(79 nodes) Positive regulation of T cell proliferation network (Fukomys damarensis)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PTPRC	Receptor-type tyrosine-protein phosphatase C. (1146 aa)
	ENSFDAP00000022477	annotation not available (326 aa)
	ITGAL	Integrin alpha-L; Belongs to the integrin alpha chain family. (1138 aa)
	TNFRSF13C	TNF receptor superfamily member 13C. (177 aa)
	NCKAP1L	Nck-associated protein 1-like. (1133 aa)
	H920_05445	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (499 aa)
	CCDC88B	Coiled-coil domain containing 88B. (1471 aa)
	AGER	Advanced glycosylation end product-specific receptor. (418 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	Zp3	Zona pellucida glycoprotein 3. (427 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2. (482 aa)
	Il1b	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	DNAJA3	DnaJ like protein subfamily A member 3, mitochondrial. (478 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	VTCN1	V-set domain-containing T-cell activation inhibitor 1. (282 aa)
	Pycard	Apoptosis-associated speck-like protein containing a CARD. (122 aa)
	CD81	Tetraspanin. (214 aa)
	NCK2	Cytoplasmic protein. (377 aa)
	IL6ST	Interleukin-6 receptor subunit beta. (918 aa)
	TNFSF4	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (181 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (391 aa)
	IGF2	Insulin-like growth factor II. (192 aa)
	FOXP3	Forkhead box protein P3. (430 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
	ENSFDAP00000014392	annotation not available (76 aa)
	LOC104849006	HLA class II histocompatibility antigen, DM beta chain. (263 aa)
	ZAP70	Tyrosine-protein kinase. (576 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	CD1D	Antigen-presenting glycoprotein CD1d. (326 aa)
	Stat5b	Signal transducer and activator of transcription 5B. (736 aa)
	SYK	Tyrosine-protein kinase. (629 aa)
	Bmi1	Polycomb complex protein BMI-1. (326 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (380 aa)
	SHH	Sonic hedgehog protein. (244 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (501 aa)
	CARMIL2	Leucine-rich repeat-containing protein 16C. (1327 aa)
	SPTA1	Spectrin alpha chain, erythrocyte. (2398 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	KITLG	Kit ligand. (272 aa)
	ADK	Adenosine kinase. (336 aa)
	LOC104868980	Lymphotactin. (112 aa)
	CD276	CD276 molecule. (317 aa)
	Nck1	Cytoplasmic protein. (377 aa)
	Vcam1	Vascular cell adhesion protein 1. (742 aa)
	CCL19	C-C motif chemokine. (104 aa)
	IL23R	Interleukin-12 receptor subunit beta-2. (633 aa)
	Slamf1	Signaling lymphocytic activation molecule. (323 aa)
	Rps3	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	SELENOK	Selenoprotein K. (93 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	LOC104854203	CD59 glycoprotein. (129 aa)
	TFRC	Transferrin receptor protein 1. (765 aa)
	CARD11	Caspase recruitment domain-containing protein 11. (1154 aa)
	ANXA1	Annexin A1. (346 aa)
	IL23A	Interleukin-23 subunit alpha. (189 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (181 aa)
	Dhps	Deoxyhypusine synthase. (369 aa)
	LEP	Leptin. (167 aa)
	LOC104874398	Cytoplasmic protein NCK1-like. (348 aa)
	TYK2	Tyrosine-protein kinase. (981 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
	CD6	T-cell differentiation antigen CD6. (607 aa)
	LOC104868984	Lymphotactin. (113 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain. (169 aa)
	EFNB1	Ephrin-B1; Belongs to the ephrin family. (345 aa)
	IL21	Interleukin 21. (155 aa)
	BLM	Bloom syndrome protein. (1348 aa)
	ENSFDAP00000002799	annotation not available (144 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
	Il18	Interleukin-18. (293 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (255 aa)
	CD274	Programmed cell death 1 ligand 1. (322 aa)
	HES1	Transcription factor HES-1. (278 aa)
	H920_15994	Tyrosine-protein kinase. (1024 aa)
	SLC7A1	High affinity cationic amino acid transporter 1. (672 aa)
	CD86	T-lymphocyte activation antigen CD86. (317 aa)
	IGF1	Insulin-like growth factor I. (158 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	IGFBP2	Insulin-like growth factor-binding protein 2. (217 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	FOXP3	ENSFDAP00000009779	ENSFDAP00000015807	Adenosine kinase.	Forkhead box protein P3.	0.456
ADK	GPAM	ENSFDAP00000009779	ENSFDAP00000010490	Adenosine kinase.	Glycerol-3-phosphate acyltransferase 1, mitochondrial.	0.563
ADK	IL15	ENSFDAP00000009779	ENSFDAP00000005822	Adenosine kinase.	Interleukin; Belongs to the IL-15/IL-21 family.	0.521
ADK	IL23A	ENSFDAP00000009779	ENSFDAP00000006030	Adenosine kinase.	Interleukin-23 subunit alpha.	0.653
ADK	IL23R	ENSFDAP00000009779	ENSFDAP00000008081	Adenosine kinase.	Interleukin-12 receptor subunit beta-2.	0.741
ADK	IL6ST	ENSFDAP00000009779	ENSFDAP00000016427	Adenosine kinase.	Interleukin-6 receptor subunit beta.	0.726
AGER	H920_15994	ENSFDAP00000021332	ENSFDAP00000001901	Advanced glycosylation end product-specific receptor.	Tyrosine-protein kinase.	0.767
AGER	IL15	ENSFDAP00000021332	ENSFDAP00000005822	Advanced glycosylation end product-specific receptor.	Interleukin; Belongs to the IL-15/IL-21 family.	0.424
AGER	Il1b	ENSFDAP00000021332	ENSFDAP00000018361	Advanced glycosylation end product-specific receptor.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.470
AGER	JAK2	ENSFDAP00000021332	ENSFDAP00000018107	Advanced glycosylation end product-specific receptor.	Tyrosine-protein kinase.	0.908
AGER	TYK2	ENSFDAP00000021332	ENSFDAP00000004418	Advanced glycosylation end product-specific receptor.	Tyrosine-protein kinase.	0.667
ANXA1	CD81	ENSFDAP00000006349	ENSFDAP00000016621	Annexin A1.	Tetraspanin.	0.548
ANXA1	Il1b	ENSFDAP00000006349	ENSFDAP00000018361	Annexin A1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.407
CARD11	CD28	ENSFDAP00000006402	ENSFDAP00000002301	Caspase recruitment domain-containing protein 11.	T-cell-specific surface glycoprotein CD28.	0.548
CARD11	FADD	ENSFDAP00000006402	ENSFDAP00000000029	Caspase recruitment domain-containing protein 11.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.410
CARD11	NCKAP1L	ENSFDAP00000006402	ENSFDAP00000021737	Caspase recruitment domain-containing protein 11.	Nck-associated protein 1-like.	0.402
CARD11	PRKCQ	ENSFDAP00000006402	ENSFDAP00000020467	Caspase recruitment domain-containing protein 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.977
CARD11	RIPK2	ENSFDAP00000006402	ENSFDAP00000019312	Caspase recruitment domain-containing protein 11.	Receptor-interacting serine/threonine-protein kinase 2.	0.672
CARD11	SYK	ENSFDAP00000006402	ENSFDAP00000012634	Caspase recruitment domain-containing protein 11.	Tyrosine-protein kinase.	0.702
CARD11	TRAF6	ENSFDAP00000006402	ENSFDAP00000015339	Caspase recruitment domain-containing protein 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.861