STRINGSTRING
MCF2L MCF2L CDC42BPB CDC42BPB SPEF1 SPEF1 ABI2 ABI2 DNM2 DNM2 ARHGEF7 ARHGEF7 CCDC88A CCDC88A TWF2 TWF2 ARHGAP31 ARHGAP31 SLC39A6 SLC39A6 ITGB1BP1 ITGB1BP1 ENSFDAP00000001033 ENSFDAP00000001033 PTPRM PTPRM CORO1C CORO1C ENAH ENAH MYH10 MYH10 CTTN CTTN CTNNA1 CTNNA1 PLD1 PLD1 VAMP7 VAMP7 FLOT2 FLOT2 APC APC ROCK1 ROCK1 APBB1 APBB1 PXN PXN APC2 APC2 BCAR1 BCAR1 LOC104854732 LOC104854732 RDX RDX Srgap2 Srgap2 FAP FAP Ajuba Ajuba TRPV4 TRPV4 TRPV2 TRPV2 AVIL AVIL CORO6 CORO6 CTNND1 CTNND1 SORBS2 SORBS2 RAC1 RAC1 NCKAP1 NCKAP1 STMN2 STMN2 DAG1 DAG1 AMOTL1 AMOTL1 TESK1 TESK1 KCNA2 KCNA2 MYO10 MYO10 UNC5C UNC5C Rab13 Rab13 FSCN3 FSCN3 PKN2 PKN2 ENSFDAP00000005651 ENSFDAP00000005651 ACTA2 ACTA2 ACTC1 ACTC1 DBNL DBNL TSC1 TSC1 DUSP22 DUSP22 ENSFDAP00000006459 ENSFDAP00000006459 PARVB PARVB PTPRZ1 PTPRZ1 CIB1 CIB1 CAPRIN1 CAPRIN1 Ppp1r9b Ppp1r9b RUFY3 RUFY3 PDLIM4 PDLIM4 ITGAV ITGAV INPPL1 INPPL1 GIT1 GIT1 DGKZ DGKZ ABLIM3 ABLIM3 DYNLT1 DYNLT1 DYSF DYSF PLEKHH2 PLEKHH2 KPTN KPTN GDPD2 GDPD2 PHACTR4 PHACTR4 Pdxp Pdxp P4HB P4HB PARVA PARVA FSCN1 FSCN1 WASF3 WASF3 ABI3BP ABI3BP PAK1 PAK1 CARMIL1 CARMIL1 ENSFDAP00000008900 ENSFDAP00000008900 ALS2 ALS2 EVL EVL ABLIM1 ABLIM1 ACTG2 ACTG2 IGF2BP1 IGF2BP1 PIP5K1A PIP5K1A GSN GSN MTSS2 MTSS2 MYLK MYLK ITSN1 ITSN1 Fam89b Fam89b SRCIN1 SRCIN1 CIB3 CIB3 KITLG KITLG DPP4 DPP4 CAPG CAPG ACTA1 ACTA1 WASF2 WASF2 FAT1 FAT1 DBN1 DBN1 MEFV MEFV BRK1 BRK1 CARMIL2 CARMIL2 CTNNA3 CTNNA3 ARHGEF6 ARHGEF6 SCYL3 SCYL3 CYFIP1 CYFIP1 Actb Actb Snx2 Snx2 CD44 CD44 H920_09656 H920_09656 ACTR2 ACTR2 STX2 STX2 H920_12193 H920_12193 MYO9B MYO9B ANTXR1 ANTXR1 SNX1 SNX1 Spata13 Spata13 ILK ILK FGD4 FGD4 FGD1 FGD1 SHTN1 SHTN1 RAPGEF3 RAPGEF3 PPP1R9A PPP1R9A Wasf1 Wasf1 BAIAP2 BAIAP2 ENSFDAP00000014712 ENSFDAP00000014712 CLRN1 CLRN1 H920_04111 H920_04111 PLD2 PLD2 NF2 NF2 STX3 STX3 PTK2B PTK2B LIMK1 LIMK1 ENSFDAP00000015841 ENSFDAP00000015841 Itgb3 Itgb3 LOC104855452 LOC104855452 STX4 STX4 PLEKHG5 PLEKHG5 Cdc42 Cdc42 ACTR3 ACTR3 CORO1A CORO1A CDH1 CDH1 ENSFDAP00000016516 ENSFDAP00000016516 LOC104862371 LOC104862371 IQGAP2 IQGAP2 PLXND1 PLXND1 PALLD PALLD Cdk5 Cdk5 CDH2 CDH2 PTPN13 PTPN13 CTNNA2 CTNNA2 H920_19642 H920_19642 RAC2 RAC2 PTK2 PTK2 Rab3ip Rab3ip CARMIL3 CARMIL3 STXBP2 STXBP2 VIL1 VIL1 DMD DMD LOC104851452 LOC104851452 AMOT AMOT Ctnnb1 Ctnnb1 Arpc5 Arpc5 LOC104867799 LOC104867799 ENSFDAP00000019408 ENSFDAP00000019408 ARPC2 ARPC2 PIK3CA PIK3CA CSPG4 CSPG4 PLCG1 PLCG1 CAPZB CAPZB FLOT1 FLOT1 HAX1 HAX1 EPHA2 EPHA2 CORO1B CORO1B PLCE1 PLCE1 ENSFDAP00000021627 ENSFDAP00000021627 ARPC3 ARPC3 ITGB1 ITGB1 H920_14496 H920_14496 Sh3bp1 Sh3bp1 ABITRAM ABITRAM ABI1 ABI1 SH3RF1 SH3RF1 LOC104860070 LOC104860070 PKD2 PKD2 WASL WASL STMN4 STMN4 KLHL2 KLHL2 DPYSL3 DPYSL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCF2LGuanine nucleotide exchange factor DBS. (1121 aa)
CDC42BPBSerine/threonine-protein kinase MRCK beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1586 aa)
SPEF1Sperm flagellar protein 1. (236 aa)
ABI2Abl interactor 2. (447 aa)
DNM2Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (809 aa)
CCDC88AGirdin. (1872 aa)
TWF2Twinfilin-2. (351 aa)
ARHGAP31Rho GTPase-activating protein 31. (1492 aa)
SLC39A6Zinc transporter ZIP6. (732 aa)
ITGB1BP1Integrin beta-1-binding protein 1. (200 aa)
ENSFDAP00000001033annotation not available (269 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu. (1457 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
ENAHENAH actin regulator. (810 aa)
MYH10Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
CTTNSrc substrate cortactin. (548 aa)
CTNNA1Catenin alpha-1. (906 aa)
PLD1Phospholipase. (1080 aa)
VAMP7Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (412 aa)
APCAdenomatous polyposis coli protein. (2857 aa)
ROCK1Rho-associated protein kinase 1; Belongs to the peptidase C19 family. (1368 aa)
