STRINGSTRING
SMCHD1 SMCHD1 INIP INIP NABP2 NABP2 ENSFDAP00000001872 ENSFDAP00000001872 Rad50 Rad50 HUS1 HUS1 SIRT7 SIRT7 RPA2 RPA2 TP53BP1 TP53BP1 CYREN CYREN SHLD2 SHLD2 SAMHD1 SAMHD1 ACTR2 ACTR2 LOC104851526 LOC104851526 HELB HELB H2AX H2AX TP53 TP53 RPA3 RPA3 RNF8 RNF8 H920_12355 H920_12355 RNF169 RNF169 PARP1 PARP1 RBBP8 RBBP8 PARP3 PARP3 Vcp Vcp RIF1 RIF1 TIMELESS TIMELESS SMARCAD1 SMARCAD1 APLF APLF POLL POLL PAXX PAXX NBN NBN RAD51 RAD51 ESCO2 ESCO2 SHLD1 SHLD1 PHF1 PHF1 WAS WAS LMNA LMNA RFWD3 RFWD3 ARPC1A ARPC1A CNTD1 CNTD1 WDR70 WDR70 SLF2 SLF2 Tonsl Tonsl RNF138 RNF138 ENSFDAP00000021627 ENSFDAP00000021627 NABP1 NABP1 MRE11 MRE11 UFL1 UFL1 H920_19720 H920_19720 RNF168 RNF168 WRAP53 WRAP53 ARPC2 ARPC2 Arpc5 Arpc5 ATF2 ATF2 PRPF19 PRPF19 ENSFDAP00000018569 ENSFDAP00000018569 RAD18 RAD18 FAM178B FAM178B SMARCAL1 SMARCAL1 Iffo1 Iffo1 ENSFDAP00000017585 ENSFDAP00000017585 INTS3 INTS3 NHEJ1 NHEJ1 DDB1 DDB1 ACTR3 ACTR3 KDM4D KDM4D SLF1 SLF1 POLH POLH XRCC4 XRCC4 SMC6 SMC6 H920_04111 H920_04111
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1920 aa)
INIPSOSS complex subunit C. (105 aa)
NABP2Nucleic acid binding protein 2. (227 aa)
ENSFDAP00000001872annotation not available (356 aa)
Rad50DNA repair protein RAD50. (1312 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
SIRT7NAD-dependent deacetylase sirtuin-7. (400 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1958 aa)
CYRENCell cycle regulator of NHEJ. (166 aa)
SHLD2Protein FAM35A. (888 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (618 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
LOC104851526Histone-lysine N-methyltransferase SETMAR. (299 aa)
HELBDNA helicase B. (993 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
H920_12355Bifunctional polynucleotide phosphatase/kinase. (173 aa)
RNF169RING finger protein 169. (609 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
VcpTransitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (800 aa)
RIF1Replication timing regulatory factor 1. (2455 aa)
TIMELESSProtein timeless like protein. (1207 aa)
SMARCAD1annotation not available (1025 aa)
APLFAprataxin and PNK-like factor. (544 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (572 aa)
PAXXPAXX non-homologous end joining factor. (202 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ESCO2N-acetyltransferase ESCO2. (605 aa)
SHLD1Shieldin complex subunit 1. (203 aa)
PHF1PHD finger protein 1. (573 aa)
WASWASP actin nucleation promoting factor. (420 aa)
LMNAPrelamin-A/C; Belongs to the intermediate filament family. (453 aa)
RFWD3Ring finger and WD repeat domain 3. (765 aa)
ARPC1AActin-related protein 2/3 complex subunit 1A. (370 aa)
CNTD1Cyclin N-terminal domain-containing protein 1. (322 aa)
WDR70WD repeat-containing protein 70. (652 aa)
SLF2Protein FAM178A. (1168 aa)
TonslTonsoku-like protein. (64 aa)
RNF138E3 ubiquitin-protein ligase RNF138. (208 aa)
ENSFDAP00000021627annotation not available (136 aa)
NABP1SOSS complex subunit B2. (162 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
UFL1E3 UFM1-protein ligase 1. (791 aa)
H920_19720Actin-related protein 2/3 complex subunit 1A. (254 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa)
WRAP53Telomerase Cajal body protein 1. (507 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
Arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
PRPF19Pre-mRNA-processing factor 19. (440 aa)
ENSFDAP00000018569annotation not available (445 aa)
RAD18E3 ubiquitin-protein ligase RAD18. (501 aa)
FAM178BFamily with sequence similarity 178 member B. (513 aa)
SMARCAL1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1. (907 aa)
Iffo1Putative ribosomal RNA methyltransferase NOP2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (271 aa)
ENSFDAP00000017585annotation not available (320 aa)
INTS3Integrator complex subunit 3. (1045 aa)
NHEJ1Non-homologous end-joining factor 1. (299 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
KDM4DLysine-specific demethylase 4D. (523 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1057 aa)
POLHDNA polymerase eta. (709 aa)
XRCC4DNA repair protein XRCC4. (333 aa)
SMC6Structural maintenance of chromosomes protein 6. (1096 aa)
H920_04111Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (130 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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