta. (440 aa)
LDOC1Protein LDOC1. (146 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
PGRProgesterone receptor. (623 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
MEN1Menin. (616 aa)
H920_10416Prolactin. (228 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (991 aa)
AGTAngiotensinogen; Belongs to the serpin family. (478 aa)
VDRVitamin D3 receptor. (419 aa)
H920_10421Prolactin. (242 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
FBLN1Fibulin 1. (705 aa)
H920_16725Histone H3.3 type 2. (201 aa)
EPOErythropoietin. (198 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD+]; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
TEAD4Transcriptional enhancer factor TEF-3. (427 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (601 aa)
CSMD2CUB and sushi domain-containing protein 2. (3540 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
H920_10413Prolactin. (150 aa)
PGFPlacental growth factor. (161 aa)
FUT7Alpha-(1,3)-fucosyltransferase. (342 aa)
ABCC8ATP-binding cassette sub-family C member 8. (1539 aa)
TCF23Transcription factor 23. (213 aa)
PAPPAPappalysin-1. (1488 aa)
UCP2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (304 aa)
PRDM1PR/SET domain 1. (849 aa)
LEPLeptin. (167 aa)
CD38ADP-ribosyl cyclase 1. (307 aa)
MAGED2Melanoma-associated antigen D2. (606 aa)
SLC38A3Sodium-coupled neutral amino acid transporter 3. (503 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (509 aa)
AGRPAgouti-related protein. (132 aa)
LIFLeukemia inhibitory factor. (202 aa)
JUNBTranscription factor jun-B. (257 aa)
NODALNodal growth differentiation factor. (322 aa)
H920_19062Protein FAM127A. (114 aa)
LOC104854599Histone H3; Belongs to the histone H3 family. (136 aa)
H920_10412Prolactin. (172 aa)
RXRBRetinoic acid receptor RXR-beta. (486 aa)
RXRARetinoid X receptor alpha. (464 aa)
H920_03777Serine protease 29; Belongs to the peptidase S1 family. (514 aa)
H920_10420Prolactin-7D1. (210 aa)
STC1Stanniocalcin-1. (247 aa)
CALCACalcitonin gene-related peptide 2. (140 aa)
CORINCorin, serine peptidase. (997 aa)
HSF1Heat shock factor protein 1. (504 aa)
EXOC1Exocyst complex component 1. (901 aa)
STSSteryl-sulfatase. (666 aa)
TPPP3Tubulin polymerization-promoting protein family member 3. (176 aa)
FKBP4Peptidylprolyl isomerase. (424 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (327 aa)
LOC104874161CUB and zona pellucida-like domain-containing protein 1. (456 aa)
ENSFDAP00000009051annotation not available (385 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5. (1852 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (494 aa)
SP1Transcription factor Sp1. (784 aa)
ACSL4Long-chain-fatty-acid--CoA ligase 4. (711 aa)
LOC104858299Histone H3.3. (136 aa)
LOC104870649Prolactin. (155 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (1000 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1568 aa)
LOC104875780Histone H3.3. (124 aa)
CRHCorticoliberin. (194 aa)
SP3Transcription factor Sp3. (689 aa)
H920_04845Histone H3.3 type 2. (102 aa)
ACOD1Immune-responsive gene 1 protein. (468 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (597 aa)
STOX2Storkhead-box protein 2. (926 aa)
ENDOUPoly(U)-specific endoribonuclease. (411 aa)
A1CFAPOBEC1 complementation factor. (587 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
H920_00001Protein FAM127A. (114 aa)
Stat5bSignal transducer and activator of transcription 5B. (736 aa)
PrlProlactin. (222 aa)
ATP7ACopper-transporting ATPase 1. (1500 aa)
GgnGametogenetin. (131 aa)
LOC104870650Prolactin. (105 aa)
CTSVCathepsin L1; Belongs to the peptidase C1 family. (334 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RECKReversion-inducing cysteine-rich protein with Kazal motifs. (936 aa)
SLC38A1Sodium-coupled neutral amino acid transporter 1. (486 aa)
FOSL1Fos-related antigen 1. (241 aa)
LOC104872504Histone H3.3. (136 aa)
DAZAP1DAZ-associated protein 1. (403 aa)
PRDM14PR domain zinc finger protein 14. (581 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (166 aa)
PAMPeptidyl-glycine alpha-amidating monooxygenase. (961 aa)
PRDX3Thioredoxin-dependent peroxide reductase, mitochondrial. (257 aa)
STC2Stanniocalcin-2. (294 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
UMPSUridine 5'-monophosphate synthase. (480 aa)
H920_06994Natriuretic peptide A. (244 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (138 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
Trim28Transcription intermediary factor 1-beta. (719 aa)
H920_10422Prolactin-7D1. (116 aa)
PTGISProstacyclin synthase; Belongs to the cytochrome P450 family. (466 aa)
ITGB4Integrin beta. (1761 aa)
DDR1Tyrosine-protein kinase receptor. (916 aa)
ENSFDAP00000022738annotation not available (124 aa)
CITED2Cbp/p300-interacting transactivator 2. (220 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
SPHK2Sphingosine kinase 2. (653 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
VMP1Vacuole membrane protein 1. (405 aa)
IHHIndian hedgehog signaling molecule. (370 aa)
ASH1LPutative histone-lysine N-methyltransferase ASH1L. (2961 aa)
TMED2Transmembrane p24 trafficking protein 2. (116 aa)
H920_06990Transcription intermediary factor 1-beta. (810 aa)
ARG1Arginase. (323 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1025 aa)
NDPNorrin. (133 aa)
Adra2cAdrenoceptor alpha 2C. (230 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
Server load: low (12%) [HD]