APBB1Amyloid beta A4 protein-binding family B member 1. (709 aa)
PXNPaxillin. (585 aa)
APC2Adenomatous polyposis coli protein 2. (1982 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (870 aa)
LOC104854732Uncharacterized protein. (472 aa)
RDXRadixin. (583 aa)
Srgap2SLIT-ROBO Rho GTPase-activating protein 2. (1070 aa)
FAPSeprase; Belongs to the peptidase S9B family. (759 aa)
AjubaProtein ajuba. (121 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (745 aa)
AVILVillin-1. (819 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (472 aa)
CTNND1Catenin delta-1. (937 aa)
SORBS2Sorbin and SH3 domain-containing protein 2. (1215 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (199 aa)
NCKAP1Nck-associated protein 1. (1098 aa)
STMN2Stathmin-2. (179 aa)
DAG1Dystroglycan. (893 aa)
AMOTL1Angiomotin-like protein 1. (962 aa)
TESK1Dual specificity testis-specific protein kinase 1. (588 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
MYO10Myosin-X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1844 aa)
UNC5CNetrin receptor UNC5C. (908 aa)
Rab13RAB13, member RAS oncogene family. (132 aa)
FSCN3Fascin. (498 aa)
PKN2Serine/threonine-protein kinase N2. (967 aa)
ENSFDAP00000005651annotation not available (195 aa)
ACTA2Actin, aortic smooth muscle. (377 aa)
ACTC1Actin, alpha cardiac muscle 1. (377 aa)
DBNLDrebrin-like protein. (414 aa)
TSC1Hamartin. (1168 aa)
DUSP22Dual specificity protein phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (197 aa)
ENSFDAP00000006459annotation not available (432 aa)
PARVBParvin beta. (326 aa)
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta. (1460 aa)
CIB1Calcium and integrin-binding protein 1. (174 aa)
CAPRIN1Caprin-1. (690 aa)
Ppp1r9bNeurabin-2. (365 aa)
RUFY3Protein RUFY3. (536 aa)
PDLIM4PDZ and LIM domain 4. (312 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (996 aa)
INPPL1Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. (1225 aa)
GIT1ARF GTPase-activating protein GIT1. (770 aa)
DGKZDiacylglycerol kinase zeta. (998 aa)
ABLIM3Actin-binding LIM protein 3. (683 aa)
DYNLT1Dynein light chain Tctex-type 1. (113 aa)
DYSFDysferlin. (2120 aa)
PLEKHH2Pleckstrin homology domain-containing family H member 2. (1500 aa)
KPTNKaptin. (435 aa)
GDPD2Glycerophosphoinositol inositolphosphodiesterase GDPD2. (540 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
PdxpPyridoxal phosphate phosphatase. (79 aa)
P4HBProtein disulfide-isomerase. (509 aa)
PARVAAlpha-parvin. (372 aa)
FSCN1Fascin. (477 aa)
WASF3Wiskott-Aldrich syndrome protein family member 3. (502 aa)
ABI3BPABI family member 3 binding protein. (1176 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
CARMIL1Leucine-rich repeat-containing protein 16A. (1363 aa)
ENSFDAP00000008900annotation not available (172 aa)
ALS2Alsin. (1647 aa)
EVLEna/VASP-like protein. (399 aa)
ABLIM1Actin-binding LIM protein 1. (859 aa)
ACTG2Actin, gamma-enteric smooth muscle. (723 aa)
IGF2BP1Insulin-like growth factor 2 mRNA-binding protein 1. (470 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type-1 alpha. (548 aa)
GSNGelsolin. (776 aa)
MTSS2MTSS I-BAR domain containing 2. (653 aa)
MYLKMyosin light chain kinase, smooth muscle. (1926 aa)
ITSN1Intersectin-1. (1716 aa)
Fam89bFamily with sequence similarity 89 member B. (93 aa)
SRCIN1SRC kinase signaling inhibitor 1. (855 aa)
CIB3Calcium and integrin-binding family member 3. (160 aa)
KITLGKit ligand. (272 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (764 aa)
CAPGMacrophage-capping protein. (349 aa)
ACTA1Actin, alpha skeletal muscle. (377 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2. (485 aa)
FAT1Protocadherin Fat 1. (4623 aa)
DBN1Drebrin. (682 aa)
MEFVPyrin. (828 aa)
BRK1Protein BRICK1. (95 aa)
CARMIL2Leucine-rich repeat-containing protein 16C. (1327 aa)
CTNNA3Catenin alpha-3. (895 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6. (789 aa)
