STRINGSTRING
UBE2E1 UBE2E1 LEO1 LEO1 SKP1 SKP1 Phc1 Phc1 RNF168 RNF168 ENSFDAP00000019096 ENSFDAP00000019096 ENSFDAP00000018895 ENSFDAP00000018895 PCGF1 PCGF1 PAF1 PAF1 H920_15675 H920_15675 ENSFDAP00000017776 ENSFDAP00000017776 DDB2 DDB2 USP22 USP22 DDB1 DDB1 ENSFDAP00000015814 ENSFDAP00000015814 H920_20354 H920_20354 Bmi1 Bmi1 ENSFDAP00000013479 ENSFDAP00000013479 H920_07431 H920_07431 PCGF3 PCGF3 PCGF5 PCGF5 Wac Wac BCOR BCOR RNF8 RNF8 CUL4B CUL4B RING1 RING1 CBX8 CBX8 H920_07462 H920_07462 RNF20 RNF20 Ube2b Ube2b H920_15122 H920_15122 TRIM37 TRIM37 CDC73 CDC73 ENSFDAP00000006648 ENSFDAP00000006648 Rnf2 Rnf2 RNF40 RNF40 ENSFDAP00000006015 ENSFDAP00000006015 UBE2A UBE2A DTX3L DTX3L PCGF6 PCGF6 RAG1 RAG1 RYBP RYBP UBR2 UBR2 PCGF2 PCGF2 SUZ12 SUZ12 UHRF1 UHRF1 ATXN7L3 ATXN7L3 CTR9 CTR9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2E1Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
LEO1RNA polymerase-associated protein LEO1. (634 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (188 aa)
Phc1Polyhomeotic-like protein 1. (79 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa)
ENSFDAP00000019096annotation not available (641 aa)
ENSFDAP00000018895annotation not available (308 aa)
PCGF1Polycomb group RING finger protein 1. (259 aa)
PAF1RNA polymerase II-associated factor 1 like protein. (534 aa)
H920_15675S-phase kinase-associated protein 1; Belongs to the SKP1 family. (135 aa)
ENSFDAP00000017776annotation not available (72 aa)
DDB2DNA damage-binding protein 2. (296 aa)
USP22Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (468 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
ENSFDAP00000015814annotation not available (154 aa)
H920_20354S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
Bmi1Polycomb complex protein BMI-1. (326 aa)
ENSFDAP00000013479annotation not available (466 aa)
H920_07431S-phase kinase-associated protein 1; Belongs to the SKP1 family. (136 aa)
PCGF3Polycomb group RING finger protein 3. (241 aa)
PCGF5Polycomb group RING finger protein 5. (255 aa)
WacWW domain-containing adapter protein with coiled-coil. (620 aa)
BCORBCL-6 corepressor. (1761 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
CUL4BCullin-4B; Belongs to the cullin family. (888 aa)
RING1Ring finger protein 1. (404 aa)
CBX8Chromobox protein like protein 8. (365 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
Ube2bUbiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (137 aa)
H920_15122Lysine-specific demethylase 2B. (703 aa)
TRIM37E3 ubiquitin-protein ligase TRIM37. (982 aa)
CDC73Parafibromin. (531 aa)
ENSFDAP00000006648annotation not available (129 aa)
Rnf2E3 ubiquitin-protein ligase RING2. (336 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
ENSFDAP00000006015annotation not available (149 aa)
UBE2AUbiquitin-conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (224 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (738 aa)
PCGF6Polycomb group RING finger protein 6. (230 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1042 aa)
RYBPRING1 and YY1-binding protein. (224 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1735 aa)
PCGF2Polycomb group RING finger protein 2. (344 aa)
SUZ12Polycomb protein SUZ12. (659 aa)
UHRF1E3 ubiquitin-protein ligase UHRF1. (780 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (334 aa)
CTR9RNA polymerase-associated protein CTR9 like protein. (1175 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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