50 items (Fukomys damarensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Ikbke	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (130 aa)
	FTO	Alpha-ketoglutarate-dependent dioxygenase FTO. (498 aa)
	PLIN3	Perilipin-3. (348 aa)
	EHD1	EH domain-containing protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
	LOC104872673	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (545 aa)
	VSTM2B	V-set and transmembrane domain containing 2B. (178 aa)
	ASXL2	Putative Polycomb group protein ASXL2. (1406 aa)
	H920_04941	Apolipoprotein C-IV. (97 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (389 aa)
	NR1H2	Oxysterols receptor LXR-beta. (368 aa)
	LOC104848797	Tetratricopeptide repeat protein 39B. (605 aa)
	H920_05631	V-set and transmembrane domain-containing protein 2A. (159 aa)
	SIRT1	NAD-dependent deacetylase sirtuin-1. (603 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (890 aa)
	PPARD	Peroxisome proliferator-activated receptor delta. (440 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (337 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (224 aa)
	Itgb3	Integrin beta; Belongs to the integrin beta chain family. (761 aa)
	C3	Complement C3. (1489 aa)
	CPT1A	Carnitine O-palmitoyltransferase 1, liver isoform. (772 aa)
	ABCG1	ATP-binding cassette sub-family G member 1. (618 aa)
	LOC104860587	Liver carboxylesterase 22. (314 aa)
	OSBPL11	Oxysterol binding protein like 11. (714 aa)
	Pla2g10	Phospholipase A(2). (215 aa)
	PNPLA2	Patatin-like phospholipase domain-containing protein 2. (429 aa)
	FITM1	Fat storage-inducing transmembrane protein 1. (292 aa)
	SREBF1	Sterol regulatory element-binding protein 1. (1151 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (231 aa)
	ACACB	Acetyl-CoA carboxylase 2. (2409 aa)
	LOC104860586	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	LOC104872961	Allergen Fel d 4; Belongs to the calycin superfamily. Lipocalin family. (283 aa)
	TTC39B	Tetratricopeptide repeat protein 39B. (604 aa)
	ITGAV	Integrin alpha-V; Belongs to the integrin alpha chain family. (996 aa)
	ZC3H12A	Ribonuclease ZC3H12A. (595 aa)
	ABHD5	1-acylglycerol-3-phosphate O-acyltransferase ABHD5. (333 aa)
	NR1H3	Oxysterols receptor LXR-alpha. (443 aa)
	CD36	Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
	ALKBH7	Putative alpha-ketoglutarate-dependent dioxygenase ABH7. (218 aa)
	TTC39A	Tetratricopeptide repeat protein 39A. (578 aa)
	APOB	Apolipoprotein B-100. (4381 aa)
	MEST	Mesoderm-specific transcript like protein. (335 aa)
	LEP	Leptin. (167 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1120 aa)
	FITM2	Fat storage-inducing transmembrane protein 2. (261 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (502 aa)
	HILPDA	Hypoxia-inducible gene 2 protein. (64 aa)
	SLC35F5	Solute carrier family 35 member F5. (509 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG1	NR1H2	ENSFDAP00000014886	ENSFDAP00000018789	ATP-binding cassette sub-family G member 1.	Oxysterols receptor LXR-beta.	0.610
ABCG1	NR1H3	ENSFDAP00000014886	ENSFDAP00000006253	ATP-binding cassette sub-family G member 1.	Oxysterols receptor LXR-alpha.	0.620
ABCG1	PPARG	ENSFDAP00000014886	ENSFDAP00000016315	ATP-binding cassette sub-family G member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.520
ABCG1	SCARB1	ENSFDAP00000014886	ENSFDAP00000003094	ATP-binding cassette sub-family G member 1.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.546
ABCG1	SREBF1	ENSFDAP00000014886	ENSFDAP00000012623	ATP-binding cassette sub-family G member 1.	Sterol regulatory element-binding protein 1.	0.477
ABCG1	SREBF2	ENSFDAP00000014886	ENSFDAP00000004062	ATP-binding cassette sub-family G member 1.	Sterol regulatory element binding transcription factor 2.	0.566
ABHD5	ACACB	ENSFDAP00000006952	ENSFDAP00000009817	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	Acetyl-CoA carboxylase 2.	0.433
ABHD5	APOB	ENSFDAP00000006952	ENSFDAP00000005130	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	Apolipoprotein B-100.	0.475
ABHD5	LPL	ENSFDAP00000006952	ENSFDAP00000004125	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.443
ABHD5	PLIN2	ENSFDAP00000006952	ENSFDAP00000016570	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	Perilipin; Belongs to the perilipin family.	0.845
ABHD5	PLIN3	ENSFDAP00000006952	ENSFDAP00000022016	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	Perilipin-3.	0.896
ABHD5	PNPLA2	ENSFDAP00000006952	ENSFDAP00000013604	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	Patatin-like phospholipase domain-containing protein 2.	0.975
ACACB	ABHD5	ENSFDAP00000009817	ENSFDAP00000006952	Acetyl-CoA carboxylase 2.	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	0.433
ACACB	CPT1A	ENSFDAP00000009817	ENSFDAP00000015047	Acetyl-CoA carboxylase 2.	Carnitine O-palmitoyltransferase 1, liver isoform.	0.952
ACACB	SREBF1	ENSFDAP00000009817	ENSFDAP00000012623	Acetyl-CoA carboxylase 2.	Sterol regulatory element-binding protein 1.	0.656
ACACB	SREBF2	ENSFDAP00000009817	ENSFDAP00000004062	Acetyl-CoA carboxylase 2.	Sterol regulatory element binding transcription factor 2.	0.534
ALKBH7	FTO	ENSFDAP00000006129	ENSFDAP00000022385	Putative alpha-ketoglutarate-dependent dioxygenase ABH7.	Alpha-ketoglutarate-dependent dioxygenase FTO.	0.737
APOB	ABHD5	ENSFDAP00000005130	ENSFDAP00000006952	Apolipoprotein B-100.	1-acylglycerol-3-phosphate O-acyltransferase ABHD5.	0.475
APOB	CD36	ENSFDAP00000005130	ENSFDAP00000006136	Apolipoprotein B-100.	Platelet glycoprotein 4; Belongs to the CD36 family.	0.903
APOB	H920_04941	ENSFDAP00000005130	ENSFDAP00000019955	Apolipoprotein B-100.	Apolipoprotein C-IV.	0.670