SCYL3Protein-associating with the carboxyl-terminal domain of ezrin. (743 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1233 aa)
ActbActin, cytoplasmic 1. (375 aa)
Snx2Sorting nexin-2. (483 aa)
CD44CD44 antigen. (695 aa)
H920_09656Catenin beta-1. (83 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
STX2Syntaxin-2; Belongs to the syntaxin family. (279 aa)
H920_12193Actin, cytoplasmic type 8; Belongs to the actin family. (187 aa)
MYO9BMyosin IXB. (1632 aa)
ANTXR1ANTXR cell adhesion molecule 1. (556 aa)
SNX1Sorting nexin-1. (521 aa)
Spata13Spermatogenesis-associated protein 13. (574 aa)
ILKIntegrin-linked protein kinase. (452 aa)
FGD4FYVE, RhoGEF and PH domain-containing protein 4. (769 aa)
FGD1FYVE, RhoGEF and PH domain-containing protein 1. (934 aa)
SHTN1Shootin 1. (611 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
PPP1R9ANeurabin-1. (1285 aa)
Wasf1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2. (536 aa)
ENSFDAP00000014712annotation not available (471 aa)
CLRN1Protein FAM188B2. (232 aa)
H920_04111Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (130 aa)
PLD2Phospholipase D2. (936 aa)
NF2Merlin. (596 aa)
STX3Syntaxin-3; Belongs to the syntaxin family. (281 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LIMK1LIM domain kinase 1. (631 aa)
ENSFDAP00000015841annotation not available (232 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (761 aa)
LOC104855452Wiskott-Aldrich syndrome protein family member 1. (379 aa)
STX4Syntaxin-4; Belongs to the syntaxin family. (298 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1028 aa)
Cdc42Cell division control protein 42 like protein. (191 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (391 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (895 aa)
ENSFDAP00000016516annotation not available (156 aa)
LOC104862371Tumor necrosis factor receptor superfamily member 16. (231 aa)
IQGAP2Ras GTPase-activating-like protein IQGAP2. (1559 aa)
PLXND1Plexin-D1. (1422 aa)
PALLDPalladin. (903 aa)
Cdk5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CDH2Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
PTPN13Tyrosine-protein phosphatase non-receptor type 13. (2437 aa)
CTNNA2Catenin alpha-2. (954 aa)
H920_19642Vasodilator-stimulated phosphoprotein. (108 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
Rab3ipRab-3A-interacting protein. (428 aa)
CARMIL3Leucine-rich repeat-containing protein 16B. (1374 aa)
STXBP2Syntaxin binding protein 2. (574 aa)
VIL1Villin-1. (827 aa)
DMDDystrophin. (3679 aa)
LOC104851452Tyrosine-protein kinase Fer. (554 aa)
AMOTAngiomotin. (1069 aa)
Ctnnb1Catenin beta-1. (781 aa)
Arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
LOC104867799Tyrosine-protein kinase Fer. (265 aa)
ENSFDAP00000019408annotation not available (489 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2321 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
FLOT1Flotillin 1. (380 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (224 aa)
EPHA2Ephrin type-A receptor 2. (947 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (486 aa)
PLCE1Phosphoinositide phospholipase C. (2298 aa)
ENSFDAP00000021627annotation not available (136 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (803 aa)
H920_14496Nesprin-2. (661 aa)
Sh3bp1SH3 domain-binding protein 1. (692 aa)
ABITRAMUncharacterized protein. (198 aa)
ABI1Abl interactor 1. (470 aa)
SH3RF1Putative E3 ubiquitin-protein ligase SH3RF1. (888 aa)
LOC104860070Uncharacterized protein. (226 aa)
PKD2Polycystin-2. (779 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (504 aa)
STMN4Stathmin-4. (216 aa)
KLHL2Kelch-like protein 2. (584 aa)
DPYSL3Dihydropyrimidinase-related protein 3. (683 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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